Drug Repurposing News and Research

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Proxalutamide shows promise as potential COVID-19 treatment

At the outset of the COVID pandemic, men appeared to suffer higher rates of severe illness and death, leading researchers to suspect a link between androgen receptors - which bind to hormones like testosterone--and SARS-CoV-2 viral infection.

18 Aug 2023

Study explores the use of existing medicines to revolutionize cancer treatment

In a recent study published in the journal of Genes & Diseases, Research team led by Lu explores the potential for the use of FDA-approved hypertension and EMA-approved cough medicines to revolutionize cancer treatment.

10 Aug 2023

New heart cell atlas reveals detailed structure of the human heart

In a new study, published today (12 July) in Nature, researchers have produced the most detailed and comprehensive human Heart Cell Atlas to date, including the specialised tissue of the cardiac conduction system - where the heartbeat originates.

12 Jul 2023

Understanding the molecular mechanisms responsible for antimony drug resistance in Leishmania parasites

Leishmaniasis is a tropical disease caused by parasites known as Leishmania, which are transmitted to humans and animals through the bites of more than 90 species of sand flies.

22 Jun 2023

Repurposed drug effective at inhibiting a protein kinase linked to cardiac arrhythmias

Ruxolitinib, a drug that is already approved by the U.S. Food and Drug Administration (FDA) for treating certain cancers and skin conditions, is effective at inhibiting CaMKII, a protein kinase linked to cardiac arrhythmias.

21 Jun 2023

Metformin shows promising antiviral activity against SARS-CoV-2

Metformin, a widely available oral medication, reduces SARS-CoV-2 viral load by 3.6-fold in outpatient trial, offering a potential treatment option. Ivermectin and fluvoxamine show no significant virologic effect.

12 Jun 2023

New model can quickly screen large libraries of potential drug compounds

Huge libraries of drug compounds may hold potential treatments for a variety of diseases, such as cancer or heart disease.

9 Jun 2023

SARS-CoV-2 hijacks body's metabolism to amplify COVID-19 severity

In a review article published in the journal Signal Transduction and Targeted Therapy, scientists have discussed host metabolic alteration triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its effect on disease severity.

9 Jun 2023

Scientists use AI to identify new antibiotic that could fight drug-resistant infections

Using an artificial intelligence algorithm, researchers at MIT and McMaster University have identified a new antibiotic that can kill a type of bacteria that is responsible for many drug-resistant infections.

25 May 2023

Different statin drugs exert different effects on COVID-19 patients

We've all recently gotten a crash-course in drug repurposing, thanks to near-daily news reports about efforts to identify existing medicines that could help treat COVID-19 in the early phase of the pandemic.

9 May 2023

Anticoronavirals: the development of COVID-19 therapies and the challenges that remain

Researchers highlighted the pace of development of COVID-19 therapies during the pandemic and the challenges that hinder the widespread availability of anticoronavirals.

8 May 2023

The decision-making process for the launch of trials for COVID-19 repurposed antivirals

Researchers reviewed the decision-making process for performing randomized clinical trials for three drugs under consideration for repurposing for COVID-19 treatment: remdesivir, molnupiravir, and tenofovir disoproxil fumarate.

30 Mar 2023

A network of interacting proteins created to aid drug discovery

Scientists at Open Targets, EMBL's European Bioinformatics Institute, and GSK are revealing the shared basis of diseases using a map of interacting human proteins.

24 Feb 2023

Migraine drug could be a potential treatment for acute kidney injury

The drug lasmiditan, which is used to treat migraines, shows promise as a possible treatment for acute kidney injury, according to a new study from the University of Arizona.

15 Feb 2023

Using 3D patient tumor avatars to guide cancer treatment decisions

At any time, most cancer patients are receiving a treatment that does not significantly benefit them while enduring bodily and financial toxicity.

20 Dec 2022

Common psychiatric medications can give some protection against COVID-19

A new meta-analysis shows that psychiatric medications can give some protection against COVID-19, with the common antidepressant fluvoxamine showing the strongest effect.

16 Dec 2022

Study aims to develop broad-spectrum antivirals against SARS-CoV-2 via drug repurposing strategies

This study aims to determine which FDA-approved compound(s) can be repurposed as a broad-spectrum antiviral drug(s) against SARS-CoV-2 and variants.

24 Nov 2022

What is the role of adenoviruses in human health?

With advances in molecular biology informing recent developments in vaccinology, gene therapy, and other fields of medicine, human adenoviruses (HAdVs) have been of primary importance in medical research. A recent review looks at the promises of HAdVs, their potential dangers, and future challenges.

9 Nov 2022

Metabolite discovery offers a potential way to address metabolic conditions

"Metabolism" describes the body's chemical changes that create the necessary materials for growth and overall health. Metabolites are the substances made and used during these metabolic processes - or, as a new discovery out of Scripps Research and its drug development arm, Calibr, indicates, they could also be potent molecules for treating severe diseases.

13 Oct 2022

Common diabetes medication identified as a possible treatment for atrial fibrillation

Cleveland Clinic researchers have identified a common diabetes medication, metformin, as a possible treatment for atrial fibrillation.

11 Oct 2022