Omicron News and Research

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Primary vaccinations and boosters effective in reducing COVID-19 severity during Delta and Omicron predominance

In a new study, researchers analyzed COVID-19 vaccination and surveillance data to understand the effect of primary vaccinations, boosters, and prior SARS-CoV-2 infections on severe COVID-19 outcomes and subsequent infections.

29 Sep 2022

How a major COVID-19 outbreak occurred in a naïve and vaccinated population in Taiwan with a limited number of entry events

Researchers explored the SARS-CoV-2 genome using high-throughput genome sequencing to provide novel insights into how the novel SARS-CoV-2 Omicron BA.2.3.7 variant enters and spreads among the otherwise naïve Taiwanese population.

29 Sep 2022

Study examines the incidence of severe COVID-19 in fully vaccinated and boosted high-risk populations

In new research, scientists studied a cohort of patients at the U.S Veterans Health Administration facilities to determine the incidence of severe COVID-19 outcomes among individuals with primary and booster doses of any combination of BNT162b2, mRNA-1273, and Ad26.COV2.S vaccines.

29 Sep 2022

Study suggests B-cell responses to booster vaccines are impeded by recent SARS-CoV-2 infection

Researchers investigated whether the time of booster vaccination relative to SARS-CoV-2 infection is a crucial determinant of the elicited immune response; in particular, the antibody and B-cell responses.

29 Sep 2022

Exploring remdesivir resistance in COVID-19-infected transplant recipients

In a new study, researchers assessed the remdesivir resistance developed in coronavirus disease 2019 (COVID-19)-infected transplant recipients.

29 Sep 2022

Significant humoral immune evasion contributes to the emergence and rapid spread of Arg346-mutated BA.4 and BA.5 sublineages

=Researchers measured the neutralizing titers of plasma samples against the SARS-CoV-2 new variant of concern Omicron's sub-variants BA.4 and BA.5 with arginine (Arg)346 mutations.

29 Sep 2022

What is the role of N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 spike maturation?

A new study showed that SARS-CoV-2 Spike N-glycosylation patterns, intracellular lectins, and the associated molecular chaperones play crucial roles in the viral-host-cell invasion and function.

28 Sep 2022

mRNA boosters associated with decreased odds of hospitalization compared with the mRNA vaccine primary series alone

Researchers assessed the chances of COVID-19 hospitalization after three versus two mRNA vaccine doses.

28 Sep 2022

Researchers computationally design immunogens to elicit antibodies against different SARS-CoV-2 variants

A recent study designed immunogens to induce antibodies against SARS-CoV-2 variants.

28 Sep 2022

Wearable devices show promise in identifying early population changes in COVID-19 activity

Today, viral illnesses like COVID-19 are tracked using multiple different methods, including lab data, health care visits and wastewater surveillance.

28 Sep 2022

Wastewater epidemiology can guide local clinical decisions on circulating viruses

The findings of a new study posted to the medRxiv* preprint server depicted that wastewater-based epidemiology (WBE) can provide information on the circulating respiratory viruses in a community. As well as saving time and money, this method may assist in appropriate clinical decision-making, behavior modification, and public health interventions.

28 Sep 2022

Observing SARS-CoV-2 Omicron reinfections with different sub-variants

In a new study, researchers observed early recurrence of coronavirus disease 2019 (COVID-19).

27 Sep 2022

Natural product SSP derived from a Chinese herb may have broad antiviral activities against respiratory viral infections

A research team comprised of members of the School of Chinese Medicine, AIDS Institute, Department of Microbiology, School of Clinical Medicine and State Key Laboratory for Emerging Infectious Diseases, the LKS Faculty of Medicine, The University of Hong Kong (HKUMed) have discovered a natural product SSP derived from a Chinese herb Spatholobus Suberectus Dunnthat demonstrated broad antiviral activities against SARS-CoV-1, SARS-CoV-2, influenza, and HIV-1 as an entry blocker.

27 Sep 2022

Evolution of pathogens during vaccination programs

New research summarized the current understanding of pathogen evolution.

27 Sep 2022

How do clinical outcomes in patients infected with different Omicron subvariants differ?

Researchers compare the clinical outcomes, upper respiratory viral loads, and viral recovery of different SARS-CoV-2 Omicron subvariants on cell cultures.

27 Sep 2022

Differences in protection from previous infection or vaccination against infection with Omicron BA.4/5 or BA.2

Researchers investigated the differences in vaccination- and previous infection-induced immunities against the Omicron BA.2 and BA.4/5 subvariants of SARS-CoV-2.

27 Sep 2022

New scoring tool helps to 'transparently' prioritize which countries need Covid-19 vaccines the most

A new scoring tool that helps to 'transparently' prioritize which countries are in greatest need of Covid-19 vaccines, has been developed by a UCL-led team of researchers.

27 Sep 2022

The antibody response against SARS-CoV-2 in patients pre- and post-infusion with commercial intravenous immunoglobulin products

Researchers comparatively evaluated antibody responses against SARS-CoV-2 among immunodeficient individuals pre- and post-intravenous immunoglobulin product infusions.

27 Sep 2022

First data on Pfizer-BioNTech's Omicron BA.4/5 combination vaccine

In a recent study posted to the bioRxiv* preprint server, researchers from Germany and the United States analyzed the association between exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.4/BA.5 spike glycoprotein and pan-Omicron neutralization.

27 Sep 2022

First real-world study shows the effectiveness of mRNA COVID-19 vaccines during pregnancy

The first large, real-world study of the effectiveness of mRNA COVID-19 vaccines during pregnancy found these vaccines, especially two initial doses followed by a booster, are effective in protecting against serious disease in expectant mothers whether the shots are administered before or during pregnancy.

27 Sep 2022

Omicron News and Research

Primary vaccinations and boosters effective in reducing COVID-19 severity during Delta and Omicron predominance

How a major COVID-19 outbreak occurred in a naïve and vaccinated population in Taiwan with a limited number of entry events

Study examines the incidence of severe COVID-19 in fully vaccinated and boosted high-risk populations

Study suggests B-cell responses to booster vaccines are impeded by recent SARS-CoV-2 infection

Exploring remdesivir resistance in COVID-19-infected transplant recipients

Significant humoral immune evasion contributes to the emergence and rapid spread of Arg346-mutated BA.4 and BA.5 sublineages

What is the role of N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 spike maturation?

mRNA boosters associated with decreased odds of hospitalization compared with the mRNA vaccine primary series alone

Researchers computationally design immunogens to elicit antibodies against different SARS-CoV-2 variants

Wearable devices show promise in identifying early population changes in COVID-19 activity

Wastewater epidemiology can guide local clinical decisions on circulating viruses

Observing SARS-CoV-2 Omicron reinfections with different sub-variants

Natural product SSP derived from a Chinese herb may have broad antiviral activities against respiratory viral infections

Evolution of pathogens during vaccination programs

How do clinical outcomes in patients infected with different Omicron subvariants differ?

Differences in protection from previous infection or vaccination against infection with Omicron BA.4/5 or BA.2

New scoring tool helps to 'transparently' prioritize which countries need Covid-19 vaccines the most

The antibody response against SARS-CoV-2 in patients pre- and post-infusion with commercial intravenous immunoglobulin products

First data on Pfizer-BioNTech's Omicron BA.4/5 combination vaccine

First real-world study shows the effectiveness of mRNA COVID-19 vaccines during pregnancy

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