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Researchers make gains in understanding antibiotic resistance

Howard Hughes Medical Institute researchers chiseling away at the problem of antibiotic resistance now have a detailed explanation of how the drugs' main cellular target in bacteria evolves to become resistant to some of these medications.

22 Apr 2005

Discovery may lead to new drugs to prevent sexually transmitted HIV infection

Scientists have long suspected that HIV hijacks immune cells called dendritic cells to infiltrate the immune system. Now UCLA AIDS Institute researchers have shown that blocking HIV's access to a naturally occurring molecule on dendritic cells may cut their ability to smuggle the virus into other immune cells.

21 Apr 2005

Why people get drowsy and fall asleep, and how caffeine blocks that process

When cells in a certain part of the brain become overworked, a compound in the brain kicks in, telling them to shut down. This causes people to become drowsy and fall asleep. Alter that natural process by adding coffee or tea, and the brain compound – called adenosine – is blocked, and people stay awake.

20 Apr 2005

New era drug gives hope to Gleevec resistant leukaemia sufferers

Gleevec, a drug regarded by many as having "wonder drug" capabilities in the treatment of chronic myelogenous leukaemia (CML) and other cancers, has been revealed as having shortcomings in that some patients have undergone a relapse after building a resistance to the drug. For others with the advanced stage of the disease, the drug has failed to produce durable remissions.

19 Apr 2005

Researchers find promising cancer-fighting power of synthetic cell-signaling molecule

Novel anti-cancer compounds called Enigmols suppress the growth of human cell lines representing cancers of the prostate, breast, colon, ovary, pancreas, brain and blood, and reduce tumors in three animal studies, new research shows.

19 Apr 2005

Compound derived from cottonseed oil could help improve the effectiveness of chemotherapy at treating head and neck cancer

The findings, which will be presented Tuesday, April 19, at the American Association for Cancer Research annual meeting, could lead to a treatment that provides an effective option to surgically removing the cancer, helping patients preserve vital organs involved in speech and swallowing.

19 Apr 2005

Researchers and drug giant team up to find cure for CJD

The Medical Research Council's Prion Unit, based at University College London, a leading British research group, is joining forces with drugs giant GlaxoSmithKline (GSK) to develop a cure for the disease Creutzfeldt-Jakob Disease (CJD).

12 Apr 2005

Significant progress in pSivida BioSilicon drug delivery evaluation

Global nanotechnology company pSivida Limited has announced that its evaluation of selected compounds from an undisclosed top five global pharmaceutical company has progressed successfully.

11 Apr 2005

Pfizer withdraws Bextra from market

Despite an expert panel stating last month that the three COX-2 drugs Vioxx, Bextra and Celebrex were safe enough to be marketed, the U.S. Food and Drug Administration (FDA) has this week told drug manufacturer Pfizer to remove the drug Bextra from the market and a statement by Pfizer confirms that the European Union regulators have done the same.

7 Apr 2005

Potential therapeutic target for treating Huntington's disease

Researchers studying yeast cells have identified a metabolic enzyme as a potential therapeutic target for treating Huntington's disease, a fatal inherited neurodegenerative disorder for which there is currently no effective treatment. The group, whose results appear in the May issue of Nature Genetics, includes researchers from the University of Washington School of Medicine in Seattle and the University of Maryland School of Medicine in Baltimore.

6 Apr 2005

Study suggests that eating onions might help prevent bone loss and osteoporosis

Besides adding flavor to food, onions also may be good for your bones. Researchers at the University of Bern in Switzerland have identified a compound in the popular vegetable that appears to decrease bone loss in laboratory studies using rat bone cells.

5 Apr 2005

Tarvacin shows significant anti-viral activity

Peregrine Pharmaceuticals today announced that there will be two presentations, April 4 and 6, at the American Association of Immunologists (AAI) annual meeting in San Diego, California, indicating the anti-viral potential of its Tarvacin antibody. Dr. Melina Soares of The University of Texas Southwestern Medical Center at Dallas will present pre-clinical data titled "Targeting inside-out phospholipids on viruses in a guinea pig model of Lassa fever."

4 Apr 2005

Low levels of oral cannabis induces psychosis

Recreational cannabis use has previously been associated with psychotic reactions even in clinical situations where cannabis is administered orally at low doses, now Swiss researcher Dr. Bernard Favrat and colleagues at Institut Universitaire de Medicine Legale in Lausanne have confirmed this in the first such report, in closely monitored subjects participating in a clinical trial.

4 Apr 2005

Study of Anoxia could yield better anesthetics, stroke/heart attack recovery

For a human, mere minutes without oxygen (called anoxia) resulting from cardiac arrest, cerebral stroke or being trapped under water can lead to profound tissue damage and even death. However a Western painted turtle can survive anoxia for months without apparent tissue damage. Why, and how?

3 Apr 2005

$20 billion in cardiovascular drug revenues soon subject to patent expiration

More than $20 billion in major cardiovascular drug revenues will be exposed to patent expiration in the next three to five years, according to a report by business intelligence firm Cutting Edge Information.

30 Mar 2005

Marker for new blood vessel formation in tumors

In a paper in this month's freely-available online global health journal PLoS Medicine, Roland Haubner and colleagues describe how a compound they have developed can be used together with highly sensitive positron emission tomography (PET) scanning to measure the amount of new blood vessel growth in some tumors.

29 Mar 2005

Grapes inhibit cancer growth

Components in grapes, including some newly identified ones, work together to dramatically inhibit an enzyme crucial to the proliferation of cancer cells, say scientists at the University of Illinois at Urbana-Champaign.

29 Mar 2005

Fabric treated with an antimicrobial compound can kill dormant anthrax spores

Military textile fabric treated with an antimicrobial compound can kill dormant anthrax spores and could provide the basis for enhancing military protection in the event of a biological attack. Scientists from the U.S. Air Force Research Laboratory (Aberdeen Proving Ground, MD) reported their findings at the 2005 American Society for Microbiology Biodefense Research Meeting.

23 Mar 2005

Compound found in broccoli is a powerful disease fighter

More than 300 scientific studies point to an antioxidant found in broccoli sprouts, sulforaphane glucosinolate (SGS), as a factor in preventing multiple diseases, including several types of cancer, high blood pressure, macular degeneration and stomach ulcers.

21 Mar 2005

Demonstrating cost and clinical benefits critical to expansion of European seed brachytherapy markets

The nascent European seed brachytherapy market has been grappling with issues of high procedural and investment costs and a lack of local clinical evidence. However, growing evidence of the overall clinical and cost benefits of seed brachytherapy coupled with rising patient awareness is set to boost market expansion.

21 Mar 2005