Protein Aggregation News and Research

RSS

Researchers discover backup protein quality control mechanism

Researchers from the Babraham Institute, UK, and the German Center for Neurodegenerative Diseases (DZNE) have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail.

14 Sep 2023

Zebrafish model could help unlock Parkinson's disease mechanisms

Nearly one million people in the United States are living with Parkinson's disease, making it the second-most common neurodegenerative disease after Alzheimer's.

21 Aug 2023

The role of self-extracellular nucleic acids in neuroinflammation

Researchers explore the role of self-extracellular nucleic acids in diseases like stroke, multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease.

14 Aug 2023

Espresso compounds inhibit tau protein aggregation in preliminary in vitro tests

Whether enjoyed on its own or mixed into a latte, Americano or even a martini, espresso provides an ultra-concentrated jolt of caffeine to coffee lovers.

19 Jul 2023

Scientists uncover the structure of the first step in amyloid formation for Huntington's disease

Devastating neurodegenerative diseases like Huntington's, Alzheimer's, and Parkinson's are all associated with protein deposits in the brain, known as amyloid.

13 Jun 2023

Revolution in neuroscience: 2D nanomaterials propel advances in brain repair, treatment, and diagnosis

Review discusses the increasing importance of two-dimensional nanomaterials like graphene in neuroscience, highlighting their potential in nerve repair, creating brain-mimicking synaptic devices, and treating neurological disorders. It also considers the challenges and future prospects of these materials in this complex field.

11 Jun 2023

Extracellular chaperones mediate the lysosomal degradation of misfolded proteins

When exposed to stressful conditions, several proteins tend to misfold and form aggregates inside or outside cells.

11 May 2023

Ultra-long protein fibrils are a signature of severe Alzheimer’s disease, study shows

During the course of Alzheimer's disease, protein fibrils appear in the spinal fluid of affected individuals. Empa researchers, together with the Department of Neurology at the Cantonal Hospital in St. Gallen, have now visualized the wide spectrum of protein aggregates from oligomers, protofibrils to fibrils in the spinal fluid.

9 May 2023

Cold temperature plays a central role in longevity

Cold activates a cellular cleansing mechanism that breaks down harmful protein aggregations responsible for various diseases associated with aging.

3 Apr 2023

Exploring the neuroprotective potential of cell-penetrating peptides, extracellular vesicles, and micro ribonucleic acids

In a recent review published in Biomedicines, researchers explored extracellular vesicles (EVs), cell-penetrating peptides (CPPs), and micro ribonucleic acids (miRNAs) as therapies for neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD).

1 Mar 2023

A possible link between aggregation of SARS-CoV-2 proteins and protein misfolding diseases

A new study in the journal Nature Communications aimed to analyze the aggregation propensity in the proteins of both SARS-CoV-2 and SARS-CoV.

21 Feb 2023

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Researchers presented eight hallmarks of neurodegenerative diseases (NDDs), their in vivo biomarkers, and interactions to help categorize NDDs and specify patients within a specific NDD.

21 Feb 2023

Nanopore-based sensing device can provide volume information about tau and tubulin proteins

Tau and tubulin proteins are one of the leading causes of many neurodegenerative diseases, such as Alzheimer's and Parkinson's.

10 Jan 2023

Newly identified genetic mutation may be a root cause of severe childhood glaucoma

An international team of scientists led by Mass Eye and Ear, a member of Mass General Brigham, and Boston Children's Hospital, has discovered a new genetic mutation that may be a root cause of severe cases of childhood glaucoma, a devastating condition that runs in families and can rob children of their vision by 3 years of age.

1 Dec 2022

The roles of innate and adaptive immunity in Alzheimer’s disease development and progression

Researchers reviewed research advancements showing the significant role both innate and adaptive immune systems play in the pathological course of Alzheimer’s disease.

10 Nov 2022

Research shows how a very low dose of rhenium metal complex kills ovarian cancer cells

Metal-containing complexes have taken up center stage in the search for new cancer drugs that are as free of side effects as possible.

12 Oct 2022

Repligen expands process analytics portfolio with DRS Daylight Solutions agreement

Repligen Corporation, a life sciences company focused on bioprocessing technology leadership, today announced it has entered into a strategic partnership and exclusive license agreement with DRS Daylight Solutions to expand the use of mid-infrared (mid-IR) technology in the bioprocessing market.

From Daylight Solutions Inc 22 Sep 2022

SARS-CoV-2 generates amyloid in cerebral spinal fluid

In a recent study posted to the bioRxiv* preprint server, an international team of researchers demonstrated amyloid aggregation due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human cerebrospinal fluid (CSF).

20 Sep 2022

Molecular probes can track the progress of protein that misbehaves in neurodegenerative diseases

A team of researchers from the IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) has designed in silico "molecular probes" able to track the progress of a protein that misbehaves in different neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS) and Fronto-Temporal Dementia (FTD).

9 Sep 2022

Alzheimer’s disease is associated with characteristic gut metabolomic signatures

Scientists review current literature associated with the role of the gut-brain axis in AD pathogenesis.

9 Aug 2022