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A night without sleep alters neural connections in human brains

A night without sleep produced increased markers of connections between brain cells, showing that sleep in humans may be important for restoring cellular balance in the brain, according to a study published June 23rd in the open access journal PLOS Biology by David Elmenhorst from the Forschungszentrum Jülich Institute of Neuroscience and Medicine in North Rhine-Westphalia, Germany, and colleagues.

23 Jun 2026

Scientists uncover new molecular mechanism driving gastrointestinal stromal tumors

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract, with KIT mutations driving approximately 75% to 80% of cases.

23 Jun 2026

USC study links modified Mediterranean diet to longer lifespan

A plant- and fish-based, low-protein diet paired with small amounts of an amino acid commonly found in eggs, meat and dairy increased healthy lifespan and decreased frailty and fat mass in mice, according to a new USC study published today in the journal Cell Metabolism.

23 Jun 2026

MSU researchers develop tool to observe complex molecular choreography in real time

A lot of things need to go right on a molecular level for immune cells to launch an adaptive response to an infection.

23 Jun 2026

New study identifies brain circuits behind spontaneous and voluntary laughter

Laughter is a universal social signal that connects us with others, but the brain regions underlying laughter are not well understood, in part because it's hard to elicit genuine laughter in the lab.

23 Jun 2026

Researchers identify molecular cause of age-related cognitive decline

A research team from University Hospitals, Case Western Reserve University and the Louis Stokes Cleveland VA Medical Center has identified a critical molecular cause of age-related cognitive decline, potentially paving the way for new treatments to protect brain health as we age.

23 Jun 2026

Skin barrier monitoring predicts necrosis after skin flap surgery

Random-pattern skin flaps (RPSFs) receive blood mainly from small subcutaneous vessels rather than a defined axial vessel, leaving them vulnerable to ischemia and hypoxia after surgery.

23 Jun 2026

UCI Health launches world's first embryonic stem cell trial for Huntington's disease

UCI Health, the clinical enterprise of the University of California, Irvine, has opened the world's first in-human embryonic stem cell-derived clinical trial for Huntington's disease.

23 Jun 2026

Artificial intelligence helps breast cancer patients avoid unnecessary chemotherapy

Research led by RCSI University of Medicine and Health Sciences and University College Dublin (UCD) has identified immune markers that could help doctors more accurately determine which breast cancer patients are unlikely to benefit from chemotherapy, potentially sparing some patients from unnecessary treatment.

23 Jun 2026

Cytoskeletal proteins in the cell nucleus influence brain development

The cytoskeleton gives cells their shape and helps them move. Researchers at Helmholtz Munich and the Ludwig Maximilian University now show that, in neural stem cells, proteins of the cytoskeleton are also found in the cell nucleus, where they can influence developmental programs.

23 Jun 2026

New project aims to systematically map billion cellular interactions

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23 Jun 2026

New TRUECAM wrapper makes medical artificial intelligence more trustworthy

Medical artificial intelligence (AI) faces a fundamental challenge: uncertainty quantification. Artificial neural networks are largely unaware of the limits of their training data and can become overconfident when confronted with unfamiliar inputs. Suppose you train a neural network to distinguish among African mammals.

23 Jun 2026

Trial identifies 4 grams a day as the tested safe level for L-tyrosine in healthy men

A randomized, crossover trial in healthy adult men found that 4 weeks of L-tyrosine supplementation at doses up to 4 g/day did not cause clinically meaningful changes in safety markers, diet, blood pressure, or body measures. The highest tested dose, 4 g/day, was identified as the no-observed-adverse-effect level under the study’s four-week conditions, although broader and longer-term studies are still needed.

23 Jun 2026

New AI platform tracks cancer treatment responses in tumor organoids

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have developed a new platform that combines 3D bioprinting, advanced imaging and artificial intelligence to better monitor how cancer responds to treatment.

22 Jun 2026

Statins may trigger muscle side effects by activating inflammatory danger signals

An experimental study in Science Advances shows that statins, primarily fluvastatin in these experiments, may promote low-level muscle myopathy by reducing isoprenoid-dependent protein prenylation rather than by cholesterol lowering. In primed muscle cells and mouse models, impaired YAP signaling, reduced glycolysis, NLRP3/caspase-1 activation, and nuclear FOXO accumulation increased atrogin-1, reduced protein synthesis, and weakened muscle function.

22 Jun 2026

Scientists trace cardiac aging to a fading regulator in heart muscle cells

Researchers mapped 442,239 single nuclei from nonfailing human hearts to chart how cardiac cells change from fetal development to older adulthood. The study identified PRDM16 as an age-declining cardiomyocyte regulator, with experimental evidence showing that restoring Prdm16 in aged mouse hearts improved systolic function and partly reversed aging-associated transcriptional patterns.

22 Jun 2026

Prime and pull vaccine approach prevents genital herpes infection

Genital herpes is a lifelong infection. While available treatments can manage symptoms, they cannot cure the infection or prevent transmission.

22 Jun 2026

UCLA researcher receives grant for advanced osteosarcoma immunotherapy

Physician-scientist Theodore Scott Nowicki, MD, PhD, an assistant professor in the department of pediatrics hematology/oncology and microbiology, immunology, & molecular genetics at the David Geffen School of Medicine at UCLA, has been awarded the Hero Grant from MIB Agents, a nonprofit organization dedicated to improving outcomes for children and young adults with osteosarcoma.

22 Jun 2026

Natural molecule erucamide helps slow progressive retinal degeneration

Many conditions that cause vision loss share a common feature: the gradual breakdown of the retina, the light-sensing tissue at the back of the eye.

22 Jun 2026

Optimized proximity labeling platform tracks cellular protein communication networks

The body's organs are in constant communication. Fat tissue tells the liver when to store or release energy, the immune system signals localized inflammation, and thousands of proteins carry these messages to organs throughout the body.

22 Jun 2026