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UC San Francisco scientists identify 'Achilles heel' of drug-resistant cancers

UC San Francisco scientists have figured out why some lung cancers become drug-resistant after initially responding to targeted therapies.

27 Nov 2018

Researchers identify multisystem disorder caused by bi-allelic variants in CCDC47 gene

Researchers and clinicians through a multicenter collaboration have identified a novel multisystem disorder caused by bi-allelic variants in the CCDC47 gene. Their findings are reported in the American Journal of Human Genetics.

20 Nov 2018

Towards finding a druggable cancer target

It's known that cancer involves unchecked cell growth and that a biological pathway that regulates organ size, known at the Hippo pathway, is also involved in cancer.

19 Nov 2018

Surprising discovery about BH4 may rekindle interest in once-promising pathway

In 2013, renowned Boston Children's Hospital pain researcher Clifford Woolf, MB, BCh, PhD, and chemist Kai Johnsson, PhD, his fellow co-founder at Quartet Medicine, believed they held the key to non-narcotic pain relief.

19 Nov 2018

CRISPR-based tool shown to enhance cell-based immunotherapy

Researchers have developed a CRISPR-based tool called SLICE that can boost the effectiveness of immune cell therapies.

15 Nov 2018

Two genomic tests help identify most effective treatment for breast cancer patients

New results from a long-running trial to identify which new drugs or combinations of drugs are most effective in which types of breast cancer, show that two genomic tests are bringing the era of truly personalized medicine ever nearer.

14 Nov 2018

Study defines biomarker in response to treatment of castration-resistant prostate cancer

The most aggressive type of prostate cancer, castration-resistant prostate cancer, can be treated with two different therapies: taxanes or hormone treatment. Until this day there are no comparative studies between the two and the decision on which treatment to use is done empirically and based on the patient's preferences.

14 Nov 2018

Dietary restriction could help prevent age-related decline in integrity of human gut

Flies eating a Spartan diet are protected from leaky gut and the systemic inflammation associated with it as they age. Conversely, flies on a rich Atkins-like diet are more prone to developing intestinal permeability, a condition linked to a variety of human conditions including inflammatory bowel disease.

5 Nov 2018

MCG selected as designated laboratory for NCI-MATCH trial

The Georgia Esoteric and Molecular Laboratory at the Medical College of Georgia at Augusta University has been selected as a designated laboratory for the National Cancer Institute's Molecular Analysis for Therapy Choice, or MATCH trial, which is assessing the effectiveness of targeting cancer-causing gene changes rather than cancer type.

1 Nov 2018

Study: Single protein regulates network of genes essential for sperm development

A single protein regulates a battery of key genes inside developing sperm, according to a new study out of Case Western Reserve University School of Medicine.

31 Oct 2018

Individual heart cells respond differently to high blood pressure

A team of cardiologists have found that single cells within the heart are affected by high blood pressure in different ways. Some adapt, whilst others fail.

30 Oct 2018

Skin cells show minimal damage, maximum pigmentation when exposed to sunlight every 48 hours

Skin cells show the least amount of DNA damage and produce the most amount of melanin when exposed to sunlight in 48 hour windows, according to new study.

25 Oct 2018

Incyte announces Phase 2 FIGHT-202 trial data in patients with cholangiocarcinoma

Incyte Corporation announces updated data from its ongoing Phase 2 FIGHT-202 trial evaluating pemigatinib (INCB54828), its selective fibroblast growth factor receptor (FGFR) inhibitor, in patients with advanced/metastatic or surgically unresectable cholangiocarcinoma (bile duct cancer) who failed at least one previous treatment.

22 Oct 2018

Autonomic nervous system directly controls stem cell proliferation, study shows

Somatic stem cells are microscopic workhorses, constantly regenerating cells throughout the body: skin and the lining of the intestine, for example. And to University of Illinois neuroscientists, they represent untapped potential.

17 Oct 2018

Novel method uses just a drop of blood to monitor effect of lung cancer therapy

Dr Tasuku Honjo won the 2018 Nobel Prize in physiology or medicine for discovering the immune T-cell protein PD-1. This discovery led to a set of anti-cancer medications called checkpoint inhibitors, one of the first of which was nivolumab (Opdivo).

17 Oct 2018

Study uncovers important role of PRMT1 in dilated cardiomyopathy

In a study published in iScience, Professor Akiyoshi Fukamizu of the Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (University of Tsukuba, JAPAN) and the research group reported a new work on discovery of the important role of PRMT1 in dilated cardiomyopathy.

16 Oct 2018

Cell Proliferation News and Research

UC San Francisco scientists identify 'Achilles heel' of drug-resistant cancers

Researchers identify multisystem disorder caused by bi-allelic variants in CCDC47 gene

Towards finding a druggable cancer target

Surprising discovery about BH4 may rekindle interest in once-promising pathway

CRISPR-based tool shown to enhance cell-based immunotherapy

Two genomic tests help identify most effective treatment for breast cancer patients

Study defines biomarker in response to treatment of castration-resistant prostate cancer

Dietary restriction could help prevent age-related decline in integrity of human gut

MCG selected as designated laboratory for NCI-MATCH trial

Study: Single protein regulates network of genes essential for sperm development

Individual heart cells respond differently to high blood pressure

Skin cells show minimal damage, maximum pigmentation when exposed to sunlight every 48 hours

Incyte announces Phase 2 FIGHT-202 trial data in patients with cholangiocarcinoma

Autonomic nervous system directly controls stem cell proliferation, study shows

Novel method uses just a drop of blood to monitor effect of lung cancer therapy

Study uncovers important role of PRMT1 in dilated cardiomyopathy

Scientists perform successful trial of new antibiotic on cancer reoccurrence after surgery

Researchers deplete key protein for DNA replication using protein degradation system

Vitamin D may reduce breast cancer mortality in women with lower BMI

Researchers use CRISPR screen to reveal new targets in squamous cell carcinomas

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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