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Deep-sea sponges harbor toxins that potentially can act as powerful anti-cancer drugs

Vibrantly colored creatures from the depths of the South Pacific Ocean harbor toxins that potentially can act as powerful anti-cancer drugs, according to research findings from University of Wisconsin-Madison biochemists and their Italian colleagues.

26 Sep 2005

First step towards effective drug-addiction therapies

A novel chemical compound that blocks memory-related drug cravings has the potential to be the basis of new therapies to aid drug-addiction recovery efforts, UC Irvine neurobiologists have found.

26 Sep 2005

Powerful orthopedic repair compound

Bone Solutions, Inc. of Dallas, TX, announced at a Dow Jones Lifescience Conference that it had successfully tested its magnesium-based orthopedic adhesive technology in multiple studies to prove full biocompatibility for injection into animals and humans, with powerful mechanical properties that gave its unusual strength and performance beyond current orthopedic industry products.

26 Sep 2005

Microchip system aims to reduce the number of animals used in the development of new drugs

Reducing the number of animals used in the development of new drugs is a priority for the pharmaceutical industry

26 Sep 2005

A new, less toxic way to treat malignant melanoma

A new, less toxic way to treat malignant melanoma (skin cancer) is being developed by medicinal chemists at Reading University. They have produced a range of prodrugs: compounds that offer the potential to be converted to toxic molecules only within the vicinity of tumours. These prodrugs aim to reduce the toxicity of treatment.

26 Sep 2005

Raf Kinase Inhibitor Protein plays a role in controlling the active movement of cells

University of Illinois at Chicago researchers report that a protein that regulates key signaling pathways in cells also plays a role in controlling the active movement or migration of cells. The finding may suggest new pharmaceutical therapies for treating a variety of diseases, including cancer.

26 Sep 2005

Discovery that protein CD38 interrupts an interaction between the AIDS virus and its point of entry into cells

Cornell University researchers have discovered the 3-D crystal structure of a protein, human CD38, which may lead to important discoveries about how cells release calcium - a mineral used in almost every cellular process.

19 Sep 2005

Compounds found in broccoli, cauliflower, and watercress block lung cancer progression

A family of compounds found in cruciferous vegetables, such as broccoli, cauliflower, and watercress, blocked lung cancer progression in both animal studies and in tests with human lung cancer cells, report researchers from Georgetown University Medical Center and the Institute for Cancer Prevention.

19 Sep 2005

Scientists have discovered a new and potent anti-cancer compound in beans

Scientists have discovered a new and potent anti-cancer compound in everyday food. The collaborative study led by UCL (University College London) shows that the compound - inositol pentakisphosphate - found in beans, nuts and cereals inhibits a key enzyme (phosphoinositide 3-kinase) involved in tumour growth.

19 Sep 2005

Screening test for cells that activate immune system

UT Southwestern Medical Center researchers are the first to create a large-scale, cell-based screening method that identifies which compounds activate immune-response cells that hold promise for future cancer-fighting vaccines.

12 Sep 2005

Nitric oxide could one day help women in their 30s and 40s remain fertile longer

Researchers have found that an important chemical compound, nitric oxide, appears to slow or reverse the aging of eggs in mouse ovaries. The finding suggests nitric oxide could one day help women in their 30s and 40s remain fertile longer and increase their chances of having healthy babies, the scientists say.

7 Sep 2005

Researchers develop screening test for cells that activate immune system

7 Sep 2005

Rev/Dex combo looks like a breakthrough treatment for multiple myeloma

Mayo Clinic Cancer Center investigators report that combination therapy with lenalidomide (Revlimid) and dexamethasone (combination is called Rev/Dex) looks like a breakthrough treatment for multiple myeloma. Results of a Phase II clinical trial were published online Aug. 23 in Blood.

1 Sep 2005

Compound called GRN163L blocks lung cancer

Researchers at UT Southwestern Medical Center have found a compound that shows promise as a way to block the spread, or metastasis, of lung cancer.

1 Sep 2005

Extra-virgin olive oil tastes good and is also an anti-inflammatory

After a tasting experience at a molecular gastronomy meeting in Sicily, biologist Gary Beauchamp of Pennsylvania University decided to analyse freshly pressed extra-virgin olive oil and found a chemical that acted like ibuprofen in the oil.

31 Aug 2005

Carbohydrate known as OGT2378 inhibits tumor growth

A non-toxic chemical compound that prevents cancer cells from producing a critical membrane component has been shown to suppress tumor growth and tumor size in mice without unwanted side effects, according to researchers at the Children’s National Medical Center in Washington, D.C.

30 Aug 2005

Molecular missing link between fasting and acute attacks of porphyria

A team of researchers has discovered a molecular missing link that helps explain why fasting brings on acute attacks of the genetic disease hepatic porphyria, according to a new report in the 26 August issue of the journal Cell.

29 Aug 2005

Compound might defeat African sleeping

One of the most devastating diseases in sub-Saharan Africa almost disappeared in the late 1950s.

26 Aug 2005

Scientists have developed a new dye that could offer noninvasive early diagnosis of Alzheimer's disease

MIT scientists have developed a new dye that could offer noninvasive early diagnosis of Alzheimer's disease, a discovery that could aid in monitoring the progression of the disease and in studying the efficacy of new treatments to stop it.

26 Aug 2005

Disease modifying activity of 2ME2 demonstrated in preclinical rheumatoid arthritis studies

EntreMed a clinical-stage pharmaceutical company developing therapeutics primarily for the treatment of cancer and inflammatory diseases, has announced the presentation of positive preclinical results for its lead compound, 2-methoxyestradiol (2ME2), in models of rheumatoid arthritis.

24 Aug 2005

Compound News and Research

Deep-sea sponges harbor toxins that potentially can act as powerful anti-cancer drugs

First step towards effective drug-addiction therapies

Powerful orthopedic repair compound

Microchip system aims to reduce the number of animals used in the development of new drugs

A new, less toxic way to treat malignant melanoma

Raf Kinase Inhibitor Protein plays a role in controlling the active movement of cells

Discovery that protein CD38 interrupts an interaction between the AIDS virus and its point of entry into cells

Compounds found in broccoli, cauliflower, and watercress block lung cancer progression

Scientists have discovered a new and potent anti-cancer compound in beans

Screening test for cells that activate immune system

Nitric oxide could one day help women in their 30s and 40s remain fertile longer

Researchers develop screening test for cells that activate immune system

Rev/Dex combo looks like a breakthrough treatment for multiple myeloma

Compound called GRN163L blocks lung cancer

Extra-virgin olive oil tastes good and is also an anti-inflammatory

Carbohydrate known as OGT2378 inhibits tumor growth

Molecular missing link between fasting and acute attacks of porphyria

Compound might defeat African sleeping

Scientists have developed a new dye that could offer noninvasive early diagnosis of Alzheimer's disease

Disease modifying activity of 2ME2 demonstrated in preclinical rheumatoid arthritis studies

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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