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A summary of SARS-CoV-2 RNA-protein interactome studies

A new study summarized the importance of SARS-CoV-2 ribonucleic acid protein interactomes in the study of RNA viruses.

30 Mar 2022

IgG Fc glycosylation: A marker for severe COVID-19

Researchers suggest that low anti-spike IgG1 glycosylation, sialyation, and high bisection are markers of severe COVID-19.

24 Mar 2022

New approach could lead to quicker generation of effective, personalized cancer vaccines

Scientists have created a pipeline for identifying, prioritizing and evaluating potential tumor antigens for the fast generation of cancer vaccines, according to a report published today in eLife.

22 Mar 2022

Influence of vitamin D and age on first SARS-CoV-2 vaccine dose efficacy

Researchers illustrated that vitamin D status and age influence antibody response following the initial dose of coronavirus disease 2019 vaccination.

21 Mar 2022

Antimicrobial resistance in COVID-19

Researchers discuss the impact of this extensive use of antibiotics on the rise of antimicrobial resistance.

16 Mar 2022

Acacetin shows potency against SARS-CoV-2 spike protein

Researchers use molecular docking to screen phytocompounds and evaluate their binding affinity with SARS-CoV-2.

15 Mar 2022

Detailed molecular map of stratum corneum can help develop new skin treatments

Scientists have accurately analyzed the tough barrier layer of the skin giving the most detailed molecular map of its structure that will help in the development of new skin products and treatments.

14 Mar 2022

UNC researchers offer solution to detect, issue warnings about tainted street drugs

With new grant funding, Nabarun Dasgupta '13 (Ph.D.), Gillings Innovation Fellow at the UNC-Chapel Hill Gillings School of Global Public Health and senior scientist at the UNC Injury Prevention Research Center, will work with colleagues across Carolina to develop systems to detect and issue public warnings about dangerous adulterants in street drugs.

14 Mar 2022

Researchers find unusual way of stabilizing cancer-suppressing protein

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers at Karolinska Institutet in Sweden have now found an unusual way of stabilizing the protein and making it more potent.

14 Mar 2022

Merck and Waters to Collaborate on Extractables and Leachables Reference Library

Merck, a leading science and technology company, today announced that its Life Science business sector has entered into a collaboration with Waters Corporation to build and expand an Extractables and Leachables (E&L) Reference Library to include ion mobility measurements.

From Merck 11 Mar 2022

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Researchers discovered and optimized cysteine-reactive pyrazoline-based covalent inhibitors for several coronaviruses' Mpro, including SARS-CoV-2.

11 Mar 2022

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

A new study used glycoprotein profiling technology platform that couples high-resolution LC-MS for glycoprotein analysis in regards to COVID-19.

9 Mar 2022

Lower exosome component 2 expression protects against clinical SARS-CoV-2 infection

In a recent study posted to the bioRxiv* preprint server, researchers demonstrated that the lower expression of EXOSC2 human protein safeguards from clinical coronavirus disease 2019 (COVID-19). This protective effect was via the reduced EXOSC2 expression-associated suppression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication.

9 Mar 2022

New analysis method to identify interacting proteins in a protein degrader-dependent manner

Protein degraders, which induce the protein degradation of target proteins, are expected to be the "next-generation drugs" because they can remove disease-related proteins from cells.

8 Mar 2022

Study reveals the potential of novel antiviral drug combinations to stop COVID-19 spread

Researchers from Columbia Engineering, Fiocruz's Center for Technological Development in Health and the Oswaldo Cruz Institute in Brazil, Memorial Sloan Kettering Cancer Center, and Rockefeller University recently reported that, by combining inhibitors of polymerases and exonucleases--enzymes that allow SARS-CoV-2 to reproduce--they were able to reduce SARS-CoV-2 replication 10 times more than when using just the polymerase inhibitors.

7 Mar 2022

Manipulating carotenoids can improve plant growth, stress tolerance and increase yield

Manipulating the content of carotenoids, such as ß-carotene, has been found to improve plant growth and increase yield and tolerance to abiotic stresses such as drought and salinity.

7 Mar 2022

Aldosterone levels undetectably low in hospitalized COVID-19 patients

A new study reports finds very low aldosterone levels in a subset of COVID-19 patients.

6 Mar 2022

Gas chromatography-ion mobility spectrometry helps diagnose COVID-19 and predict disease severity

Researchers assess the ability of GC-IMS to differentiate between COVID-19 and other respiratory infections, as well as predict disease severity.

4 Mar 2022

Lipidomic profiling may provide early prediction of type 2 diabetes and cardiovascular disease risk

Simultaneous measurement of dozens of types of fats in the blood ("lipidomics") can predict the risk of developing type 2 diabetes (T2D) and cardiovascular disease (CVD) years in the future, according to a new study publishing March 3rd in the open-access journal PLOS Biology from Chris Lauber of Lipotype, Germany, and colleagues.

3 Mar 2022

Using oral blood pressure drug to treat Type 1 diabetes shows benefits for at least two years

Use of the drug verapamil to treat Type 1 diabetes continues to show benefits lasting at least two years, researchers report in the journal Nature Communications.

3 Mar 2022

Spectrometry News and Research

A summary of SARS-CoV-2 RNA-protein interactome studies

IgG Fc glycosylation: A marker for severe COVID-19

New approach could lead to quicker generation of effective, personalized cancer vaccines

Influence of vitamin D and age on first SARS-CoV-2 vaccine dose efficacy

Antimicrobial resistance in COVID-19

Acacetin shows potency against SARS-CoV-2 spike protein

Detailed molecular map of stratum corneum can help develop new skin treatments

UNC researchers offer solution to detect, issue warnings about tainted street drugs

Researchers find unusual way of stabilizing cancer-suppressing protein

Merck and Waters to Collaborate on Extractables and Leachables Reference Library

Further optimization of cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

Lower exosome component 2 expression protects against clinical SARS-CoV-2 infection

New analysis method to identify interacting proteins in a protein degrader-dependent manner

Study reveals the potential of novel antiviral drug combinations to stop COVID-19 spread

Manipulating carotenoids can improve plant growth, stress tolerance and increase yield

Aldosterone levels undetectably low in hospitalized COVID-19 patients

Gas chromatography-ion mobility spectrometry helps diagnose COVID-19 and predict disease severity

Lipidomic profiling may provide early prediction of type 2 diabetes and cardiovascular disease risk

Using oral blood pressure drug to treat Type 1 diabetes shows benefits for at least two years

Enhancing confidence in chemical ionization spectrometry data eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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