Tumor News and Research

RSS

Truncal mutations study suggests new direction in origins of cancer

Cancers most commonly arise because of a series of two to five mutations in different genes that combine to cause a tumor.

16 Jan 2019

Research reveals novel approach to suppressing chemotherapy-induced tumor growth

Following up on a groundbreaking 2018 study in which BIDMC's Dipak Panigrahy, MD, demonstrated that dead and dying cancer cells killed by conventional cancer treatments paradoxically trigger inflammation that promotes tumor growth and metastasis, a new study led by Allison Gartung, PhD, describes a novel approach to suppressing chemotherapy-induced tumor growth in an ovarian cancer model.

16 Jan 2019

TGF-beta signaling pathway in uterine cells protects against cancer

Two new mouse models of uterine cancer shed light on how this disease - the most common gynecological cancer in the U.S. - happens.

16 Jan 2019

Hypertension drug may improve effectiveness of ovarian cancer treatment

A new study from a Massachusetts General Hospital research team has found that the hypertension drug losartan, which targets the angiotensin signaling pathway, may improve the effectiveness of chemotherapy agents used to treat ovarian cancer

16 Jan 2019

MD Anderson Cancer Center collaborates with Dragonfly for new immunotherapy drug clinical trials

The University of Texas MD Anderson Cancer Center and Dragonfly Therapeutics, Inc., today announced a strategic collaboration to bring Dragonfly's TriNKET™ immunotherapy drug candidates to patients in clinical trials beginning in 2019.

16 Jan 2019

FDA-approved drug hampers cancer metastasis in animal model, shows study

For cancer to spread, it needs a hospitable environment in distant organs. This fertile "soil" can provide a home to circulating malignant cells.

16 Jan 2019

New evidence shows how fever alters immune cells

Fever is known to help power up our immune cells, and scientists in Shanghai have new evidence explaining how.

16 Jan 2019

Researchers identify a key regulator that stops excessive inflammation

A component has been identified by researchers in Umeå as a novel regulator of the immune system. It acts as a molecular switch to deactivate the innate immune system and has the ability to prevent certain diseases caused by an excessive activation of the immune system.

15 Jan 2019

Synthetic compound reverses mutant p53 aggregate accumulation, study shows

Cancer is a multidisciplinary disease, with different mutations leading to different prognoses and treatment necessities. Among the most important mutation targets in cancers, affecting more than 50% of all cancer cases, is TP53.

14 Jan 2019

Study shows how herpes viruses and tumors have learned to manipulate the same ancient RNA

Herpes viral infections use the ancient genetic material found in the human genome to proliferate, mimicking the same process tumors have been found to manipulate, Mount Sinai researchers have shown for the first time.

14 Jan 2019

Molecular hallmarks of tumor hypoxia across 19 cancer types discovered

Unlike healthy tissues, tumors thrive in low-oxygen environments, often acquiring the ability to resist treatment and spread to other sites in the body. Despite being a well-known cause of therapy resistance and metastasis, the impact of low oxygen, known as hypoxia, on tumor cells is poorly understood.

14 Jan 2019

Turning breast cancer cells into fat cells prevents the formation of metastases

An innovative combination therapy can force malignant breast cancer cells to turn into fat cells. This can be used to prevent the formation of metastases in mice, as researchers at the University of Basel's Department of Biomedicine recently reported in the journal Cancer Cell.

14 Jan 2019

Identifying genetic factors that lead to squamous cell carcinoma

Skin cancer is on the rise in the United States. Squamous cell carcinoma, the second most common form of cancer in the U.S., has the highest mortality rate of all non-melanoma skin cancers. In roughly two to five percent of patients, the disease will metastasize and spread throughout the body, making it difficult to treat.

14 Jan 2019

Scientists discover mutational signatures of tumor hypoxia

Researchers have discovered mutational signatures of tumor hypoxia in 19 cancer types that could be used to identify patients who need higher treatment doses.

14 Jan 2019

Scientists find link between colitis and colon cancer

Lingering inflammation in the colon is a known risk factor for colorectal cancer and now scientists report one way it resets the stage to enable this common and often deadly cancer.

14 Jan 2019

New potential immunotherapy target in pancreatic cancer identified

Researchers have identified a new potential immunotherapy target in pancreatic cancer, which so far has been notoriously resistant to treatment with immune checkpoint blockade drugs effective against a variety of other cancers.

11 Jan 2019

New research could have a significant impact on cancer therapy

Research led by Suresh Alahari, PhD, the Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health New Orleans School of Medicine, has found a new role for a protein discovered by his lab in preventing the growth and spread of breast cancer.

11 Jan 2019