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Novel monoclonal antibody appears effective at neutralizing numerous SARS-CoV-2 variants

A monoclonal antibody appears effective at neutralizing the numerous variants of SARS-CoV-2, as well as related viruses in animals that could pose a threat if they were to begin spreading in people.

6 Sep 2024

Mucosal COVID-19 boosters outperform mRNA shots in preventing upper airway infections

Aerosolized mucosal vaccines show promise in controlling SARS-CoV-2, offering greater protection and immune response than intramuscular bivalent mRNA boosters.

5 Sep 2024

Newly discovered antibody can neutralize all known variants of SARS-CoV-2

Researchers have discovered an antibody able to neutralize all known variants of SARS-CoV-2, the virus that causes COVID-19, as well as distantly related SARS-like coronaviruses that infect other animals.

3 Sep 2024

Intranasal vaccine shows broad SARS-CoV-2 variant protection

Study demonstrates that a single-dose intranasal live-attenuated vaccine, CDO-7N-1, provides broad protection against SARS-CoV-2 and its variants by inducing potent immune responses, including neutralizing antibodies and T-cell activity, in animal models.

1 Sep 2024

Fibrin fuels thromboinflammation and brain damage in COVID-19

Researchers reveal fibrin's critical role in COVID-19 by driving thromboinflammation and neuropathology, and highlight a potential antibody therapy to mitigate these effects.

29 Aug 2024

Study reveals the role of blood clotting in COVID-19

In a study that reshapes what we know about COVID-19 and its most perplexing symptoms, scientists have discovered that the blood coagulation protein fibrin causes the unusual clotting and inflammation that have become hallmarks of the disease, while also suppressing the body's ability to clear the virus.

29 Aug 2024

Analysis reveals viral shift behind COVID-19 pandemic end

New analysis suggests that a dramatic drop in deaths from COVID-19 between 2022 and 2023 could be attributed to an abrupt phase transition in the molecular structure of the virus' spike protein.

28 Aug 2024

New intranasal COVID-19 vaccine promises broad protection and accessibility

A next-generation COVID-19 mucosal vaccine is set to be a gamechanger not only when delivering the vaccine itself, but also for people who are needle-phobic.

27 Aug 2024

Mutation in SARS-CoV-2 spike protein enhances brain infection

Scientists have discovered a mutation in SARS-CoV-2, the virus that causes COVID-19, that plays a key role in its ability to infect the central nervous system.

23 Aug 2024

New insights into COVID-19 spike protein offer hope for universal vaccines

A team led by Jose Onuchic at Rice University and Paul Whitford at Northeastern University, both researchers at the National Science Foundation Physics Frontiers Center at the Center for Theoretical Biological Physics (CTBP) at Rice, has made a discovery in the fight against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus responsible for COVID-19.

16 Aug 2024

Mucosal COVID-19 vaccine prevents airborne transmission of SARS-CoV-2

The impact of mucosal versus intramuscular vaccine immunization on airborne infection and transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Syrian hamsters.

5 Aug 2024

Hamster sera study reveals Omicron subvariants' vast antigenic diversity

Study developed an antigenic map of SARS-CoV-2 variants using hamster sera, revealing substantial antigenic variation among Omicron subvariants and highlighting their distinct immune escape capabilities.

1 Aug 2024

More types of lung cells can be infected by SARS-CoV-2 than previously thought, scientists report

Scientists at Sanford Burnham Prebys, University of California San Diego and their international collaborators have reported that more types of lung cells can be infected by SARS-CoV-2 than previously thought, including those without known viral receptors.

23 Jul 2024

Understanding the new coronavirus mutant strain KP.3.1.1

Researchers in Japan evaluated the SARS-CoV-2 KP.3.1.1 variant, finding it has higher transmissibility and immune evasion compared to previous variants, posing new challenges for public health measures.

22 Jul 2024

How does SARS-CoV-2 cause lymphopenia when T cells barely express ACE-2 receptors?

Researchers reveal both direct and indirect mechanisms of SARS-CoV-2-induced lymphopenia, highlighting the role of CD147 and alternative viral entry routes into T cells.

8 Jul 2024

Innovative HIV vaccine approaches yield potential for broad protection against viral strains

A major challenge in developing a vaccine for HIV is that the virus mutates fast - very fast. Although a person initially becomes infected with one or a few HIV strains, the virus replicates and mutates quickly, resulting in a "swarm" of viral strains existing in a single body.

2 Jul 2024

New host factors identified as important for SARS-CoV-2 infection

A research team led by Prof. Guo Yusong, Associate Professor of the Division of Life Science at the Hong Kong University of Science and Technology (HKUST), recently made a novel discovery related to the coronavirus (SARS-CoV-2) that causes COVID-19.

2 Jul 2024

Regular booster doses of bivalent mRNA COVID-19 vaccines help neutralize multiple strains

People who have received solid organ transplants and take immunosuppressant medications to prevent rejection are among those most susceptible to the damaging effects of COVID-19, including breakthrough infections, severe illness, hospitalization and death.

2 Jul 2024

NIH launches Phase 1 trial for innovative nasal COVID-19 vaccine

A Phase 1 trial testing the safety of an experimental nasal vaccine that may provide enhanced breadth of protection against emerging variants of SARS-CoV-2, the virus that causes COVID-19, is now enrolling healthy adults at three sites in the United States.

1 Jul 2024

At-home antibody tests could drive higher COVID-19 booster rates, new research finds

The feasibility and benefits of lateral flow assay (LFA)-based antibody tests for detecting inadequate COVID-19 immunity.

17 Jun 2024

Spike Protein News and Research

Novel monoclonal antibody appears effective at neutralizing numerous SARS-CoV-2 variants

Mucosal COVID-19 boosters outperform mRNA shots in preventing upper airway infections

Newly discovered antibody can neutralize all known variants of SARS-CoV-2

Intranasal vaccine shows broad SARS-CoV-2 variant protection

Fibrin fuels thromboinflammation and brain damage in COVID-19

Study reveals the role of blood clotting in COVID-19

Analysis reveals viral shift behind COVID-19 pandemic end

New intranasal COVID-19 vaccine promises broad protection and accessibility

Mutation in SARS-CoV-2 spike protein enhances brain infection

New insights into COVID-19 spike protein offer hope for universal vaccines

Mucosal COVID-19 vaccine prevents airborne transmission of SARS-CoV-2

Hamster sera study reveals Omicron subvariants' vast antigenic diversity

More types of lung cells can be infected by SARS-CoV-2 than previously thought, scientists report

Understanding the new coronavirus mutant strain KP.3.1.1

How does SARS-CoV-2 cause lymphopenia when T cells barely express ACE-2 receptors?

Innovative HIV vaccine approaches yield potential for broad protection against viral strains

New host factors identified as important for SARS-CoV-2 infection

Regular booster doses of bivalent mRNA COVID-19 vaccines help neutralize multiple strains

NIH launches Phase 1 trial for innovative nasal COVID-19 vaccine

At-home antibody tests could drive higher COVID-19 booster rates, new research finds

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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