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Innate immune cells of myeloid lineage play central role in AD pathogenesis than previously thought

Many genes linked to late-onset Alzheimer's disease (AD) are expressed in myeloid cells and regulated by a single protein, according to research conducted at the Icahn School of Medicine at Mount Sinai and published June 19 in the journal Nature Neuroscience.

27 Jun 2017

Researchers discover broad role for DNA-cutting enzyme in driving abnormal genetic rearrangements

Researchers studying a DNA-cutting enzyme with a crucial role in regulating the structure of genes have discovered a broad role for its cutting activity in driving abnormal genetic rearrangements called translocations that cause cancer, including leukemias and solid tumors.

16 Jun 2017

Mutations identified that enable human transmission of avian flu

A systematic mutation analysis has shown that changes in just three amino acids of the avian influenza H7N9 virus receptor binding protein confers specificity for human cells.

16 Jun 2017

Penn/CHOP research helps to better understand cause of pediatric and treatment-related leukemias

Certain pediatric leukemias share a common underlying cause with treatment-related secondary leukemias.

16 Jun 2017

Rice University scientists develop and evaluate analogs of potent cancer fighters

Rice University scientists have developed and evaluated analogs of potent anti-tumor agents known as epothilones using designs and methods that both improve their biological properties and simplify their manufacture.

31 May 2017

Study points to new pharmacologic approach to target chemo-resistant lung cancer

Patients with non-small cell lung cancer (NSCLC) often respond to standard chemotherapy, only to develop drug resistance later, and with fatal consequences.

23 May 2017

Breast cancer cells undergo stiffening state prior to becoming malignant, study shows

A study published now on Nature Communications shows that breast cancer cells undergo a stiffening state prior to acquiring malignant features and becoming invasive.

16 May 2017

Recurrence of HPV-negative HNSCC after radiation therapy linked to high tumor levels of PD-L1 protein

Recurrence of head and neck squamous cell carcinoma (HNSCC) negative for human papillomavirus (HPV) following radiation therapy was associated with high tumor levels of the protein PD-L1.

5 May 2017

China creates new kinase-based whole-cell screening library for high-throughput drug assay

After five years of hard work, China has completed the world's largest kinase-based whole-cell screening library for high-throughput drug assay.

28 Apr 2017

Study underscores need for genetic screening to improve safety of experimental stem cell treatments

Regenerative medicine using human pluripotent stem cells to grow transplantable tissue outside the body carries the promise to treat a range of intractable disorders, such as diabetes and Parkinson's disease.

26 Apr 2017

New model for toxicity risk assessment could reduce reliance on animal testing

Traditional toxicological investigations performed on animals (in vivo) are expensive, time-consuming and may cause animal suffering.

24 Apr 2017

Strawberry extract can inhibit spread of breast cancer cells, mice study shows

A study by European and Latin American researchers has shown that strawberry extract can inhibit the spread of laboratory-grown breast cancer cells, even when they are inoculated in female mice to induce tumours.

19 Apr 2017

Salk scientists discover chemical cocktail that enables stem cells to generate tissues

When scientists talk about laboratory stem cells being totipotent or pluripotent, they mean that the cells have the potential, like an embryo, to develop into any type of tissue in the body.

6 Apr 2017

Researchers propose novel theory of how some cancers circumvent killing power of targeted therapies

Nearly 50 years into the "war" on cancer, doctors possess weapons that once would have seemed magical in their tumor-killing specificity.

29 Mar 2017

Researchers identify odorant troenan that can inhibit colorectal cancer growth

Growth of colorectal cancer cells can be inhibited with the odorant troenan. This is reported by the research team headed by Prof Dr Dr Dr habil. Hanns Hatt and Dr Lea Weber from Ruhr-Universität Bochum in the journal "PLOS One".

23 Mar 2017

Efficacy of innovative gene therapy can be tested quickly and cost-effectively using new cellular model

Using a new cellular model, innovative gene therapy approaches for the hereditary immunodeficiency Chronic Granulomatous Disease can be tested faster and cost-effectively in the lab for their efficacy.

21 Mar 2017

Dietary anti-cancer compound from broccoli may work by influence on long non-coding RNAs

Researchers have discovered one of the reasons why broccoli may be good for your health.

16 Mar 2017

Antibody treats pediatric brain tumors safely and effectively in mice

Five types of pediatric brain cancer were safely and effectively treated in mice by an antibody that causes immune cells to engulf and eat tumors without hurting healthy brain cells, according to a new study by researchers at the Stanford University School of Medicine.

15 Mar 2017

LCSB researchers identify how the body influences differentiation of progenitor cells

Stem cells are unspecialised cells that can develop into any type of cell in the human body. So far, however, scientists only partially understand how the body controls the fate of these all-rounders, and what factors decide whether a stem cell will differentiate, for example, into a blood, liver or nerve cell.

15 Mar 2017

Researchers take important step forward in disabling cancer cells' defences

Recent study out of the University of Ottawa opens door for new disease therapies in cancer, ALS, Fragile X Syndrome and others.

10 Mar 2017

Cell Line News and Research

Innate immune cells of myeloid lineage play central role in AD pathogenesis than previously thought

Researchers discover broad role for DNA-cutting enzyme in driving abnormal genetic rearrangements

Mutations identified that enable human transmission of avian flu

Penn/CHOP research helps to better understand cause of pediatric and treatment-related leukemias

Rice University scientists develop and evaluate analogs of potent cancer fighters

Study points to new pharmacologic approach to target chemo-resistant lung cancer

Breast cancer cells undergo stiffening state prior to becoming malignant, study shows

Recurrence of HPV-negative HNSCC after radiation therapy linked to high tumor levels of PD-L1 protein

China creates new kinase-based whole-cell screening library for high-throughput drug assay

Study underscores need for genetic screening to improve safety of experimental stem cell treatments

New model for toxicity risk assessment could reduce reliance on animal testing

Strawberry extract can inhibit spread of breast cancer cells, mice study shows

Salk scientists discover chemical cocktail that enables stem cells to generate tissues

Researchers propose novel theory of how some cancers circumvent killing power of targeted therapies

Researchers identify odorant troenan that can inhibit colorectal cancer growth

Efficacy of innovative gene therapy can be tested quickly and cost-effectively using new cellular model

Dietary anti-cancer compound from broccoli may work by influence on long non-coding RNAs

Antibody treats pediatric brain tumors safely and effectively in mice

LCSB researchers identify how the body influences differentiation of progenitor cells

Researchers take important step forward in disabling cancer cells' defences

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