Enzyme News and Research

RSS

Researchers shown how free radicals contribute to fatty liver disease

An international team of scientists led by Monash University researchers has shown how free radicals contribute to type 2 diabetes, obesity and fatty liver disease.

23 Jun 2014

Study reveals that inflammasomes remain active even after cell death

Even after a cell dies, components of the immune system remain active and continue to fuel inflammatory reactions.

23 Jun 2014

Susceptibility gene for type 1 diabetes regulates self-destruction of cell's energy factory

A team led by researchers from the Perelman School of Medicine at the University of Pennsylvania found that a susceptibility gene for type 1 diabetes regulates self-destruction of the cell's energy factory. They report their findings this week in Cell.

20 Jun 2014

Clinical trial shows that selumetinib drug can delay progression of metastatic uveal melanoma

For the first time, a therapy has been found that can delay progression of metastatic uveal melanoma, a rare and deadly form of melanoma of the eye.

20 Jun 2014

Schizophrenia focus narrowed to dentate gyrus

The dentate gyrus is a likely site of pathology underlying schizophrenia, shows a study published in Molecular Psychiatry.

19 Jun 2014

Researchers discover crucial process that regulates development of blood vessels

Biologists at The Scripps Research Institute (TSRI) have discovered a crucial process that regulates the development of blood vessels.

19 Jun 2014

Debiopharm launches Phase 1 study of anti-infective agent Debio 1450

Debiopharm Group, a Swiss-based global biopharmaceutical company developing prescription drugs that target unmet medical needs as well as companion diagnostics, today announced the launch of a Phase 1 dose-escalation study of Debio 1450 (previously known as AFN-1720), a highly potent anti-infective agent that is selectively active against a large number of Staphylococcus species, including all known resistant strains such as methicillin-resistant S. aureus (MRSA) and vancomycin-intermediate S. aureus (VISA).

19 Jun 2014

Genetic variants linked to race that explains risk of death among patients taking Plavix after heart attack

Researchers have identified the first genetic variations linked to race that begin to explain a higher risk of death among some African American and Caucasian patients taking the anti-clotting drug clopidogrel (Plavix) after a heart attack.

18 Jun 2014

New approach promises better drugs for diabetes and osteoporosis

By swapping replacement parts into the backbone of a synthetic hormone, UW-Madison graduate student Ross Cheloha and his mentor, Sam Gellman, along with collaborators at Harvard Medical School, have built a version of a parathyroid hormone that resists degradation in laboratory mice.

18 Jun 2014

3SBio signs exclusive license agreement with Selecta Biosciences for pegsiticase

3SBio Inc., a leading China-based biotechnology company focused on researching, developing, manufacturing and marketing biopharmaceutical products, today announced it has entered into an exclusive license with Selecta Biosciences for pegsiticase (Uricase PEG-20), a pegylated recombinant uricase from candida utilis.

18 Jun 2014

FDA accepts Symplmed's Prestalia NDA for hypertension treatment

Symplmed announced today that the U.S. Food and Drug Administration has accepted for review its New Drug Application (NDA) for investigational drug Prestalia, the first single-pill, fixed-dose combination (FDC) of perindopril arginine and amlodipine besylate for the treatment of hypertension in the U.S. Symplmed filed the application under section 505(b)(2) consistent with FDA's guidance.

18 Jun 2014

A new approach to treating whipworm infections

Researchers have deduced essential biological and genetic information from the genome sequence of the whipworm, an intestinal parasitic worm that infects hundreds of millions of people in developing countries.

18 Jun 2014

Scottsdale Healthcare, TGen initiate AG-120 clinical trial in patients with solid tumors

The Virginia G. Piper Cancer Center at Scottsdale Healthcare and the Translational Genomics Research Institute are studying the safety and effectiveness of a new drug, AG-120, for treatment of patients with solid tumors, especially those with brain tumors and gallbladder bile duct cancer.

18 Jun 2014

Delphi Genetics announces new license agreement for use of StabyExpress technology in food industry

Delphi Genetics SA has announced today a new license agreement for the use of the StabyExpress® technology in the food industry. The technology will be used for the production of enzymes for food processing.

17 Jun 2014

Discovery may lead to new treatments for common autoimmune diseases

Researchers at the University of Georgia report in the Journal of Biological Chemistry that an enzyme known as Tumor Progression Locus 2, or Tpl2, plays a key role in directing and regulating several important components of the body's immune system.

17 Jun 2014

Researchers uncover key biological interaction that occurs during fertilization

Before it can fertilize an egg, a sperm has to bind to and bore through an outer egg layer known as the zona pellucida. Despite decades of research, some of the biological mechanisms behind this process remain unclear. A study in The Journal of Cell Biology now identifies the protein in the zona pellucida that sperm latch onto.

17 Jun 2014

Researchers show how to monitor glucose in diabetes using saliva instead of blood

Treating Diabetes - a major scourge of humanity bothering millions of people - requires a constant monitoring of the human blood for glucose concentrations.

16 Jun 2014

Specific enzyme helps protect good commensal bacteria from harmful effects of antibiotics

Researchers from Case Western Reserve University in Cleveland have discovered that populating the gastrointestinal (GI) tracts of mice with Bacteroides species producing a specific enzyme helps protect the good commensal bacteria from the harmful effects of antibiotics.

13 Jun 2014

New class of tumor-targeting agents can seek out dozens of solid tumors

Scientists at the University of Wisconsin Carbone Cancer Center (UWCCC) report that a new class of tumor-targeting agents can seek out and find dozens of solid tumors, even illuminating brain cancer stem cells that resist current treatments.

13 Jun 2014

Investigators isolate protein that is responsible for fungus' ability to cross blood-brain barrier

In a remarkable series of experiments on a fungus that causes cryptococcal meningitis, a deadly infection of the membranes that cover the spinal cord and brain, investigators at UC Davis have isolated a protein that appears to be responsible for the fungus' ability to cross from the bloodstream into the brain.

13 Jun 2014

Enzyme News and Research

Researchers shown how free radicals contribute to fatty liver disease

Study reveals that inflammasomes remain active even after cell death

Susceptibility gene for type 1 diabetes regulates self-destruction of cell's energy factory

Clinical trial shows that selumetinib drug can delay progression of metastatic uveal melanoma

Schizophrenia focus narrowed to dentate gyrus

Researchers discover crucial process that regulates development of blood vessels

Debiopharm launches Phase 1 study of anti-infective agent Debio 1450

Genetic variants linked to race that explains risk of death among patients taking Plavix after heart attack

New approach promises better drugs for diabetes and osteoporosis

3SBio signs exclusive license agreement with Selecta Biosciences for pegsiticase

FDA accepts Symplmed's Prestalia NDA for hypertension treatment

A new approach to treating whipworm infections

Scottsdale Healthcare, TGen initiate AG-120 clinical trial in patients with solid tumors

Delphi Genetics announces new license agreement for use of StabyExpress technology in food industry

Discovery may lead to new treatments for common autoimmune diseases

Researchers uncover key biological interaction that occurs during fertilization

Researchers show how to monitor glucose in diabetes using saliva instead of blood

Specific enzyme helps protect good commensal bacteria from harmful effects of antibiotics

New class of tumor-targeting agents can seek out dozens of solid tumors

Investigators isolate protein that is responsible for fungus' ability to cross blood-brain barrier

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo