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Impulse control disorders found to be more common in people taking Parkinson's drugs

Over time, half of the people taking certain drugs for Parkinson's disease may develop impulse control disorders such as compulsive gambling, shopping or eating, according to a study published in the June 20, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology.

20 Jun 2018

UAB researchers unravel brain neuron dysfunction in Parkinson’s disease and dementia with Lewy bodies

A decay of brain function is a hallmark of Parkinson's disease and dementia with Lewy bodies, or DLB. Specifically, cognitive dysfunction defines DLB, and nearly eight of every 10 Parkinson's patients develop dementia.

11 May 2018

New study to test safety, efficacy of MRI-guided focused ultrasound to treat Parkinson's disease

University of Maryland Medicine is leading a phase 3 study to test the safety and efficacy of using MRI-guided focused ultrasound on the brain in order to treat Parkinson's disease.

13 Feb 2018

Scientists test new tactic for controlling motor complications in Parkinson's disease

Standard drug treatment for Parkinson's disease can over time induce motor complications that reduce the effectiveness of restoring mobility.

27 Jan 2018

Existing antidepressant drug could slow progression of Parkinson’s

Michigan State University scientists now have early proof that an antidepressant drug that's been around for more than 50 years could slow the progression of Parkinson's.

6 Sep 2017

Mayo Clinic study: Patients with Parkinson's have higher risk of melanoma and vice versa

People with the movement disorder Parkinson's disease have a much higher risk of the skin cancer melanoma, and vice versa, a Mayo Clinic study finds.

5 Jul 2017

Apomorphine infusion found to be effective treatment for Parkinson’s patients with motor fluctuations

Apomorphine subcutaneous infusion is an effective treatment for Parkinson patients whose motor fluctuations are poorly controlled by conventional therapies.

28 Jun 2017

Study shows evidence that old drug may provide relief for advanced Parkinson's disease patients

New research provides evidence that an old drug may provide relief for people with advanced Parkinson's, according to a study released today that will be presented at the American Academy of Neurology's 69th Annual Meeting in Boston, April 22 to 28, 2017.

20 Apr 2017

FDA approves drug as add-on treatment for Parkinson's disease patients

The U.S. Food and Drug Administration today approved Xadago (safinamide) tablets as an add-on treatment for patients with Parkinson's disease who are currently taking levodopa/carbidopa and experiencing "off" episodes.

21 Mar 2017

New infusion therapy may help avoid debilitating symptoms in Parkinson's disease patients

Constant infusion of a drug now used intermittently to "rescue" patients with Parkinson's from bouts of immobility may also help avoid these debilitating symptoms and smooth out their movement throughout the day, physician-scientists say.

14 Feb 2017

Investigational diabetes drug that impedes Parkinson's progression getting ready for human trials

A new investigational drug originally developed for type 2 diabetes is being readied for human clinical trials in search of the world's first treatment to impede the progression of Parkinson's disease following publication of research findings today in the journal Science Translational Medicine.

7 Dec 2016

Clinical trial to examine effectiveness of diabetes drug to slow or stop progression of Parkinson's

Type II diabetes and Parkinson's disease may not appear to have much in common but a look below the surface reveals important molecular similarities that provide a potential target for fighting Parkinson's.

8 Sep 2016

Research reveals new insights into happy hormone, dopamine

Dopamine is a so-called messenger substance or neurotransmitter that conveys signals between neurons.

1 Sep 2016

UAB researchers uncover vital mechanism for L-DOPA-induced-dyskinesia

Though the drug levodopa can dramatically improve Parkinson's disease symptoms, within five years one-half of the patients using L-DOPA develop an irreversible condition -- involuntary repetitive, rapid and jerky movements.

29 Jul 2016

Leukemia drug increases brain dopamine, lowers toxic proteins linked to Parkinson's or dementia

A small phase I study provides molecular evidence that an FDA-approved drug for leukemia significantly increased brain dopamine and reduced toxic proteins linked to disease progression in patients with Parkinson's disease or dementia with Lewy bodies.

12 Jul 2016

Transplantation of hpNSCs into non-human primates modeled with PD promotes behavioral recovery

A multi-center team of researchers in the U.S. testing the potential of cell therapy for treating Parkinson's disease (PD) has found that grafting human parthenogenetic stem cell-derived neural stem cells (hpNSCs) into non-human primates modeled with PD promoted behavioral recovery, increased dopamine concentrations in the brain, and induced the expression of beneficial genes and pathways when compared to control animals not transplanted with stem cells.

9 Jun 2016

NeuroDerm starts patient enrollment in long-term safety study of ND0612 for treatment of Parkinson’s disease

NeuroDerm Ltd., a clinical stage pharmaceutical company developing drugs for central nervous system disorders, today announced the start of patient enrollment in a long-term safety study (trial 012) of the company’s continuously administered subcutaneous levodopa/carbidopa formulation used in both ND0612H and ND0612L.

13 May 2016

New clinical trial focuses on respiratory drug ambroxol for treatment of Parkinson's disease

A medication approved to treat various respiratory diseases and that has demonstrated neuroprotective effects in preclinical studies is the focus of a new clinical trial for Parkinson's disease.

23 Feb 2016

Aerobic exercise training may slow progression of Parkinson's disease

You've likely heard this before: Exercise is good for you. It helps your heart, bones, back and more. But here's one thing you might not have heard: Ongoing aerobic exercise may slow the progression of Parkinson's disease, a progressive disorder of the nervous system.

20 Jan 2016

Weight loss may mark rapid Parkinson’s disease progression

Weight loss in patients with early Parkinson’s disease is associated with worsening motor function, research shows.

19 Jan 2016