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Scientists produce high-resolution 3D image of sarcomere using electron cryo-tomography

Scientists have produced the first high-resolution 3D image of the sarcomere, the basic contractile unit of skeletal and heart muscle cells, by using electron cryo-tomography (cryo-ET).

25 Mar 2021

Potent nanobody binds SARS-CoV-2 spike in an extraordinary manner

In a new study, published recently on the bioRxiv preprint server, researchers isolated a nanobody that potently neutralizes SARS-CoV-2, including the B.1.351 variant, and cross-neutralizes SARS-CoV. They demonstrated the therapeutic potential of the nanobody in a human ACE2 (angiotensin-converting enzyme) transgenic mouse model.

24 Mar 2021

Researcher uses alternative approach to find genetic drivers of rare eye disease

An analysis of thousands of genomes from people with and without the rare eye disease known as MacTel has turned up more than a dozen gene variants that are likely causing the condition to develop and worsen for a significant share of patients.

23 Mar 2021

A new COVID-19 candidate vaccine induces robust humoral and cellular immune responses in mice

A Korea-based company EyeGene Inc. has recently developed a liposome-based mRNA candidate vaccine against COVID-19, which contains full-length spike protein of the European variant (D614G) of SARS-CoV-2 as a vaccine antigen.

23 Mar 2021

Could nanoparticle vaccines offer broad protection against sarbecoviruses?

To understand the ability of SARS-CoV-2 vaccine-elicited antibodies to neutralize and protect against emerging variants (that are pathogenic) and other sarbecoviruses, a large team of researchers studied immunity by receptor-binding domain nanoparticle vaccines. They showed that a clinical-stage multivalent SARS-CoV-2 receptor-binding domain nanoparticle vaccine (SARS-CoV-2 RBD-NP) protected mice from the SARS-CoV-2-induced disease.

22 Mar 2021

New antibiotic compound can effectively clear multi-drug resistant gonorrhea in animals

A new antibiotic compound clears infection of multi-drug resistant gonorrhea in mice in a single oral dose, according to a new study led by researchers at Penn State and Emory University.

19 Mar 2021

N-terminal domain antibodies play a key role in COVID immunity

Scientists are learning that a lesser-studied region on the pandemic coronavirus is recognized by COVID-19 infection-fighting antibodies. These antibodies were identified in blood samples from previously infected patients, and were found to potently prevent the virus from infecting cells.

19 Mar 2021

Study shows how coronavirus variants spread more quickly

The fast-spreading UK, South Africa, and Brazil coronavirus variants are raising both concerns and questions about whether COVID-19 vaccines will protect against them.

18 Mar 2021

UTSW researchers identify the structure of a key cell-surface protein

UT Southwestern researchers have identified the structure of a key member of a family of proteins called nicotinic acetylcholine receptors in three different shapes.

17 Mar 2021

Study investigates activity of enzymes immobilized on gold nanoparticles controlled by infrared laser irradiation

The activity of enzymes in industrial processes, laboratories, and living beings can be remotely controlled using light. This requires their immobilization on the surface of nanoparticles and irradiation with a laser. Near-infrared light can penetrate living tissue without damaging it.

17 Mar 2021

Study explores how SARS-CoV-2 mutations produce antibody resistance and enhanced transmissibility

An interesting new study deals with the effects of the natural mutations in the spike antigen of the SARS-CoV-2, the pathogen that is responsible for the ongoing coronavirus disease pandemic.

16 Mar 2021

Synthesis of photocatalytic and antibacterial materials for removing medicines from wastewater

The Theoretical and Computational Chemistry Laboratory (QTC) of the Jaume I University of Castellón (UJI), in collaboration with the Centre for the Development of Functional Materials (CDMF) of the Universidad Federal de São Carlos (UFSCar), has published an article entitled “Selective Synthesis of α-, β-, and γ-Ag2WO4 Polymorphs: Promising Platforms for Photocatalytic and Antibacterial Materials” in scientific journal Inorganic Chemistry, which showcases new photocatalytic and antibacterial materials to remove medicines from wastewater.

