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Researchers investigate the roles of STAT3α and STAT3β isoforms in aggressive breast cancer

A new research paper was published in Oncotarget's Volume 14 on April 24, 2023, entitled, "Differential silencing of STAT3 isoforms leads to changes in STAT3 activation."

26 Apr 2023

Possible risk factors for brain aneurysm development in adults living with HIV

With advances in antiretroviral therapy (ART), outcomes for adults living with human immunodeficiency virus (ALWH) have largely improved, drastically decreasing the risk of death from opportunistic infections.

26 Apr 2023

Spatial organization of immune cells predicts outcomes for patients with clear cell renal cell carcinoma

Outcomes for patients with clear cell renal cell carcinoma have improved over the past decade due to the approval of immunotherapies, yet still there is a subset of patients who do not respond to this type of therapy.

26 Apr 2023

Understanding how biological sex and immune system contribute to shaping the developing brain

Researchers have established that biological sex plays a role in determining an individual's risk of brain disorders.

26 Apr 2023

Research uncovers antibodies that are still effective against new variants of SARS-CoV-2

An anonymous San Diego resident has become a fascinating example of how the human immune system fights SARS-CoV-2.

26 Apr 2023

Researchers unravel processes that direct the development of astrocyte structure

Researchers at Baylor College of Medicine have unraveled the processes that give astrocytes, the most abundant glial cell in the brain, their special bushy shape, which is fundamental for brain function.

26 Apr 2023

Study sheds light on the mechanisms behind circadian rhythms

New research from a multidisciplinary team helps to illuminate the mechanisms behind circadian rhythms, offering new hope for dealing with jet lag, insomnia and other sleep disorders.

26 Apr 2023

Researchers take key step toward developing a gene therapy for Usher syndrome type 1F

Usher Syndrome type 1F is a rare but severe genetic disease that causes deafness, lack of balance, and progressive blindness.

26 Apr 2023

Study reveals ERK signaling as a crucial molecular switch between scarring and regeneration

Why do some animals regenerate lost tissues after injury while others don't? Researchers from the lab of Kerstin Bartscherer (Osnabrück University and formerly Hubrecht Institute) and Ashley Seifert (University of Kentucky) studied spiny mice, which have a remarkable regenerative capacity, to answer this question.

26 Apr 2023

Researchers identify regions of the viral envelope of simian foamy viruses targeted by neutralizing antibodies

A recent study characterized epitopes recognized by neutralizing antibodies from individuals infected with simian foamy virus.

26 Apr 2023

Discovery of Helicobacter's Achilles heel offers great potential for the development of new drugs

LMU researchers have discovered a weakness in the bacterium Helicobacter pylori, which could be exploited to develop new drugs.

26 Apr 2023

Shedding light on diabetes: Vitamin D's crucial role in insulin regulation and disease prevention

Research discusses the role of vitamin D in both type 1 and type 2 diabetes pathogenesis. It summarizes the molecular mechanisms of vitamin D in insulin secretion, insulin sensitivity, and immunity, as well as the observational and interventional human studies investigating the use of vitamin D as a treatment for diabetes.

25 Apr 2023

Neutrophils found to play a key role in fibromyalgia pain

Targeting neutrophil activity and interactions with sensory neurons may be a potential approach for treating fibromyalgia pain.

25 Apr 2023

Researchers discover a receptor and protein associated with Lou Gehrig's disease

Researchers at Nagoya University in Japan have discovered a receptor, sigma-1 receptor, and a protein, ATAD3A, that are associated with Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease.

25 Apr 2023

ASTRO/ESTRO's clinical guideline offers recommendations on the use of local therapy for oligometastatic NSCLC

A new clinical guideline from the American Society for Radiation Oncology and European Society for Radiotherapy & Oncology provides guidance on the use of definitive local therapy - including radiation and surgery - to treat patients with oligometastatic non-small cell lung cancer (NSCLC).

25 Apr 2023

Checkpoint inhibitors may not be effective lymphoma treatment when CAR T fails

For 30% to 40% of lymphoma patients who receive CAR T therapy, the treatment is a godsend.

25 Apr 2023

Previously unknown mechanisms may lead to new approaches to fight viral infections

Viruses like influenza A and Ebola invade human cells in a number of steps. In an interdisciplinary approach, research teams from Heidelberg University and Heidelberg University Hospital investigated the final stages of viral penetration using electron tomography and computer simulations.

25 Apr 2023

Researchers uncover the molecular basis for making long-term memories

Helping your mother make pancakes when you were three…riding your bike without training wheels…your first romantic kiss: How do we retain vivid memories of long-ago events? As described in a paper published online on April 25 in Neuron, researchers at Albert Einstein College of Medicine have found the explanation.

25 Apr 2023

Highly activatable Raman probes detect multiple enzyme activities in heterogeneous biological tissues

Raman imaging offers a greater potential for detecting multiple enzyme activities than fluorescence imaging, demonstrate Tokyo Tech researchers by developing 9CN-rhodol-based activatable Raman probes using a novel mechanism for Raman signal activation.

25 Apr 2023

Columbia University establishes the SNF Center for Precision Psychiatry & Mental Health with $75 million grant

Columbia University today announced the establishment of the Stavros Niarchos Foundation (SNF) Center for Precision Psychiatry & Mental Health at Columbia University.

25 Apr 2023

B Cell News and Research

Researchers investigate the roles of STAT3α and STAT3β isoforms in aggressive breast cancer

Possible risk factors for brain aneurysm development in adults living with HIV

Spatial organization of immune cells predicts outcomes for patients with clear cell renal cell carcinoma

Understanding how biological sex and immune system contribute to shaping the developing brain

Research uncovers antibodies that are still effective against new variants of SARS-CoV-2

Researchers unravel processes that direct the development of astrocyte structure

Study sheds light on the mechanisms behind circadian rhythms

Researchers take key step toward developing a gene therapy for Usher syndrome type 1F

Study reveals ERK signaling as a crucial molecular switch between scarring and regeneration

Researchers identify regions of the viral envelope of simian foamy viruses targeted by neutralizing antibodies

Discovery of Helicobacter's Achilles heel offers great potential for the development of new drugs

Shedding light on diabetes: Vitamin D's crucial role in insulin regulation and disease prevention

Neutrophils found to play a key role in fibromyalgia pain

Researchers discover a receptor and protein associated with Lou Gehrig's disease

ASTRO/ESTRO's clinical guideline offers recommendations on the use of local therapy for oligometastatic NSCLC

Checkpoint inhibitors may not be effective lymphoma treatment when CAR T fails

Previously unknown mechanisms may lead to new approaches to fight viral infections

Researchers uncover the molecular basis for making long-term memories

Highly activatable Raman probes detect multiple enzyme activities in heterogeneous biological tissues

Columbia University establishes the SNF Center for Precision Psychiatry & Mental Health with $75 million grant

Using single B cell screening to boost antibody discovery eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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