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Investigational topical cream may be effective for treating atopic dermatitis

A study published in the British Journal of Dermatology indicates that an investigational nonsteroidal topical cream may be effective for treating atopic dermatitis, one of the most common inflammatory skin diseases.

9 Jan 2019

Metabolite from berries and pomegranates can mitigate inflammatory bowel disease

Millions of people suffer from inflammatory bowel disease worldwide, either in the form of ulcerative colitis or Crohn's disease, and few effective long-term treatments are available. Chronic intestinal inflammation is a hallmark of IBD.

9 Jan 2019

Study shows how specific mutations in SYNE1 gene may increase bipolar disorder risk

A new study by researchers at The Picower Institute for Learning and Memory at MIT finds that the protein CPG2 is significantly less abundant in the brains of people with bipolar disorder and shows how specific mutations in the SYNE1 gene that encodes the protein undermine its expression and its function in neurons.

9 Jan 2019

New analytic method can precisely detect viral infections using immune responses

Cytomegalovirus is widespread and remains in the body for a lifetime after infection. In healthy individuals, this virus is usually kept in check but can become dangerous when the immune system is weakened or during pregnancy.

8 Jan 2019

Therapeutic implications of caffeine in neuropsychiatric disorders

An important new article reviews recently discovered properties of adenosine A2A receptor-dopamine D2 receptor and adenosine A1 receptor-dopamine D1 receptor heteromers--both of which are main targets for caffeine--and discusses the therapeutic implications of these findings.

7 Jan 2019

Cellular protein signal can be manipulated to favor bone building

In experiments in rats and human cells, Johns Hopkins Medicine researchers say they have added to evidence that a cellular protein signal that drives both bone and fat formation in selected stem cells can be manipulated to favor bone building.

7 Jan 2019

Faulty immune receptor in HIV patients could be reason why many experience complications

For HIV patients, treatments that control the infection have come a long way. But many still struggle with a host of other disease-related complications such as neurocognitive disorders, cardiovascular issues, diabetes and chronic inflammation.

7 Jan 2019

Scientists identify new bat-borne virus related to Ebola

Researchers from Singapore's Duke-NUS Medical School, in collaboration with scientists in China, have identified and characterized a new genus of filovirus from a Rousettus bat in China. Their findings were published in the journal Nature Microbiology.

7 Jan 2019

First viable mouse model of Hirschsprung's disease developed

About one in every 5,000 babies is born without enteric neurons in distal colon resulting in Hirschsprung's disease. Because of the lacking neurons, contents of the gut cannot pass normally resulting in constipation and enlargement of colon.

7 Jan 2019

A small protein plays key role in how cancer stem cells differentiate

A jagged little protein appears to be key to how cancer stem cells differentiate and enable metastasis, according to researchers at Rice University and the Duke University School of Medicine.

4 Jan 2019

Researchers shed new light on the body's largest cell receptor

A giant toadstool that swallow up vitamins and nutrients. This is how the receptor, which e.g. absorbs B12 vitamin, looks. For the first time, researchers have an insight into a biology which has survived millions of years.

3 Jan 2019

Researchers develop new method of analysis to map cellular locations of proteins

Researchers at Karolinska Institutet and SciLifeLab have developed a new method of analysis that maps the location of proteins in the cell. The information has been compiled in a database that is accessible to researchers around the world.

3 Jan 2019

New medications provide better treatment for alcohol use disorders, chronic pain, mood disorders

Helping people with addictions has become a research passion for Purdue University's Richard van Rijn, who is leading a team to make drug discoveries to support millions around the world dealing with alcohol use disorders, chronic pain and mood disorders.

3 Jan 2019

Study follows children into adolescence to more accurately assess type 1 diabetes risk

Scientists are narrowing in on checklists of both errant genes and the environmental factors that could trigger those genes to more accurately assess type 1 diabetes risk and help children and their families avoid it.

3 Jan 2019

Scientists cast new light on function of long-mysterious PCSK9 mutation

High levels of low-density lipoproteins, parcels of lipids and protein that carry cholesterol, are a leading risk factor for heart disease. Many cholesterol medications lower LDL, some of them by targeting the protein PCSK9. In the January issue of the Journal of Lipid Research, scientists at the University of California, San Francisco, report on an investigation into why experiments on PCSK9 give different results in a test tube and in liver cells.

2 Jan 2019

Study provides new insights into how genes are activated

In a study in Nature, researchers at Karolinska Institutet present a new method for analyzing how instructions in the genome control how our genes are activated in individual cells.

2 Jan 2019

Rockefeller scientists uncover genetic mutation responsible for tuberculosis vulnerability

If you live in the United States, you are unlikely to come into contact with the microbe that causes tuberculosis. Your odds of encountering the microbe are so low, in fact, that risk factors for the disease can easily go unnoticed: If you happened to carry a gene that predisposed you to tuberculosis, you likely wouldn't know.

2 Jan 2019

Using Assay Kits and Dyes to Advance Cell Biology Research

In this interview, Richard Delle Bovi highlights live cell ability of the CELLESTIAL® analysis kit from Enzo Life Sciences and its applications in cell biology.

From Enzo Life Sciences, Inc. 2 Jan 2019

Research reviews role of protein tyrosine phosphatase in molecular biology

As the proteomics technology develops and human genomic analysis becomes easier to execute, molecules involved in the regulation of biochemical signaling pathways have become interesting subjects for researchers.

28 Dec 2018

MUSC researchers link higher levels of AGEs to ER-positive breast cancer risk

Poor diet and lack of exercise are associated with cancer development, but the underlying biology is not well understood. Advanced glycation end products could offer a biological link to help us understand how certain lifestyle behaviors increase cancer risk or lessen the likelihood that an anti-cancer therapy will be effective.

28 Dec 2018

Receptor News and Research

Investigational topical cream may be effective for treating atopic dermatitis

Metabolite from berries and pomegranates can mitigate inflammatory bowel disease

Study shows how specific mutations in SYNE1 gene may increase bipolar disorder risk

New analytic method can precisely detect viral infections using immune responses

Therapeutic implications of caffeine in neuropsychiatric disorders

Cellular protein signal can be manipulated to favor bone building

Faulty immune receptor in HIV patients could be reason why many experience complications

Scientists identify new bat-borne virus related to Ebola

First viable mouse model of Hirschsprung's disease developed

A small protein plays key role in how cancer stem cells differentiate

Researchers shed new light on the body's largest cell receptor

Researchers develop new method of analysis to map cellular locations of proteins

New medications provide better treatment for alcohol use disorders, chronic pain, mood disorders

Study follows children into adolescence to more accurately assess type 1 diabetes risk

Scientists cast new light on function of long-mysterious PCSK9 mutation

Study provides new insights into how genes are activated

Rockefeller scientists uncover genetic mutation responsible for tuberculosis vulnerability

Using Assay Kits and Dyes to Advance Cell Biology Research

Research reviews role of protein tyrosine phosphatase in molecular biology

MUSC researchers link higher levels of AGEs to ER-positive breast cancer risk

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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