Brain Metastases News and Research

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Study offers new insights into brain metastases in patients with melanoma

Brain metastasis is one of the most common causes of cancer-related deaths and occurs very frequently in patients with advanced melanoma.

18 Jul 2022

Study: Nearly 43% of patients with KRAS-mutated lung cancer respond to experimental drug adagrasib

Nearly 43% of patients with non-small cell lung cancer (NSCLC) whose lung cancers harbored a specific KRAS mutation responded to the experimental drug adagrasib, and the targeted agent also showed activity against lesions in the brain that metastasized from the lung tumors, according to results of a study led by Dana-Farber Cancer Institute investigators.

3 Jun 2022

New initiative aims to increase collaboration and accelerate high-impact cancer immunotherapy

The accelerated advancement of cancer immunology and immunotherapy, a type of biological therapy that boosts the immune system's ability to recognize and kill cancer cells, has significantly improved the effectiveness of cancer treatment and patient outcomes.

25 May 2022

Prostate cancer patients benefit from precision oncology

Researchers at the University of Bern and University Hospital Bern have achieved a breakthrough in a particularly aggressive form of prostate cancer.

11 May 2022

New guideline provides guidance on the use of radiation therapy to treat patients with brain metastases

A new clinical guideline from the American Society for Radiation Oncology provides guidance on the use of radiation therapy to treat patients with brain metastases.

10 May 2022

Researchers create models to study brain metastases that recapitulate the disease

The spreading of different types of cancer cells to the brain, forming brain metastases, is the main cause of morbidity and mortality associated to cancer. Now, a new study led by Cláudia C. Faria, principal investigator in the group of João Taborda Barata at the Instituto de Medicina Molecular João Lobo Antunes (iMM; Portugal) and neurosurgeon at the Hospital Santa Maria (HSM, CHULN, Portugal), and published today in the scientific journal Cell Reports Medicine* created a library of models to study brain metastases that recapitulate the disease in humans. These models can be a relevant tool to understand the disease and discover new therapeutical approaches tailormade to each patient.

4 May 2022

Scientists discover differences in interaction of T-cells within tumor microenvironments

A team led by Northwestern Medicine investigators has discovered differences in the distribution and interaction of T-cells within the microenvironment of different regions of both brain tumors and brain metastases, according to findings published in the journal JCI Insight.

14 Apr 2022

Alzheimer’s disease protein helps skin cancer cells thrive when they metastasize to the brain

Amyloid beta, a protein known to build up in the brains of people with Alzheimer's disease, also helps skin cancer cells thrive when they spread to the brain, a new study finds.

10 Mar 2022

Treatment with Tumor Treating Fields triggers downstream anti-tumor cell response, study finds

Novocure announced that a new study published in the Journal of Clinical Investigation (JCI) finds treatment with Tumor Treating Fields (TTFields) mediated cell disruption activates the immune system and triggers an anti-tumor cell response that may be effectively used together with existing immunotherapy approaches in the treatment of solid tumors, with limited systemic toxicity.

25 Feb 2022

New METPlatform allows researchers to test drugs for possible use in brain metastases

It is estimated that about a quarter of cancer patients are at risk of brain metastases, a rate that is increasing especially among those who suffer relapses after having undergone different cancer treatments.

17 Feb 2022

Research findings provide a potential roadmap for metastatic tumor formation

Using data from over 100,000 malignant and non-malignant cells from 15 human brain metastases, UCSF researchers have revealed two functional archetypes of metastatic cells across 7 different types of brain tumors, each containing both immune and non-immune cell types.

9 Feb 2022

Neural stem cells plus HER2 inhibitor drug improve survival in mice with metastatic cancer

Neural stem cells (NSCs) engineered by Northwestern Medicine investigators used in combination with the HER2 inhibitor drug tucatinib improved survival in mice with HER2-positive breast cancer brain metastases, according to findings published in Proceedings of the National Academy of Sciences.

1 Feb 2022

Study reveals potential new way to treat breast cancer brain metastases

A study led by researchers at RCSI University of Medicine and Health Sciences and the Beaumont RCSI Cancer Centre (BRCC) has revealed a potential new way to treat secondary breast cancer that has spread to the brain, using existing drugs.

28 Jan 2022

Metabolic vulnerabilities in malignant cells may lead to new breast cancer therapies

Metabolic differences could explain why some metastatic breast cancer cells rapidly generate tumors after migrating from primary tumors to the brain, while others linger for months or years before forming these secondary tumors, UT Southwestern scientists report in a new study.

12 Jan 2022

Combination treatment improves overall survival for melanoma patients with brain metastases

Combination treatment with immune checkpoint inhibitors nivolumab and ipilimumab demonstrates overall survival for patients with melanoma that has spread to the brain, according to Phase II study results published today in The Lancet Oncology by researchers from The University of Texas MD Anderson Cancer Center.

11 Nov 2021

Arginine treatment enhances effectiveness of radiation therapy in cancer patients with brain metastases

Treatment with arginine, one of the amino-acid building blocks of proteins, enhanced the effectiveness of radiation therapy in cancer patients with brain metastases, in a proof-of-concept, randomized clinical trial from investigators at Weill Cornell Medicine and Angel H. Roffo Cancer Institute.

7 Nov 2021

Targeted drug shows promising activity in kidney cancer patients with brain metastases

A targeted drug has shown promising activity against brain metastases resulting from kidney cancer, achieving a 50 percent response rate, and supporting further studies of the drug in this patient group whose poor prognosis has created a significant unmet need.

21 Oct 2021

Novel combination therapy identified for the brain metastases of breast cancer

A Ludwig Cancer Research study has identified and preclinically validated combination treatments for the brain metastases of breast cancer, a common and typically lethal manifestation of the malignancy.

18 Oct 2021

MR-guided focused ultrasound can safely deliver antibody therapy to Her2-positive brain metastases

In a first-in-world clinical trial, researchers at Sunnybrook Health Sciences Centre in Toronto, Canada, have demonstrated that magnetic resonance (MR)-guided focused ultrasound can be used to safely deliver antibody therapy to breast cancer that has metastasized to the brain.

13 Oct 2021

Location of brain metastasis is not random, study indicates

Brain metastasis occurs when cancer in one part of the body spreads to the brain. The lifetime incidence of such metastatic brain tumors in cancer patients is between 20%-45%, research shows.

23 Sep 2021