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New drug shows promise in fighting Tuberculosis (TB)

Scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have determined how a promising drug candidate attacks the bacterium that causes tuberculosis (TB). Published online this week in Proceedings of the National Academy of Sciences, the finding may help scientists optimize the drug candidate, PA-824, which targets Mycobacterium tuberculosis (M. tb).

28 Dec 2005

New drug shows promise in fighting Tuberculosis (TB)

28 Dec 2005

Blue-green algae shows promise as a natural weapon against Alzheimer's

A compound isolated from a cyanobacterium, a type of blue-green algae known as Nostoc, shows promise of becoming a natural drug candidate for fighting Alzheimer's and other neurodegenerative diseases, according to an in vitro study by researchers in Switzerland.

28 Dec 2005

Targeted cancer therapies: Another step forward

While it is clear that the treatment of cancer has already begun to undergo a paradigm shift with the inclusion of innovative targeted therapies into current regimens, it would be wrong to assume these products will entirely replace traditional chemotherapy as the standard treatment for cancer sufferers.

22 Dec 2005

Targeted cancer therapies: Another step forward

22 Dec 2005

Insight into how marajuana induced munchies works

Marijuana--or more specifically its active ingredient, tetrahydrocannabinol--has a well-documented tendency to stimulate hunger. And while scientists have traced this property to cannabinoid receptors in the brain, they have had little understanding of the neural circuitry underlying this effect.

22 Dec 2005

New techniques are able to detect and monitor Alzheimer's disease

The search for new measures, or "biomarkers," to detect Alzheimer's disease (AD) before signs of memory loss appear has advanced an important step in a study by researchers at Washington University in St. Louis, MO, and the University of Pittsburgh.

22 Dec 2005

Synthetic compound could arrest development of Alzheimer's

Spanish chemists have developed a promising set of synthetic compounds that one day could help slow or perhaps halt the progression of Alzheimer's disease and other neurological disorders.

21 Dec 2005

University at Buffalo researches rules for targeting RNA

Once described as DNA's less-famous chemical cousin, RNA, or ribonucleic acid, recently has moved to center stage.

15 Dec 2005

New treatment for chronic Immune Thrombocytopenic Purpura

Data from a Phase II study of eltrombopag, an oral investigational drug that increases the production of platelets, demonstrate that the compound was effective in increasing platelet counts in patients with chronic Immune Thrombocytopenic Purpura (ITP), a disorder characterized by episodes of frequent spontaneous bruising, mucosal bleeding, and in severe cases intracranial hemorrhage, and acute episodes of severe bleeding.

12 Dec 2005

Finding how water channels - aquaporins - open and close may lead to new drugs

Living organisms are dependent on being able to adjust the water content in their cells. This is achieved by regulating the flow of water through the cell membrane.

12 Dec 2005

Study suggests a way to eliminate glioblastoma

Scientists have devised a strategy to treat tumors by selectively targeting and killing the malignant cells. A new preclinical study, published in the open access journal PLoS Medicine, has applied the approach to combat glioblastoma multiforme (GBM).

7 Dec 2005

Cancer, genes and broccoli

People who gain less protection from cancer by eating broccoli may be able to compensate for the difference in their genetic make-up by eating 'super broccoli', a variety with higher levels of the active plant chemical sulforaphane, or by eating larger portions.

7 Dec 2005

New type of sulfite reductase

Biswarup Mukhopadhyay and Eric Johnson from the Virginia Bioinformatics Institute at Virginia Tech have discovered a novel enzyme that represents an ancient detoxification system and provides a clue to the development of early metabolism on earth.

7 Dec 2005

Reimbursement structures across Europe create challenges for orthopaedic braces and supports manufacturers

A rapidly ageing population, the increasing trend toward non-invasive treatments and better disease management strategies are driving the demand for orthopaedic braces and supports in Europe.

7 Dec 2005

Cerebrospinal fluid analysis combined with brain scan predicts Alzheimer's

A combination of brain scanning with a new imaging agent and cerebrospinal fluid (CSF) analysis has left neuroscientists encouraged that they may finally be moving toward techniques for diagnosing Alzheimer's disease before its clinical symptoms become apparent.

5 Dec 2005

Alagebrium may prevent arterial aging in patients with systolic hypertension

A compound called alagebrium, which is very similar to another used in anti-wrinkle creams, may be useful in reducing the deleterious effects of arterial aging in the majority of elderly Americans with systolic hypertension, a new study from researchers at Johns Hopkins shows.

5 Dec 2005

Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease

Scientists at the Johns Hopkins Kimmel Cancer Center have found that a gene pathway linked to a deadly form of leukemia may provide a new way to treat autoimmune diseases, including multiple sclerosis.

2 Dec 2005

Chronic stress induces rapid occlusion of angioplasty

Chronic stress can induce rapid blocking of arteries after a balloon angioplasty procedure, according to research performed in animal studies at Georgetown University Medical Center. Blocked coronary arteries after angioplasty affect 41 percent of patients who undergo the procedure and can lead to death.

28 Nov 2005

Exploiting biology's own chemical toolbox...

Exploiting biology's own chemical toolbox, researchers have developed a new technique that will allow them to modify specific sequences within a DNA molecule. The approach will not only help reveal the impact of biochemical alterations to DNA, but could have far-reaching implications for DNA-based medical diagnosis and nanobiotechnology.

28 Nov 2005