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Computer simulation for predicting effectiveness of combination therapies for colon tumors

Scientist at Charité - Universitätsmedizin Berlin have used a computer simulation for predicting the effectiveness of various combination therapies for colon tumors. The study has been published in the current issue of the professional journal Molecular Systems Biology*.

28 Jun 2013

Study: Children with Crohn's disease have enterovirus in their intestines

A new study reveals that all children with Crohn's disease that were examined had a commonly occurring virus - an enterovirus - in their intestines. This link has previously not been shown for this chronic inflammatory intestinal disorder. The findings are being published today in the latest issue of the international journal Clinical and Translational Gastroenterology.

28 Jun 2013

Stanford researchers take new step in deciphering of histone code

A chemical code scrawled on histones - the protein husks that coat DNA in every animal or plant cell - determines which genes in that cell are turned on and which are turned off.

28 Jun 2013

University of Sheffield researchers show how human skin constantly regrows

We constantly grow new skin and slough off the old. Until now, scientists have never agreed on exactly how this works, but new research from the University of Sheffield may provide the answer.

27 Jun 2013

Findings suggest BRAF-mutant colon tumor cells may be less sensitive to the effect of aspirin

In 2 large studies, the association between aspirin use and risk of colorectal cancer was affected by mutation of the gene BRAF, with regular aspirin use associated with a lower risk of BRAF-wild-type colorectal cancer but not with risk of BRAF-mutated cancer, findings that suggest that BRAF-mutant colon tumor cells may be less sensitive to the effect of aspirin, according to a study in the June 26 issue of JAMA.

26 Jun 2013

Lung cancer in women more frequently associated with EGFR mutation and ER expression

The incidence of lung cancer in women affects an estimated 516,000 women worldwide, of which 100,000 are in the United States and 70,000 in Europe. Until now, lung cancers occurring in women have been treated similarly to lung cancers in men. However, numerous studies have highlighted different characteristics of lung cancer in women.

26 Jun 2013

Scientist discovers key mutations that sparked hormonal revolution 500 million years ago

Evolution, it seems, sometimes jumps instead of crawls. A research team led by a University of Chicago scientist has discovered two key mutations that sparked a hormonal revolution 500 million years ago.

25 Jun 2013

UCSF scientists explore how Dact1 mutations contribute to psychiatric disorders

Gene mutations that cause cell signaling networks to go awry during embryonic development and lead to major birth defects may also cause subtle disruptions in the brain that contribute to psychiatric disorders such as schizophrenia, autism, and bipolar disorder, according to new research by UC San Francisco scientists.

25 Jun 2013

Investigators uncover connection between tumor metabolic process and progression of kidney cancer

Investigators in The Cancer Genome Atlas (TCGA) Research Network have uncovered a connection between how tumor cells use energy from metabolic processes and the aggressiveness of the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC).

24 Jun 2013

Bacterial DNA more likely to integrate in the genome of tumors than in normal healthy cells

Bacterial DNA may integrate into the human genome more readily in tumors than in normal human tissue, according to a new study from the University of Maryland School of Medicine's Institute for Genome Sciences. Researchers analyzed genomic sequencing data available from the Human Genome Project, the 1,000 Genomes Project and The Cancer Genome Atlas (TCGA). They considered the phenomenon of lateral gene transfer (LGT), the transmission of genetic material between organisms in the absence of sex.

21 Jun 2013

TSRI neuroscientists fill in significant gap in the understanding of how neurons mature

Neuroscientists at The Scripps Research Institute have filled in a significant gap in the scientific understanding of how neurons mature, pointing to a better understanding of some developmental brain disorders.

21 Jun 2013

Th17 lymphocyte: The master coordinator of cellular inflammation in vessel wall

Every year, more than 16,000 Americans die as a result of what's known as an "aortic dissection" - a catastrophic rupture of the aorta, the body's largest artery. Once thought to be a simple structural failure, aortic dissection is now understood to be caused by an inflammatory process that weakens the artery's walls.

