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Neoantigen DNA vaccines improve survival and immunity in triple-negative breast cancer patients

A new phase 1 trial demonstrates the safety and effectiveness of personalized neoantigen DNA vaccines, showing promising immune responses and improved recurrence-free survival in high-risk triple-negative breast cancer patients.

17 Nov 2024

Key kinase involved in cell division linked to abnormal blood vessel growth in genetic disorder

Inhibition of CDK6 may prevent arteriovenous malformations in hereditary hemorrhagic telangiectasia by regulating endothelial cell cycle progression.

8 Nov 2024

Assessing recurrence risk with ctDNA-based MRD detection in NSCLC patients

In operable non-small cell lung cancer (NSCLC), molecular residual disease (MRD) detection via circulating tumor DNA (ctDNA) has emerged as a promising approach to identify individuals at high risk of disease recurrence and potentially guide adjuvant therapy decisions.

6 Nov 2024

Study identifies six cancer susceptibility genes

Identification of six cancer susceptibility genes offers new insights into genetic risk factors, potentially enhancing early detection and treatment strategies.

29 Oct 2024

Study uncovers six cancer susceptibility genes

Scientists at deCODE genetics/Amgen, and their collaborators have discovered six novel genes with rare germline variants that associate with cancer risk. The findings are published today in Nature Genetics under the title "Gene-based burden tests of rare germline variants identify six cancer susceptibility genes".

29 Oct 2024

Common plastic ingredient causes breaks in DNA strands and chromosome errors

A new study conducted in roundworms finds that a common plastic ingredient causes breaks in DNA strands, resulting in egg cells with the wrong number of chromosomes.

25 Oct 2024

New insights improve genetic classification for hereditary colorectal cancer

The genetic confirmation of a suspected diagnosis of "hereditary colorectal cancer" is of great importance for the medical care of affected families.

1 Oct 2024

UCLA Health researchers showcase advances in radiation oncology at ASTRO

UCLA Health Jonsson Comprehensive Cancer Center researchers and physicians who specialize in treating patients with radiation therapies will present data on the latest radiation oncology research and clinical trial results at the 66th annual American Society for Radiation Oncology (ASTRO) meeting in Washington D.C., Sept. 29 to Oct. 2.

27 Sep 2024

Breakthrough in understanding formaldehyde toxicity during development and aging

AMeD syndrome is a severe genetic condition found in children that present with accelerated aging, global developmental delay and bone marrow failure, among others, progressing to Myelodysplastic Syndrome and Acute Myeloid Leukaemia.

13 Sep 2024

Research confirms safety of breastfeeding for breast cancer survivors with BRCA mutations

According to two international studies presented at the ESMO Congress 2024, women who breastfeed after receiving treatment for breast cancer, including those with a germline BRCA mutation (an inherited change in BRCA genes that significantly increases the risk of developing certain cancers, especially breast cancer), do not face an increased risk of recurrence or developing new breast cancers.

9 Sep 2024

The significance of CHEK2 variants in cancer risk assessment

A new editorial was published in Oncotarget's Volume 15 on July 10, 2024, entitled, "Genotype matters: Personalized screening recommendations for germline CHEK2 variants."

27 Aug 2024

Study reveals RAD51D variant enrichment in Chinese ovarian cancer patients

Researchers from BGI Genomics and Fudan University published new findings on OV among Chinese patients in JCO Global Oncology.

22 Aug 2024

DDX41: A unique player in myeloid leukemogenesis

A new editorial paper was published in Oncotarget's Volume 15 on July 2, 2024, entitled, "DDX41 and its unique contribution to myeloid leukemogenesis."

19 Jul 2024

Scientists identify over 5,000 genetic variants that enable certain cancers to thrive

Researchers performed saturation genome editing of the BAP1, whose dysfunction is related to cancer and impaired neurodevelopment.

10 Jul 2024

Innovative HIV vaccine approaches yield potential for broad protection against viral strains

A major challenge in developing a vaccine for HIV is that the virus mutates fast - very fast. Although a person initially becomes infected with one or a few HIV strains, the virus replicates and mutates quickly, resulting in a "swarm" of viral strains existing in a single body.

2 Jul 2024

How random gene activity shapes lifespan in C. elegans

Why do some people live for longer than others? The genes in our DNA sequence are important, helping avoid disease or maintain general health, but differences in our genome sequence alone explain less than 30% of the natural variance of human life expectancy.

21 Jun 2024

Germline News and Research

Neoantigen DNA vaccines improve survival and immunity in triple-negative breast cancer patients

Key kinase involved in cell division linked to abnormal blood vessel growth in genetic disorder

Assessing recurrence risk with ctDNA-based MRD detection in NSCLC patients

Study identifies six cancer susceptibility genes

Study uncovers six cancer susceptibility genes

Common plastic ingredient causes breaks in DNA strands and chromosome errors

New insights improve genetic classification for hereditary colorectal cancer

UCLA Health researchers showcase advances in radiation oncology at ASTRO

Breakthrough in understanding formaldehyde toxicity during development and aging

Research confirms safety of breastfeeding for breast cancer survivors with BRCA mutations

The significance of CHEK2 variants in cancer risk assessment

Study reveals RAD51D variant enrichment in Chinese ovarian cancer patients

DDX41: A unique player in myeloid leukemogenesis

Scientists identify over 5,000 genetic variants that enable certain cancers to thrive

Innovative HIV vaccine approaches yield potential for broad protection against viral strains

How random gene activity shapes lifespan in C. elegans

Precision-guided treatment boosts outcomes in children with high-risk cancers

Inherited gene sequences predict breast cancer type and severity, study reveals

Study sheds light on the rate and nature of mutations in mitochondrial DNA

Family's rare telomere mutation reveals new insights into telomere flexibility and disease

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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