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Genetic switch that turns off an oxygen-poor cell's combustion engine - finding has potential to limit toxic molecules

Johns Hopkins researchers have discovered a previously unrecognized role played by the gene HIF-1 as it helps cell survive when a lack of oxygen decreases production of an energy-rich molecule called ATP and increases production of toxic molecules.

9 Mar 2006

Metabolic switch required for cellular adaptation to hypoxia

Two new studies in the March Cell Metabolism reveal a survival mechanism by which cells adapt to oxygen starvation by ratcheting down their demand.

9 Mar 2006

Pregnancy diet has lifelong effects for baby

University of Nottingham researchers are targeting Europe's biggest killer diseases - by focusing on the diet of unborn babies.

8 Mar 2006

MannKind initiates two phase 3 studies of inhaled Technosphere insulin

MannKind Corporation has announced that it has initiated patient enrollment in two pivotal 12-month Phase 3 clinical trials of Technosphere Insulin (TI) in patients with Type 1 and Type 2 Diabetes.

7 Mar 2006

Genes play a key role in stress response

Both nature and nurture - genetic makeup and the environment experienced through life - combine to influence health and well-being, Duke University Medical Center researchers and their colleagues have determined in four new studies.

7 Mar 2006

Validation of cardiovascular risk scores in a liver transplant population

Two methods of assessing a patient's risk of cardiovascular events - SCORE and PROCAM - proved more valuable for liver transplant recipients than an alternative method, according to a new study.

7 Mar 2006

Compound found in marijuana may defend against diabetic retinopathy

A compound found in marijuana won't make you high but it may help keep your eyes healthy if you're a diabetic, researchers say.

1 Mar 2006

PET and MR imaging reveals white matter degeneration in Huntington's

Using both brain function (PET) and anatomical structure (MR) imaging studies, Italian researchers - within the context of an Italian-British collaboration - discovered that degenerative and dysfunctional events occur in individuals many years before the onset of Huntington's disease - particularly in the brain's white matter - an area not previously considered primarily involved with the disease.

24 Feb 2006

Pig cells reverse diabetes in monkeys

A team of researchers in the U.S. have successfully reversed diabetes in monkeys using transplanted islet cells from pigs.

21 Feb 2006

Pig islets successfully reversed diabetes in monkeys

Researchers at the University of Minnesota's Diabetes Institute for Immunology and Transplantation have successfully reversed diabetes in monkeys using transplanted islet cells from pigs.

19 Feb 2006

Rimonabant produces sustained weight loss long term

Use of the weight-loss medication rimonabant produced modest yet sustained weight loss after 2 years, and improved HDL cholesterol and triglyceride levels, according to a study in the February 15 issue of JAMA: The Journal of the American Medical Association.

17 Feb 2006

Brain scans may detect neurological decline in normal people

Brain scans may detect neurological changes in people who exhibit no outward signs of cognitive decline but who later develop dementia or mental impairment, according to the results of a new study led by researchers at the University of California, Berkeley.

16 Feb 2006

Link between glucose levels and death in patients with cardiovascular disease

Men with cardiovascular disease may be at considerably increased risk for death even when their blood sugar level remains in the "normal" range, suggests a new study by a team of scientists at UCLA and Cedars-Sinai Medical Center in Los Angeles.

16 Feb 2006

Diabetics warned against using antibiotic drug Tequin

The Food and Drug Administration in the U.S. have issued strong warnings concerning the use of the antibiotic drug Tequin.

16 Feb 2006

French may be headed for similar obesity and heart problems as U.S.

Just 2 pounds of weight gain can greatly increase a person's risk for the metabolic syndrome, a dangerous condition that can lead to type 2 diabetes and coronary heart disease, finds a Kaiser Permanente study.

7 Feb 2006

Chromium helps muscles become more efficient

Researchers found that daily use of chromium picolinate enhanced muscle sensitivity to insulin in obese, insulin-resistant rats

7 Feb 2006

Amputation among patients with diabetes mellitus - increased risk of neuropathy and diabetic ulcers in taller patients

Patients with diabetes mellitus are at risk of leg ulcers. These eventually become infected, respond poorly to treatment and often require amputation of the foot or part of the leg.

7 Feb 2006

PET imaging has the potential to improve cancer care management

A limitation of current cancer care is the difficulty of quickly assessing how well a therapy is working. However, expanding the use of existing positron emission tomography (PET) technology can provide early and accurate assessment of a tumor's response to a particular therapy allowing physicians to better tailor a patient's treatment

7 Feb 2006

Diet rich in whole-grain foods may lower heart disease risk in elderly people

With the recent revision of the Food Guide Pyramid, the Dietary Guidelines for Americans have for the first time provided the public with a quantitative recommendation for whole-grain intake.

7 Feb 2006

Imaging technology detects subtle brain changes in Type 1 diabetics

Although people with diabetes are twice as likely as the general population to develop depression, the cause of this increased risk is not well understood.

7 Feb 2006