Protein Aggregation News and Research

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Data, Design, and Discovery: Andrew Buchanan's Impact on Biologics Innovation

Andrew Buchanan on the Future of Biologics and AI

10 Nov 2023

DZNE neuroscientist awarded 1.5 million euros to investigate biophysical phenomena relevant to brain diseases

Dr. Dragomir Milovanovic, a neuroscientist at DZNE's Berlin site, has been awarded an European Research Council (ERC) "Starting Grant" worth 1.5 million euros to investigate biophysical phenomena relevant to brain diseases in a groundbreaking research project.

7 Nov 2023

A comprehensive database developed to help understand the basis of protein aggregation

Researchers at the IBB-UAB have developed the most comprehensive database available to date to help understand the basis of protein aggregation, a phenomenon associated with aging and several pathologies.

3 Nov 2023

Is COVID-19 a risk factor for Alzheimer's disease?

The study explores the interconnected risks between COVID-19 and Alzheimer's Disease (AD), highlighting how SARS-CoV-2 can aggravate AD pathology through neuroinflammation and neurodegeneration. It raises significant concerns about the long-term cognitive implications of COVID-19, especially among those already at risk for AD.

23 Oct 2023

New AI model can identify neuroanatomical regions vulnerable to age-related changes

The aging brain undergoes structural and cellular changes that can impact function and increase susceptibility to neurodegenerative disorders like Alzheimer's disease.

11 Oct 2023

Does smoking tobacco damage sperm quality?

Tobacco smoking is linked to diminished semen quality by triggering stress reactions in sperm cells, a study in the journal Antioxidants reveals. Researchers identified that smokers had poorer sperm quality, possibly due to elevated stress responses in their sperm cells.

8 Oct 2023

Researchers discover backup protein quality control mechanism

Researchers from the Babraham Institute, UK, and the German Center for Neurodegenerative Diseases (DZNE) have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail.

14 Sep 2023

Zebrafish model could help unlock Parkinson's disease mechanisms

Nearly one million people in the United States are living with Parkinson's disease, making it the second-most common neurodegenerative disease after Alzheimer's.

21 Aug 2023

The role of self-extracellular nucleic acids in neuroinflammation

Researchers explore the role of self-extracellular nucleic acids in diseases like stroke, multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease.

14 Aug 2023

Espresso compounds inhibit tau protein aggregation in preliminary in vitro tests

Whether enjoyed on its own or mixed into a latte, Americano or even a martini, espresso provides an ultra-concentrated jolt of caffeine to coffee lovers.

19 Jul 2023

Scientists uncover the structure of the first step in amyloid formation for Huntington's disease

Devastating neurodegenerative diseases like Huntington's, Alzheimer's, and Parkinson's are all associated with protein deposits in the brain, known as amyloid.

13 Jun 2023

Revolution in neuroscience: 2D nanomaterials propel advances in brain repair, treatment, and diagnosis

Review discusses the increasing importance of two-dimensional nanomaterials like graphene in neuroscience, highlighting their potential in nerve repair, creating brain-mimicking synaptic devices, and treating neurological disorders. It also considers the challenges and future prospects of these materials in this complex field.

11 Jun 2023

Extracellular chaperones mediate the lysosomal degradation of misfolded proteins

When exposed to stressful conditions, several proteins tend to misfold and form aggregates inside or outside cells.

11 May 2023

Cold temperature plays a central role in longevity

Cold activates a cellular cleansing mechanism that breaks down harmful protein aggregations responsible for various diseases associated with aging.

3 Apr 2023

Exploring the neuroprotective potential of cell-penetrating peptides, extracellular vesicles, and micro ribonucleic acids

In a recent review published in Biomedicines, researchers explored extracellular vesicles (EVs), cell-penetrating peptides (CPPs), and micro ribonucleic acids (miRNAs) as therapies for neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD).

1 Mar 2023

A possible link between aggregation of SARS-CoV-2 proteins and protein misfolding diseases

A new study in the journal Nature Communications aimed to analyze the aggregation propensity in the proteins of both SARS-CoV-2 and SARS-CoV.

21 Feb 2023

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Researchers presented eight hallmarks of neurodegenerative diseases (NDDs), their in vivo biomarkers, and interactions to help categorize NDDs and specify patients within a specific NDD.

21 Feb 2023

Nanopore-based sensing device can provide volume information about tau and tubulin proteins

Tau and tubulin proteins are one of the leading causes of many neurodegenerative diseases, such as Alzheimer's and Parkinson's.

10 Jan 2023

Newly identified genetic mutation may be a root cause of severe childhood glaucoma

An international team of scientists led by Mass Eye and Ear, a member of Mass General Brigham, and Boston Children's Hospital, has discovered a new genetic mutation that may be a root cause of severe cases of childhood glaucoma, a devastating condition that runs in families and can rob children of their vision by 3 years of age.

1 Dec 2022

The roles of innate and adaptive immunity in Alzheimer’s disease development and progression

Researchers reviewed research advancements showing the significant role both innate and adaptive immune systems play in the pathological course of Alzheimer’s disease.

10 Nov 2022