Mutation News and Research

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New gene implicated in Parkinson can delay onset of aging, extend life span

UCLA life scientists have identified a gene previously implicated in Parkinson's disease that can delay the onset of aging and extend the healthy life span of fruit flies. The research, they say, could have important implications for aging and disease in humans.

7 May 2013

Scientists halt tumour development through genetic manipulation of cytoskeleton in fly tissues

Cancer is a complex disease, in which cells undergo a series of alterations, including changes in their architecture; an increase in their ability to divide, to survive and to invade new tissues or metastasis.

7 May 2013

Kinase inhibitors: an interview with Jan Hoflack, CSO of Oncodesign

Kinase inhibitors are molecules that block the activity of kinases. Kinases are a specific class of enzymes. They are extremely important in signal transduction processes in the human body meaning that they actually regulate most of the physiological processes that take place in the body.

7 May 2013

Study offers new hope to patients suffering from laminopathies

Laminopathies are hereditary diseases that affect mainly the muscle tissue. These diseases include for example Emery-Dreifuss Muscular dystrophy, dilated cardiomyopathy, limb-girdle muscular dystrophy and Hutchison-Gilford progeria syndrome.

7 May 2013

Mutations in Ggamma13 gene may contribute to certain forms of smell disorders in humans

Researchers at the Monell Center and collaborators have identified a protein that is critical to the ability of mammals to smell. Mice engineered to be lacking the Ggamma13 protein in their olfactory receptors were functionally anosmic - unable to smell.

7 May 2013

Mutations in phosphatase Wip1 could be a new target for treating cancer

Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new target for the treatment of certain cancers.

6 May 2013

Scientists create animal models by altering specific genes associated with a given disease

Whitehead Institute Founding Member Rudolf Jaenisch, who helped transform the study of genetics by creating the first transgenic mouse in 1974, is again revolutionizing how genetically altered animal models are created and perhaps even redefining what species may serve as models.

6 May 2013

Rare mutation confers high risk of osteoporosis and certain cancers

deCODE genetics (an Amgen subsidiary) and Illumina, global leaders in analyzing and understanding the human genome, together with scientists from the National Hospital of Iceland and the University of Iceland reported today in the journal Nature the identification of a rare nonsense mutation that confers high risk of osteoporosis and osteoporosis related traits.

6 May 2013

High levels of collagen in breasts are associated with breast cancer metastasis

Researchers at Washington University School of Medicine in St. Louis have discovered why breast cancer patients with dense breasts are more likely than others to develop aggressive tumors that spread.

6 May 2013

Gene mutation associated with rare sleep disorder also contributes to debilitating migraines

A gene mutation associated with a rare sleep disorder surprisingly also contributes to debilitating migraines, a new discovery that could change the treatment of migraines by allowing development of drugs specifically designed to treat the chronic headaches.

3 May 2013

Study: Gene mutations are associated with severe form of nearsightedness

People have long taken for granted that glasses and contact lenses improve vision for nearsightedness, but the genetic factors behind the common condition have remained blurry. Now researchers at Duke Medicine are closer to clearing this up.

3 May 2013

Scientists warn of H7N9 risks as number of cases, deaths continue to rise

"A new strain of bird flu that is causing a deadly outbreak among people in China is a threat to world health and should be taken seriously, scientists said on Wednesday," Reuters reports (Kelland, 5/1).

3 May 2013

Researchers describe alterations in long noncoding RNA sequences in Rett syndrome

Researchers at the Epigenetics and Cancer Biology Program at IDIBELL led by Manel Esteller, ICREA researcher and professor of genetics at the University of Barcelona, have described alterations in noncoding long chain RNA sequences in Rett syndrome.

3 May 2013

Researchers reveal how Ebola evades human immune response

Researchers have discovered the mechanism behind one of the Ebola virus' most dangerous attributes: its ability to disarm the adaptive immune system.

3 May 2013

Research findings suggest new treatment for breast, colon, melanoma and other cancers

A common cancer pathway causing tumor growth is now being targeted by a number of new cancer drugs and shows promising results.

3 May 2013

Study may help diagnose endometrial cancer and lead to new drug development

Endometrial tumors can be reclassified into distinct subtypes based partly on their genomic makeup and may respond to targeted drugs already being tested in clinical trials, according to a large-scale genomic analysis led by researchers at Memorial Sloan-Kettering Cancer Center and other centers within The Cancer Genome Atlas (TCGA) Research Network.

2 May 2013

Powerful data-sifting algorithms help untangle complex genetics of cancer

Powerful data-sifting algorithms developed by computer scientists at Brown University are helping to untangle the profoundly complex genetics of cancer.

2 May 2013

Study brings opportunities of personalised therapy for breast cancer a step closer

A study led by prominent breast cancer experts from Europe and the US has revealed a number of potentially important prospects for targeted therapies, and brings opportunities of truly personalised therapy for breast cancer a step closer, researchers said at the 5th IMPAKT Breast Cancer Conference in Brussels, Belgium.

2 May 2013

Genomics-based testing could change recommended course of treatment for endometrial cancer

The most in-depth look yet at endometrial cancer shows that adding genomics-based testing to the standard diagnostic workup could change the recommended course of treatment for some women.

2 May 2013

Research findings pave the way for developing better treatments for AML

A team of researchers led by Washington University School of Medicine in St. Louis has identified virtually all of the major mutations that drive acute myeloid leukemia, a fast-growing blood cancer in adults that often is difficult to treat.

2 May 2013

Mutation News and Research

New gene implicated in Parkinson can delay onset of aging, extend life span

Scientists halt tumour development through genetic manipulation of cytoskeleton in fly tissues

Kinase inhibitors: an interview with Jan Hoflack, CSO of Oncodesign

Study offers new hope to patients suffering from laminopathies

Mutations in Ggamma13 gene may contribute to certain forms of smell disorders in humans

Mutations in phosphatase Wip1 could be a new target for treating cancer

Scientists create animal models by altering specific genes associated with a given disease

Rare mutation confers high risk of osteoporosis and certain cancers

High levels of collagen in breasts are associated with breast cancer metastasis

Gene mutation associated with rare sleep disorder also contributes to debilitating migraines

Study: Gene mutations are associated with severe form of nearsightedness

Scientists warn of H7N9 risks as number of cases, deaths continue to rise

Researchers describe alterations in long noncoding RNA sequences in Rett syndrome

Researchers reveal how Ebola evades human immune response

Research findings suggest new treatment for breast, colon, melanoma and other cancers

Study may help diagnose endometrial cancer and lead to new drug development

Powerful data-sifting algorithms help untangle complex genetics of cancer

Study brings opportunities of personalised therapy for breast cancer a step closer

Genomics-based testing could change recommended course of treatment for endometrial cancer

Research findings pave the way for developing better treatments for AML

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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