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Microgravity culture during spaceflight enhances microbial infection process in 3D intestinal models

Infectious microbes have evolved sophisticated means to invade host cells, outwit the body's defenses and cause disease.

1 Jun 2022

Inhibiting immune response-related enzyme holds promise in preventing or treating severe COVID-19

Blocking an immune response-related enzyme holds promise in preventing or treating severe COVID-19 symptoms by reducing inflammation, tissue injury and blood clots in the lungs, new research in mice suggests.

1 Jun 2022

Study finds a link between aging and cancer metastases

Spreading cancer cells that escape a primary tumor site can seed in tissues distant from the tumor, but may take several years or decades to grow into full metastatic cancers.

1 Jun 2022

Researchers identify chemical compound that may short-circuit brain cell death in Parkinson's disease

In studies in mice, Johns Hopkins Medicine researchers say they have identified a chemical compound that stops the final events in the pathway linked to the death of brain cells in Parkinson's disease.

1 Jun 2022

People with food allergies less likely to become infected with SARS-CoV-2, study finds

A National Institutes of Health-funded study has found that people with food allergies are less likely to become infected with SARS-CoV-2, the virus that causes COVID-19, than people without them. In addition, while previous research identified obesity as a risk factor for severe COVID-19, the new study has identified obesity and high body mass index (BMI) as associated with increased risk for SARS-CoV-2 infection.

1 Jun 2022

SARS-CoV-2 variant emergence patterns across Alaska

A new study preprint server assesses the pattern of SARS-CoV-2 variant emergence across Alaska.

1 Jun 2022

Tracking the emergence of potential drug-resistant mutations in SARS-CoV-2 proteins

Researchers hypothesized that the emergence of resistant SARS-CoV-2 variants can be anticipated by identifying possible escape mutations already present in the existing SARS-CoV-2 populations.

1 Jun 2022

Structural and biochemical traits of main protease-mediated SARS-CoV-2 polyprotein processing

A recent article illustrated the structural and biochemical characteristics of the processing of SARS-CoV-2 polyproteins by Mpro.

1 Jun 2022

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

Researchers identified a single viral gene product, the accessory factor ORF7a, facilitating SARS-CoV-2 immune evasion by downregulating the surface expression of MHC class I molecules.

1 Jun 2022

UCLA researchers identify a method to make tumors susceptible to immune attack

One powerful way cancer cells defend against tumor-killing immune cells is to load up their cell surface with a protein known as PD-L1. Now a team of UCLA Jonsson Comprehensive Cancer Center researchers led by Roger S. Lo, MD, PhD, has identified a method to degrade tumor cell-surface PD-L1, thereby making tumors susceptible to immune attack.

31 May 2022

Study highlights the positive effects of Humanin G in reducing inflammation in AMD

A new research paper was published in Aging (Aging-US) on the cover of Volume 14, Issue 10, entitled, "Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD)."

31 May 2022

Researchers discover how a workhorse protein keeps protein production on track

Cells produce proteins like little factories. But if they make too much at the wrong times it can lead to diseases like cancer, so they control production with a process called RNA interference (RNAi).

31 May 2022

Study analyzes how four types of COVID-19 vaccines prepare the body to fight SARS-CoV-2

Scientists at La Jolla Institute for Immunology have published the first analysis of how four types of COVID-19 vaccines prepare the body to fight SARS-CoV-2.

31 May 2022

Scientists develop new way to attack synovial sarcoma using an investigational drug

Researchers at Washington University School of Medicine in St. Louis have developed a way to attack synovial sarcoma - a rare tumor of soft tissues, such as ligaments and muscles - using an investigational drug that triggers cell death.

31 May 2022

Scientists discover a new role for protein complex at the center of Bardet-Biedl syndrome

Scientists have identified a new role for a protein complex at the center of a human genetic disorder called Bardet-Biedl syndrome, or BBS, for which there is currently no cure.

31 May 2022

The pineapple-derived jacalin-related lectin as a potential anti-SARS-CoV-2 agent

Scientists demonstrated that the pineapple-derived jacalin-related lectin (AcmJRL/AnLec) could be an anti-SARS-CoV-2 agent.

31 May 2022

The immunogenicity and safety of the adjuvanted recombinant protein vaccine Sanofi/GSK-D614 or -B.1.351 administered as a heterologous booster dose

Researchers assessed the safety and immunogenicity of SARS-CoV-2 booster vaccines.

31 May 2022

New compounds for cancer immunotherapy via STING-mediated immune activation

Innovations in cancer immunotherapy have achieved clinical success by considerably increasing the survival rate of patients undergoing cancer treatment.

31 May 2022

Vitamin D therapy may be a useful addition to the treatment of ovarian cancer, study suggests

Ovarian cancer has one of the highest death rates of all cancers. One reason for this is that cancer turns the body's defenses against itself. However, new research from Nagoya University published in Matrix Biology suggests that vitamin D can effectively prevent one of the key pathways used by this cancer.

30 May 2022

Evaluating tixagevimab plus cilgavimab against SARS-CoV-2

Researchers assessed the neutralizing activity against SARS-CoV-2 Omicron variant after tixagevimab plus cilgavimab (T+C) administration.

30 May 2022

Protein C News and Research

Microgravity culture during spaceflight enhances microbial infection process in 3D intestinal models

Inhibiting immune response-related enzyme holds promise in preventing or treating severe COVID-19

Study finds a link between aging and cancer metastases

Researchers identify chemical compound that may short-circuit brain cell death in Parkinson's disease

People with food allergies less likely to become infected with SARS-CoV-2, study finds

SARS-CoV-2 variant emergence patterns across Alaska

Tracking the emergence of potential drug-resistant mutations in SARS-CoV-2 proteins

Structural and biochemical traits of main protease-mediated SARS-CoV-2 polyprotein processing

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

UCLA researchers identify a method to make tumors susceptible to immune attack

Study highlights the positive effects of Humanin G in reducing inflammation in AMD

Researchers discover how a workhorse protein keeps protein production on track

Study analyzes how four types of COVID-19 vaccines prepare the body to fight SARS-CoV-2

Scientists develop new way to attack synovial sarcoma using an investigational drug

Scientists discover a new role for protein complex at the center of Bardet-Biedl syndrome

The pineapple-derived jacalin-related lectin as a potential anti-SARS-CoV-2 agent

The immunogenicity and safety of the adjuvanted recombinant protein vaccine Sanofi/GSK-D614 or -B.1.351 administered as a heterologous booster dose

New compounds for cancer immunotherapy via STING-mediated immune activation

Vitamin D therapy may be a useful addition to the treatment of ovarian cancer, study suggests

Evaluating tixagevimab plus cilgavimab against SARS-CoV-2

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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