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Liraglutide cardioprotective in high-risk Type 2 diabetes patients

Findings of the LEADER trial show that liraglutide treatment may confer a reduced risk of cardiovascular events in patients with Type 2 diabetes and a high vascular risk.

15 Jun 2016

Liraglutide drug effectively decreases cardiovascular disease risk in type 2 diabetes patients

Researchers have shown that the glucose-lowering drug liraglutide safely and effectively decreases the overall risk of heart attack, stroke, or cardiovascular death for people with type 2 diabetes.

14 Jun 2016

Liraglutide enhances high-dose insulin treatment in Type 2 diabetes

The addition of the glucagon-like peptide 1 receptor agonist liraglutide improves short-term outcomes and treatment satisfaction in patients who have uncontrolled Type 2 diabetes despite high doses of insulin, shows a randomised trial.

12 Jun 2016

Study establishes copper’s role in fat metabolism

A new study is further burnishing copper's reputation as an essential nutrient for human physiology. A research team led by a scientist at the Department of Energy's Lawrence Berkeley National Laboratory and at the University of California, Berkeley, has found that copper plays a key role in metabolizing fat.

7 Jun 2016

Stimulating STING pathway to provoke life-extending immune response shows promise in AML

A protein known as STING plays a crucial role in the immune system's ability to "sense" cancer by recognizing and responding to DNA from tumor cells. Injection of compounds that activate the STING pathway directly into solid tumors in mice has been shown in prior studies to result in very potent anti-tumor immune responses.

3 Jun 2016

New technique could help reduce chances of drug failure during later stages of clinical trials

An approach that could reduce the chances of drugs failing during the later stages of clinical trials has been demonstrated by a collaboration between the University of Cambridge and pharmaceutical company GlaxoSmithKline.

2 Jun 2016

Study provides new insights into molecular basis of CaSR-related human diseases

A study led by researchers at Georgia State University provides new insights into the molecular basis of human diseases resulting from mutations in the calcium-sensing receptor (CaSR), a protein found in cell membranes.

1 Jun 2016

Vitamin D and androgen receptor-targeted therapy may help treat TNBC

A recent study by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine revealed that triple-negative breast cancer (TNBC), which has generally been unresponsive to hormone receptor-targeted treatments, can indeed be treated using vitamin D and androgen receptor-targeted therapy.

24 May 2016

Nanoparticle-based gene therapy may hold promise for patients with asthma

A new study has demonstrated a way to deliver a nanoparticle-based gene therapy, in order to repair lungs damaged by chronic allergic asthma and to reduce inflammation that causes asthma attacks.

19 May 2016

Researchers highlight need for more tailored approaches to treating chronic obstructive pulmonary disease

Speakers at the recent REG 2016 Summit highlighted the need for more research into the nature and effectiveness of treatment for COPD (Chronic Obstructive Pulmonary Disease) in a real-world environment.

16 May 2016

New study shows women susceptible to pain-relieving placebo effect of vasopressin

A new study in the current issue of Biological Psychiatry suggests that women are particularly susceptible to the pain-relieving placebo effect of vasopressin.

3 May 2016

Derivatives of female sex hormones can influence natural melanin production, study suggests

When skin cells responsible for pigmentation are exposed to estrogen or progesterone, the cells respond by adjusting their melanin production, resulting in either skin darkening or lightening. Although pregnant women often experience alterations in skin pigmentation, the reason for the changes has long puzzled physicians.

27 Apr 2016

HDM SLIT tablet can reduce risk of moderate or severe asthma exacerbation

The addition of a house dust mite (HDM) sublingual allergen immunotherapy (SLIT) tablet to maintenance medications improved time to first moderate or severe asthma exacerbation during a period of inhaled corticosteroid (ICS) reduction among adults with HDM allergy-related asthma not well controlled by ICS, according to a study appearing in the April 26 issue of JAMA.

27 Apr 2016

Endocrine Society urges physicians to increase screening for primary aldosteronism

The Endocrine Society today issued a Clinical Practice Guideline calling on physicians to ramp up screening for primary aldosteronism, a common cause of high blood pressure.

27 Apr 2016

GLP-1 receptor agonist may benefit high-risk diabetes

Research shows that using a glucagon-like peptide-1 receptor agonist instead of a rapid-acting insulin analogue at mealtimes can reduce glycaemic variability in high-risk patients with Type 2 diabetes.

26 Apr 2016

Researchers use BMG LABTECH's microplate readers to measure binding events in kinetic over minutes

Single reading events of a signaling molecule at a given time should no longer be considered as the only insightful indicator to predict the usefulness of a new drug candidate.

From BMG LABTECH GmbH 19 Apr 2016

Palovarotene drug may prevent multiple musculoskeletal problems linked with FOP

New research in laboratory animals suggests that the drug palovarotene may prevent multiple skeletal problems caused by a rare but extremely disabling genetic bone disease, and may even be a candidate for use in newborn babies with the condition.

15 Apr 2016

Cigarette smoking, viral infections may reduce effectiveness of COPD symptom-reliever medication

New study backs up observations in Chronic Obstructive Pulmonary Disease (COPD) patients showing reduced effectiveness of symptom-reliever medication (β2-adrenoceptor agonists) in flare-ups linked to cigarette smoking and infection with viruses such as influenza.

11 Apr 2016

Ludwig, CRI launch Phase 1/2 trial of combination immunotherapy for advanced ovarian cancer

Ludwig Cancer Research and the Cancer Research Institute have launched a Phase 1/2 clinical trial of combination immunotherapy for advanced ovarian cancer. The international, multicenter trial is led by George Coukos, director of the Ludwig Institute for Cancer Research, Lausanne and Brad Monk, director of Gynecologic Oncology at St. Joseph's Hospital and Medical Center.

7 Apr 2016

Parkinson's disease medications could lead to impulse control disorders

Drugs commonly prescribed to treat Parkinson's disease have been linked to impulse control disorders such as pathological gambling, compulsive buying, hypersexuality and binge eating in some patients, report neurologists from Loyola Medicine and Loyola University Chicago Stritch School of Medicine.

6 Apr 2016

Agonist News and Research

Liraglutide cardioprotective in high-risk Type 2 diabetes patients

Liraglutide drug effectively decreases cardiovascular disease risk in type 2 diabetes patients

Liraglutide enhances high-dose insulin treatment in Type 2 diabetes

Study establishes copper’s role in fat metabolism

Stimulating STING pathway to provoke life-extending immune response shows promise in AML

New technique could help reduce chances of drug failure during later stages of clinical trials

Study provides new insights into molecular basis of CaSR-related human diseases

Vitamin D and androgen receptor-targeted therapy may help treat TNBC

Nanoparticle-based gene therapy may hold promise for patients with asthma

Researchers highlight need for more tailored approaches to treating chronic obstructive pulmonary disease

New study shows women susceptible to pain-relieving placebo effect of vasopressin

Derivatives of female sex hormones can influence natural melanin production, study suggests

HDM SLIT tablet can reduce risk of moderate or severe asthma exacerbation

Endocrine Society urges physicians to increase screening for primary aldosteronism

GLP-1 receptor agonist may benefit high-risk diabetes

Researchers use BMG LABTECH's microplate readers to measure binding events in kinetic over minutes

Palovarotene drug may prevent multiple musculoskeletal problems linked with FOP

Cigarette smoking, viral infections may reduce effectiveness of COPD symptom-reliever medication

Ludwig, CRI launch Phase 1/2 trial of combination immunotherapy for advanced ovarian cancer

Parkinson's disease medications could lead to impulse control disorders

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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