Pathophysiology News and Research

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New insights into how SARS-CoV-2 evades our immune system

This review in Cellular and Molecular Immunology delves into the innate immune response to SARS-CoV-2, exploring how the virus evades immunity and the potential role of innate immunity in long-COVID and vaccine responses, shedding light on future therapeutic strategies.

23 Nov 2023

Genome study unveils genetic ties between cannabis use disorder and lung cancer risk

A genome-wide association study in Nature Genetics reveals insights into the genetics of cannabis use disorder, highlighting its strong association with psychopathology and a causal link to lung cancer, and suggesting distinct genetic pathways from mere cannabis use.

23 Nov 2023

New study reveals increased cancer risk linked to higher BMI in adults with cardiovascular diseases

The joint and individual correlations of CVD/T2D and BMI with cancer risk.

23 Nov 2023

Avian influenza A H5N1 virus impacts wide range of wildlife in the U.S., study shows

Study highlights the spread of the highly pathogenic avian influenza A (H5N1) virus among non-domesticated animals in the U.S., revealing neurological symptoms as a key clinical presentation and expanding the range of species affected by this Eurasian lineage virus.

19 Nov 2023

Molecular trap offers hope for ALS treatment

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects neurons in the brain and spinal cord causing loss of muscle control.

16 Nov 2023

Intestinal MCT1 plays a crucial role in sex-dependent metabolic regulation

Monocarboxylate transporter 1 (MCT1) plays a crucial role in the transport of lactate, pyruvate, ketone bodies, and short-chain fatty acids (SCFA), as well as MCT1-targeted drugs in various tissues.

14 Nov 2023

Obinutuzumab shows promise in preserving kidney function, preventing flares in lupus nephritis patients

In a post hoc analysis of the phase 2 NOBILITY trial, researchers found that treatment with obinutuzumab-;an antibody that targets a protein expressed on certain immune cells-;was superior to placebo for preserving kidney function and preventing flares in patients with lupus nephritis, a kidney condition associated with the autoimmune disease lupus.

10 Nov 2023

High levels of anti-Ro/SSA antibodies linked to fetal heart block in pregnant women

Some individuals with anti-Ro/SSA antibodies (anti–Sjögren's-syndrome–related antigen A autoantibodies, also called anti-Ro antibodies) have autoimmune diseases such as lupus or Sjögren's syndrome, but many have no symptoms.

10 Nov 2023

Research redefines rheumatoid arthritis: Over 314,000 cells analyzed for precise treatment strategies

A new paper recently published in Nature, reported the examination of synovial tissue from the joints of nearly 80 people with RA, in combination with RNA sequencing and surface protein analyses.

10 Nov 2023

Study links lower testosterone levels with increased arthritis risk

The relationship between serological testosterone levels and arthritis among United States (US) adults.

9 Nov 2023

Charting the future of IBD treatment: From immune modulators to microRNA therapies

In a recent study published in the journal eGastroenterology, researchers delved into the latest therapeutic strategies for managing inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The paper discusses emerging treatments ranging from immune-modulating drugs and biologics to novel approaches like microRNA upregulators and stem cell therapies, highlighting the need for precision medicine in IBD care.

8 Nov 2023

Novel and emerging therapies offer new hope for patients with inflammatory bowel disease

Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBD) that affect the gastrointestinal tract.

7 Nov 2023

Study shows depression increases disability risk in rheumatoid arthritis sufferers

The interactions between rheumatoid arthritis (RA) and major depressive disorder (MDD).

7 Nov 2023

Decoding long COVID, pathophysiology, epidemiology, diagnosis, and management

Comprehensive review unravels the complexities of long COVID, spanning pathophysiology to management strategies, and underscores the need for targeted therapies and early diagnosis.

5 Nov 2023

LMU medical scientists discover new mechanism of alarmin release

LMU medical scientists have demonstrated that important pro-inflammatory mediators are released into the bloodstream through tiny pores in the cell membrane at a very early stage of the immune response.

2 Nov 2023

Clinical trial demonstrates the effectiveness of ALS drug in treating people with acute spinal cord injuries

A small clinical trial with a pharmacokinetic sub-study, led by a world-renowned pharmacologist at the University of Houston, has demonstrated the promising effectiveness of the drug Riluzole for improving functionality in people with acute spinal cord injuries (SCI) if the drug is taken within 12 hours post-injury.

1 Nov 2023

Expert consensus on the classification of acute atherothrombotic myocardial infarction by stage of tissue injury severity

A document published in the Canadian Journal of Cardiology outlines the Canadian Cardiovascular Society's classification of acute MI.

1 Nov 2023

Managing menopause: The 2023 toolkit for healthcare practitioners

The authors of the revised 2023 Toolkit extracted key recommendations from professional guidelines and positions as well as consensus statements on menopause and related conditions that have emerged since 2014.

1 Nov 2023

New bedside cardiac assessment curriculum focuses on patient-centered learning

Bedside cardiac assessment (BCA) involves gathering a patient's medical history, performing a physical examination, and determining the need for diagnostic testing.

31 Oct 2023

Canadian Cardiovascular Society releases new heart attack classification based on heart tissue damage

The Canadian Cardiovascular Society (CCS) released the world's first classification of acute myocardial infarction (AMI), or heart attack, based on heart tissue damage research that was driven by two cardiovascular investigators within the Ischemic Heart Disease Program of Krannert Cardiovascular Research Center (KCVRC) at Indiana University School of Medicine and Northern Ontario School of Medicine.

30 Oct 2023

Pathophysiology News and Research

New insights into how SARS-CoV-2 evades our immune system

Genome study unveils genetic ties between cannabis use disorder and lung cancer risk

New study reveals increased cancer risk linked to higher BMI in adults with cardiovascular diseases

Avian influenza A H5N1 virus impacts wide range of wildlife in the U.S., study shows

Molecular trap offers hope for ALS treatment

Intestinal MCT1 plays a crucial role in sex-dependent metabolic regulation

Obinutuzumab shows promise in preserving kidney function, preventing flares in lupus nephritis patients

High levels of anti-Ro/SSA antibodies linked to fetal heart block in pregnant women

Research redefines rheumatoid arthritis: Over 314,000 cells analyzed for precise treatment strategies

Study links lower testosterone levels with increased arthritis risk

Charting the future of IBD treatment: From immune modulators to microRNA therapies

Novel and emerging therapies offer new hope for patients with inflammatory bowel disease

Study shows depression increases disability risk in rheumatoid arthritis sufferers

Decoding long COVID, pathophysiology, epidemiology, diagnosis, and management

LMU medical scientists discover new mechanism of alarmin release

Clinical trial demonstrates the effectiveness of ALS drug in treating people with acute spinal cord injuries

Expert consensus on the classification of acute atherothrombotic myocardial infarction by stage of tissue injury severity

Managing menopause: The 2023 toolkit for healthcare practitioners

New bedside cardiac assessment curriculum focuses on patient-centered learning

Canadian Cardiovascular Society releases new heart attack classification based on heart tissue damage

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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