15 Mar 2021

Neutralizing nanobodies effective against SARS-CoV-2 variants

Nanobodies have different mechanisms to neutralize viruses, and some target epitopes not accessible to monoclonal antibodies, making them an alternative for developing therapies for COVID-19.

15 Mar 2021

Study targets main protease of SARS-CoV-2 involved in viral replication

The main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enzyme implicated in the transcription and replication of the coronavirus. New research led by S. Samar Hasnain from the University of Liverpool in the United Kingdom used the selenium-containing drug Ebselen to analyze the SARS-CoV-2 main protease (Mpro).

14 Mar 2021

Study maps crucial component of long-term immune response to SARS-CoV-2

Researchers in the United States have found that protective antibodies generated against the original strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)– the agent that causes coronavirus disease 2019 (COVID-19) – also protect against viral variants.

14 Mar 2021

New vaccination method aims at comprehensive protection against all known influenza mutations

One shot, protected forever: This would be a dream come true regarding influenza vaccinations. So far, vaccination against influenza did not provide a lasting protection.

13 Mar 2021

Researchers use EPR spectroscopy to learn more about "Parkinson protein"

The protein α-synuclein is one of the most abundant proteins in the human brain. It is often referred to as the "Parkinson protein", as deposition of this protein in brain cells is a hallmark of Parkinson's disease.

11 Mar 2021

SARS-CoV-2 spike S1 subunit induces hypercoagulability

The vascular complications of the condition include a range of various coagulopathies that cause bleeding and thrombocytopenia or a hypercoagulable state. A new preprint research paper posted to the medRxiv server describes the role of a fibrinogen-related protein in inducing these clinical features of COVID-19.

10 Mar 2021

Tiny antibodies naturally generated by llamas can be effective against COVID-19

As the fight against COVID-19 continues, scientists have turned to an unlikely source for a potentially effective treatment: tiny antibodies naturally generated by llamas.

10 Mar 2021

Research demonstrates multivalent nanobodies overcome SARS-CoV-2 variant mutations

In a recent bioRxiv* preprint paper, researchers isolated anti-RBD nanobodies from llamas and “nanomice” (they engineered to produce VHHs cloned from alpacas, dromedaries and camels).

10 Mar 2021

Electron News and Research

Scientists produce high-resolution 3D image of sarcomere using electron cryo-tomography

Potent nanobody binds SARS-CoV-2 spike in an extraordinary manner

Researcher uses alternative approach to find genetic drivers of rare eye disease

A new COVID-19 candidate vaccine induces robust humoral and cellular immune responses in mice

Could nanoparticle vaccines offer broad protection against sarbecoviruses?

New antibiotic compound can effectively clear multi-drug resistant gonorrhea in animals

N-terminal domain antibodies play a key role in COVID immunity

Study shows how coronavirus variants spread more quickly

UTSW researchers identify the structure of a key cell-surface protein

Study investigates activity of enzymes immobilized on gold nanoparticles controlled by infrared laser irradiation

Study explores how SARS-CoV-2 mutations produce antibody resistance and enhanced transmissibility

Synthesis of photocatalytic and antibacterial materials for removing medicines from wastewater

Neutralizing nanobodies effective against SARS-CoV-2 variants

Study targets main protease of SARS-CoV-2 involved in viral replication

Study maps crucial component of long-term immune response to SARS-CoV-2

New vaccination method aims at comprehensive protection against all known influenza mutations

Researchers use EPR spectroscopy to learn more about "Parkinson protein"

SARS-CoV-2 spike S1 subunit induces hypercoagulability

Tiny antibodies naturally generated by llamas can be effective against COVID-19

Research demonstrates multivalent nanobodies overcome SARS-CoV-2 variant mutations

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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