Nucleotides News and Research

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Breakthrough gene silencing method slashes cholesterol for a year in mice, no DNA damage

Researchers developed an engineered transcriptional repressor that durably silences the Pcsk9 gene in mice, reducing cholesterol levels for up to a year with a single treatment, showcasing a potential breakthrough in genetic disorder treatments without the risks of DNA mutation.

29 Feb 2024

Link between gut microbiome and premature aging unveiled in chronic HIV patients

The Wistar Institute's associate professor Mohamed Abdel-Mohsen, Ph.D., has demonstrated, with his lab and collaborators, a connection between viral damage to the gut and premature biological aging.

22 Feb 2024

Novel splicing mechanism for short introns discovered

Researchers confirm that the established pre-mRNA splicing mechanism that appears in textbooks cannot work in a subset of human short introns: A novel SAP30BP–RBM17 complex-dependent splicing has been uncovered.

15 Feb 2024

Researchers identify a new approach to controlling bacterial infections

Researchers at the Icahn School of Medicine at Mount Sinai have identified a new approach to controlling bacterial infections.

7 Feb 2024

Weill Cornell Medicine researcher wins $2.1 million grant to study repetitive DNA and RNA sequences

Dr. Jeannine Gerhardt, an assistant professor of stem cell biology in obstetrics and gynecology and in reproductive medicine at Weill Cornell Medicine, has received a five-year, $2.1 million grant from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health, for the study of repetitive DNA and RNA sequences and the mechanisms by which they cause cell dysfunction and diseases.

30 Jan 2024

Ancient Brazilian genomes may hold the secrets of treponemal evolutionary history

Study reconstructs four ancient treponeme genomes from 2,000-year-old Brazilian remains, revealing their close relation to the bejel-causing Treponema pallidum endemicum and challenging previous hypotheses about treponeme subspecies adaptability.

25 Jan 2024

When mass spectrometry redefines the pharma industry

In this new episode of omg OMx, Kate Stumpo speaks to Bruker's Mike Greig about the incredible potential of mass spectrometry in pharma.

From Bruker Daltonics 12 Jan 2024

Revolutionizing diabetes care: tPBM therapy proves effective in restoring microglial health

Transcranial photobiomodulation (tPBM) treatment affected insulin therapy on microglial function.

12 Dec 2023

A step forward in vaccine technology: Exploring the effects of N1-methylpseudouridine in mRNA translation

Researchers explored how the incorporation of N1-methylpseudouridine (1-methylΨ) into mRNAs affects ribosomal frameshifting and the overall fidelity of mRNA translation.

7 Dec 2023

Researchers develop faster, cheaper, and more precise method for identifying bacteria

Researchers have developed a method that identifies bacteria easily, cheaply and more precisely than before.

28 Nov 2023

Unveiling a new cardiac myosin inhibitor through AI-driven virtual screening

Discovery of a novel cardiac-specific myosin modulator.

28 Nov 2023

Call for global action to utilize genomic surveillance to address antimicrobial resistance

During the COVID-19 pandemic, genomic surveillance proved vital in helping understand the evolution and spread of the SARS-CoV-2 virus.

14 Nov 2023

UC Riverside scientists slow progression of Huntington's disease in flies and worms

Huntington's disease causes involuntary movements and dementia, has no cure, and is fatal. For the first time, UC Riverside scientists have shown they can slow its progression in flies and worms, opening the door to human treatments.

8 Nov 2023

Unsupervised genome-wide variant effect predictor based on pretraining of DNA language models

The Genomic Pre-trained Network (GPN), a multispecies model developed to learn genome-wide variant effects.

31 Oct 2023

Study shows phages can promote mammalian cellular growth and survival

Bacteriophages, also called phages, are viruses that infect and kill bacteria, their natural hosts. But from a macromolecular viewpoint, phages can be viewed as nutritionally enriched packets of nucleotides wrapped in an amino acid shell.

26 Oct 2023

Novel GLP-1 receptor agonists offer hope for long-lasting diabetes treatment

In a study published in Scientific Reports, researchers engineer long-lasting GLP-1 receptor agonists by fusing GLP-1 with an HSA-binding protein. These chimeric molecules show promise for the treatment of type 2 diabetes due to their stability, functionality, and high affinity for the GLP-1 receptor and human serum albumin.

22 Oct 2023

Progress and challenges in completing the human gene catalogue

A group of authors reviewed the progress and challenges in annotating the human genome, including protein-coding genes, isoforms, and non-coding RNAs, and advocated for a universal annotation standard for clinical use.

5 Oct 2023

Researchers identify a rare cause of male infertility and discover a potential cure

Researchers investigated the genetic underpinning of asthenozoospermia, the leading cause of male fertility.

18 Sep 2023

Polish gulls harbor new coronavirus strains, spotlighting avian role in viral evolution

Researchers in Poland have identified five strains of gammacoronaviruses and deltacoronaviruses in black-headed and common gulls, shedding new light on the diversity and evolutionary potential of these viruses. The study highlights the need for ongoing research into animal reservoirs of coronaviruses, as they pose a risk for zoonotic transmission to humans.

17 Sep 2023

How diet and exercise may rewrite the Alzheimer's script at a molecular level

Researchers explore how lifestyle changes like diet and physical activity can influence microRNA expression in Alzheimer's patients, potentially offering new therapeutic avenues. The study fills a research gap in understanding how such lifestyle modifications could affect molecular mechanisms implicated in Alzheimer’s disease.

28 Aug 2023