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First evidence of the molecular link between inflammation and cancer

The investigators found that a gene called I-kappa-B kinase (IKK beta), a pro-inflammatory gene, acts differently in two cell types to cause cancer. When IKK beta was deleted, the cancer incidence and tumor growth in mice was decreased by nearly 80 percent.

5 Aug 2004

Approval of cholesterol-lowering therapy Lipitor for the prevention of cardiovascular disease

Pfizer has announced that the U.S. Food and Drug Administration has approved its cholesterol-lowering therapy Lipitor® (atorvastatin calcium) for the prevention of cardiovascular disease by reducing heart attack risk in people with normal to mildly elevated cholesterol levels who have other cardiovascular risk factors.

5 Aug 2004

Entirely new approach to the treatment of aging

Dispelling the belief that the only way to treat such conditions is by fixing or replacing damaged genes, they instead focused on the field of epigenetics—the study of changes in gene silencing that occur without changes in the genes themselves.

3 Aug 2004

Metabasis Therapeutics announces multi-center Phase 2 study to evaluate the orally administered antiviral compound remofovir mesylate

Metabasis Therapeutics has announced the initiation of a multi-center, multi- national Phase 2 study to evaluate the orally administered antiviral compound remofovir mesylate in chronic hepatitis B (HBV) infected patients.

3 Aug 2004

Drug to fight virus from the herpes family in transplant patients moves forward in trials

A drug once considered for cancer chemotherapy is advancing in clinical trials to test its effectiveness in fighting a virus from the herpes family that threatens transplant patients.

29 Jul 2004

Adenosine triphosphate is a culprit in causing the devastating damage of spinal cord injury

ATP - adenosine triphosphate, the vital energy source that keeps our body’s cells alive, runs amok at the site of a spinal cord injury, pouring into the area around the wound and killing the cells that normally allow us to move, scientists report in the cover story of the August issue of Nature Medicine.

29 Jul 2004

Proof of principle that it is possible to deliver new genes body-wide to all the muscles of an adult animal

MDA-supported researchers at the University of Washington-Seattle have delivered the gene for the dystrophin protein to all voluntary muscles with a single intravenous injection in mice with Duchenne muscular dystrophy (DMD).

29 Jul 2004

Patent pending botanical extract, V38-AMF-1, completely inhibits bird flu (H5N1) and Fujian Flu

PRB Pharmaceuticals and Lee's Pharmaceuticals have announced the discovery that PRB'S patent pending botanical extract, V38-AMF-1, completely inhibits bird flu (H5N1) and Fujian Flu (H3N2) infections in vitro.

29 Jul 2004

Several key findings from clinical trial of an investigational Alzheimer's disease treatment

Elan Corporation and Wyeth Pharmaceuticals have announced several key findings from their Phase IIa clinical trial of an investigational Alzheimer's disease (AD) treatment, AN-1792, which were presented in Philadelphia at the 9th International Conference on Alzheimer's Disease and Related Disorders.

22 Jul 2004

Natural organohalogens have potent anticancer and antibacterial activity

Human made chemical compounds called organohalogens get loads of attention as they are best known for their often harmful effect on the environment - substances like the CFCs (the ozone-damaging chemicals), dioxin (found in the herbicide Agent Orange), PCBs (industrial fluids) and several pesticides.

22 Jul 2004

Neuro3d identifies candidate compound

The identification of this compound and extension of the research collaboration by J&JPRD further highlights the strength of Neuro3d's internal drug discovery capabilities.

21 Jul 2004

Cinnamon oil may be an environmentally friendly pesticide, with the ability to kill mosquito larvae

A new study published in the Journal of Agricultural and Food Chemistry, shows that cinnamon oil may be an environmentally friendly pesticide, with the ability to kill mosquito larvae.

19 Jul 2004

New compound that is designed to overcome Gleevec resistance

One of the truly spectacular success stories in modern oncology is the development and implementation of Gleevec, a drug that virtually halts the progress of chronic myeloid leukemia. Yet for some patients who harbor particularly stubborn genetic mutations, Gleevec fails miserably.

17 Jul 2004

Docosahexaenoic acid levels play an important role in infant development

Docosahexaenoic acid, or "DHA," is a nutritional compound (an essential fatty acid, or lipid) that has many effects in the body, including the development of the eyes and brain.

16 Jul 2004

New SARS air filter

Matsushita (Panasonic) has announced its environment-related subsidiary, Matsushita Ecology Systems Co., Ltd., has developed a revolutionary SARS air filter.

15 Jul 2004

Latest findings on HIV pathogenesis at AIDS Conference in Bangkok

At the XVth International AIDS Conference in Bangkok, Thailand, Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases and chief of the NIAID Laboratory of Immunoregulation (LIR), will present his laboratory’s latest findings on how aberrant immune activation underlies HIV pathogenesis.

15 Jul 2004

Natural products to be developed as anti-cancer therapeutics

The licence grants Zentaris exclusive worldwide rights for the development, manufacture and marketing of disorazoles, a novel class of natural products with strong anti-cancer potential discovered by GBF researchers.

8 Jul 2004

Genes linked to cardiovascular disease more common among African Americans than those of European descent

Three gene variants that have been associated with heart attack risk in Japanese studies occur more frequently among African Americans than those of European descent

7 Jul 2004

New compound, ZK-CDK combines the inhibition of tumour cell growth as well as inhibition of tumour angiogenesis in one single molecule

Treatment with a new dual cell cycle and angiogenesis pathway inhibitor blocks VEGF-induced vascular permeability, inhibits tumour angiogenesis and induces apoptosis in human tumour models

7 Jul 2004

High levels of endotoxin, a bacterial compound that collects in house dust, may lower likelihood of eczema in children

Children whose homes contain high levels of endotoxin, a bacterial compound that collects in house dust, may be less likely to develop eczema during their first year of life

6 Jul 2004

Compound News and Research

First evidence of the molecular link between inflammation and cancer

Approval of cholesterol-lowering therapy Lipitor for the prevention of cardiovascular disease

Entirely new approach to the treatment of aging

Metabasis Therapeutics announces multi-center Phase 2 study to evaluate the orally administered antiviral compound remofovir mesylate

Drug to fight virus from the herpes family in transplant patients moves forward in trials

Adenosine triphosphate is a culprit in causing the devastating damage of spinal cord injury

Proof of principle that it is possible to deliver new genes body-wide to all the muscles of an adult animal

Patent pending botanical extract, V38-AMF-1, completely inhibits bird flu (H5N1) and Fujian Flu

Several key findings from clinical trial of an investigational Alzheimer's disease treatment

Natural organohalogens have potent anticancer and antibacterial activity

Neuro3d identifies candidate compound

Cinnamon oil may be an environmentally friendly pesticide, with the ability to kill mosquito larvae

New compound that is designed to overcome Gleevec resistance

Docosahexaenoic acid levels play an important role in infant development

New SARS air filter

Latest findings on HIV pathogenesis at AIDS Conference in Bangkok

Natural products to be developed as anti-cancer therapeutics

Genes linked to cardiovascular disease more common among African Americans than those of European descent

New compound, ZK-CDK combines the inhibition of tumour cell growth as well as inhibition of tumour angiogenesis in one single molecule

High levels of endotoxin, a bacterial compound that collects in house dust, may lower likelihood of eczema in children

Advancing therapeutic biopolymer development eBook

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

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