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Researchers explore how blocking EGFR changes signaling in glioblastoma cells

Proteins that control cell growth are often mutated in cancer, and their aberrant signaling drives the wild proliferation of cells that gives rise to tumors. One such protein, the epidermal growth factor receptor, fuels a wide variety of cancers-including a highly malignant brain cancer known as glioblastoma.

9 Apr 2013

Research findings could help develop effective vaccines against new strains of bird flu

Scientists have described small genetic changes that enable the H5N1 bird flu virus to replicate more easily in the noses of mammals.

9 Apr 2013

American Cancer Society announces new research, training grants for fiscal year 2013

The American Cancer Society, the largest non-government, not-for-profit funding source of cancer research in the United States, has awarded 175 national research and training grants totaling $79,073,250 for fiscal year 2013.

9 Apr 2013

ARIAD Pharmaceuticals presents preclinical data on ponatinib at AACR Annual Meeting 2013

ARIAD Pharmaceuticals, Inc. today announced the presentation of preclinical data on ponatinib (Iclusig) , at the American Association for Cancer Research Annual Meeting 2013, in Washington.

9 Apr 2013

WHO considers sending experts to China as death toll from H7N9 virus hits 7

The WHO "is talking with the Chinese government about sending international experts to China to help investigate a new bird flu strain that has sickened at least 24 people, killing seven of them," the Associated Press reports.

9 Apr 2013

Certain brain tumors develop drug resistance by exploiting normal cellular signaling pathways

Proteins that control cell growth are often mutated in cancer, and their aberrant signaling drives the wild proliferation of cells that gives rise to tumors.

9 Apr 2013

Johns Hopkins researchers find how gout-linked genetic mutation contributes to disease

Johns Hopkins scientists have found out how a gout-linked genetic mutation contributes to the disease: by causing a breakdown in a cellular pump that clears an acidic waste product from the bloodstream.

9 Apr 2013

Researchers discover that fruit fly mutation holds clues for treating motor neuron diseases

A team of researchers, led by Marc Freeman, PhD, an early career scientist with the Howard Hughes Medical Institute and associate professor of neurobiology at the University of Massachusetts Medical School have discovered a gene in the fruit fly Drosophila melanogaster that, when mutant, blocks the self-destruction of damaged axons, which could hold clues to treating motor neuron diseases, such as amyotrophic lateral sclerosis.

9 Apr 2013

MIT researchers present novel approach to develop dengue therapy using mutated antibodies

Nearly half of the world's population is at risk of infection by the dengue virus, yet there is no specific treatment for the disease. Now a therapy to protect people from the virus could finally be a step closer, thanks to a team at MIT.

9 Apr 2013

Research sheds new light on role of ATRX mutations in brain and pituitary

Research from Western University and Lawson Health Research Institute sheds new light on a gene called ATRX and its function in the brain and pituitary.

9 Apr 2013

New drug combination shows anti-cancer activity in patients with solid tumors and germline mutation

A novel combination of two drugs has shown anti-cancer activity in patients who had incurable solid tumors and carried a germline mutation in their BRCA genes, Dana-Farber Cancer Institute researchers are reporting at the American Association for Cancer Research annual meeting in Washington, April 6-10.

8 Apr 2013

Researchers identify four genes newly associated with severe childhood obesity

Researchers have identified four genes newly associated with severe childhood obesity. They also found an increased burden of rare structural variations in severely obese children.

8 Apr 2013

GE Healthcare releases next-generation sequencing assay for use in clinical trials

GE Healthcare announced today that Clarient Diagnostic Services, Inc., a GE Healthcare company, will begin offering a next-generation sequencing assay focused on solid tumor targets for use in clinical trials.

8 Apr 2013

Blood test reveals more gene mutations in cancer than traditional tumor biopsy

A new blood test revealed more of the gene mutations that sustain certain digestive-tract tumors than did a DNA analysis of a traditional tumor biopsy, Dana-Farber Cancer Institute investigators will report at a special symposium of the American Association for Cancer Research annual meeting in Washington, April 6-10.

8 Apr 2013

Physician-researcher to lead pediatric Dream Team to create new treatments for childhood cancers

A physician-researcher from The Children's Hospital of Philadelphia will lead the first-ever pediatric "Dream Team" solely focused on creating new treatments for the most challenging childhood cancers.

8 Apr 2013

Research identifies important role of zinc in kidney stone formation

Kidney stones usually make their presence known suddenly, often sending a person to the hospital in excruciating pain. Each year in the U.S. more than a million people seek medical attention for kidney stones, technically called nephrolithiasis.

8 Apr 2013

Fruit fly study offers clues to wound healing

A person's skin and a fruit fly's exoskeleton, called a "cuticle" may not look alike, but both coverings protect against injury, infection, and dehydration.

6 Apr 2013

Individualized genomic analysis allows for tailored cancer treatment, new drug research

Just like a massive iceberg jutting out of the ocean, many of cancer's genetic underpinnings remain hidden under the surface, impossible to predict or map from above.

6 Apr 2013

Researchers map immune response to HIV, say findings could inform vaccine science

In research that could help in the search for an HIV vaccine, "American researchers have minutely tracked one person's powerful immune response to the virus to see how a series of mutations led to an antibody that can defeat many HIV strains," the New York Times reports (McNeil, 4/3).

5 Apr 2013

China reports 2 more cases of H7N9; Researchers continue to investigate transmission routes

"China has found two more cases of a new strain of bird flu and one of the victims has died, state media said on Wednesday, bringing to nine the number of confirmed human infections from the previously unknown flu type," Reuters reports (Blanchard/Kelland, 4/3).

5 Apr 2013

Mutation News and Research

Researchers explore how blocking EGFR changes signaling in glioblastoma cells

Research findings could help develop effective vaccines against new strains of bird flu

American Cancer Society announces new research, training grants for fiscal year 2013

ARIAD Pharmaceuticals presents preclinical data on ponatinib at AACR Annual Meeting 2013

WHO considers sending experts to China as death toll from H7N9 virus hits 7

Certain brain tumors develop drug resistance by exploiting normal cellular signaling pathways

Johns Hopkins researchers find how gout-linked genetic mutation contributes to disease

Researchers discover that fruit fly mutation holds clues for treating motor neuron diseases

MIT researchers present novel approach to develop dengue therapy using mutated antibodies

Research sheds new light on role of ATRX mutations in brain and pituitary

New drug combination shows anti-cancer activity in patients with solid tumors and germline mutation

Researchers identify four genes newly associated with severe childhood obesity

GE Healthcare releases next-generation sequencing assay for use in clinical trials

Blood test reveals more gene mutations in cancer than traditional tumor biopsy

Physician-researcher to lead pediatric Dream Team to create new treatments for childhood cancers

Research identifies important role of zinc in kidney stone formation

Fruit fly study offers clues to wound healing

Individualized genomic analysis allows for tailored cancer treatment, new drug research

Researchers map immune response to HIV, say findings could inform vaccine science

China reports 2 more cases of H7N9; Researchers continue to investigate transmission routes

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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