21 Jun 2013

Alnylam presents new pre-clinical data of ALN-CC5 for treatment of complement-mediated diseases

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has presented new pre-clinical data with ALN-CC5, an RNAi therapeutic targeting complement component C5.

21 Jun 2013

MPIIB researchers show that Chlamydia infections can cause mutations in host DNA

Chlamydia trachomatis is a human pathogen that is the leading cause of bacterial sexually transmitted disease worldwide with more than 90 million new cases of genital infections occurring each year. About 70 percent of women infected with Chlamydia remain asymptomatic and these bacteria can establish chronic infections for months, or even years. Even when it causes no symptoms, Chlamydia can damage a woman's reproductive organs. In addition, standard antibacterial drugs are proving increasingly ineffective in complete eradication, as Chlamydia goes in to persistent mode, leading to asymptomatic chronic infection.

21 Jun 2013

Thirdhand smoke causes significant genetic damage in human cells

A study led by researchers from Lawrence Berkeley National Laboratory has found for the first time that thirdhand smoke-the noxious residue that clings to virtually all surfaces long after the secondhand smoke from a cigarette has cleared out-causes significant genetic damage in human cells.

21 Jun 2013

Research findings suggest potent new therapeutic target for certain types of cancer

Scientists have discovered the survival secret to a genetic mutation that stokes leukemia cells, solving an evolutionary riddle and paving the way to a highly targeted therapy for leukemia.

21 Jun 2013

TSRI scientists find dual inhibitor that attacks two enzymes associated with Parkinson's disease

Scientists from the Florida campus of The Scripps Research Institute have found a compound that could counter Parkinson's disease in two ways at once.

21 Jun 2013

Researchers receive NIH grant to study key proteins linked to cancer and diabetes

Researchers from the Polytechnic Institute of New York University and NYU have received a grant from the National Institutes of Health (NIH) to further a novel approach to understanding the genetic underpinnings of diseases including cancer and diabetes.

21 Jun 2013

Penn researchers find ALS disease progresses in a stepwise, sequential pattern

The motor neuron disease Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, progresses in a stepwise, sequential pattern which can be classified into four distinct stages, report pathologists with the Perelman School of Medicine at the University of Pennsylvania in the Annals of Neurology.

20 Jun 2013

Experts report lasting benefits of deep brain stimulation in patients with hereditary dystonia

In what is believed to be the largest follow-up record of patients with the most common form of hereditary dystonia - a movement disorder that can cause crippling muscle contractions - experts in deep brain stimulation report good success rates and lasting benefits.

20 Jun 2013

Mutation News and Research

Computer simulation for predicting effectiveness of combination therapies for colon tumors

Study: Children with Crohn's disease have enterovirus in their intestines

Stanford researchers take new step in deciphering of histone code

University of Sheffield researchers show how human skin constantly regrows

Findings suggest BRAF-mutant colon tumor cells may be less sensitive to the effect of aspirin

Lung cancer in women more frequently associated with EGFR mutation and ER expression

Scientist discovers key mutations that sparked hormonal revolution 500 million years ago

UCSF scientists explore how Dact1 mutations contribute to psychiatric disorders

Investigators uncover connection between tumor metabolic process and progression of kidney cancer

Bacterial DNA more likely to integrate in the genome of tumors than in normal healthy cells

TSRI neuroscientists fill in significant gap in the understanding of how neurons mature

Th17 lymphocyte: The master coordinator of cellular inflammation in vessel wall

Alnylam presents new pre-clinical data of ALN-CC5 for treatment of complement-mediated diseases

MPIIB researchers show that Chlamydia infections can cause mutations in host DNA

Thirdhand smoke causes significant genetic damage in human cells

Research findings suggest potent new therapeutic target for certain types of cancer

TSRI scientists find dual inhibitor that attacks two enzymes associated with Parkinson's disease

Researchers receive NIH grant to study key proteins linked to cancer and diabetes

Penn researchers find ALS disease progresses in a stepwise, sequential pattern

Experts report lasting benefits of deep brain stimulation in patients with hereditary dystonia

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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