Crystallography News and Research

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Researchers make new advances in determining the structure of all possible DNA sequences

Oregon State University researchers have made significant new advances in determining the structure of all possible DNA sequences – a discovery that in one sense takes up where Watson and Crick left off, after outlining in 1953 the double-helical structure of this biological blueprint for life.

3 May 2005

Using X-ray crystallography, researchers have "seen" the structural basis for antibiotic resistanc

Using X-ray crystallography, researchers at Yale have "seen" the structural basis for antibiotic resistance to common pathogenic bacteria, facilitating design of a new class of antibiotic drugs, according to an article in Cell.

22 Apr 2005

Researchers make gains in understanding antibiotic resistance

Howard Hughes Medical Institute researchers chiseling away at the problem of antibiotic resistance now have a detailed explanation of how the drugs' main cellular target in bacteria evolves to become resistant to some of these medications.

22 Apr 2005

Researchers determine structure of binding site of colon-cancer drug Erbitux and its protein target

Researchers at the University of Pennsylvania School of Medicine have determined the precise molecular details of how Erbitux, a recently approved colorectal cancer drug, binds to its target on cancer cells. Knowing this chemical configuration will lead to better drug design for this family of cancer medications.

19 Apr 2005

Scientists reveal the shape of a protein that helps retroviruses break into cells

Retroviruses are among the trickier and more malicious disease agents, causing AIDS and cancers such as leukemia. The viruses manage to sneak into cells with the help of special protein assemblies scattered all over their surfaces. These retrovirus surface proteins cause the membrane envelope of the virus to fuse with the membrane of the cell, spilling virus RNA into the cell to wreak damage.

13 Apr 2005

Key target for Foot-and-Mouth drug revealed

A complete picture of Foot-and-Mouth Disease's key replication enzyme could lead to the development of new drugs to control the disease without recourse to vaccination or slaughter, scientists report today.

21 Mar 2005

New information that may help guide design of vaccines for HIV-1

Scientists have uncovered new information that may help guide design of vaccines for HIV-1, the virus that causes AIDS. A new detailed structural analysis of the complex formed by an anti-HIV antibody called 4E10 and its specific target provides insight into why this particular antibody is so broadly effective, a rare characteristic for HIV discovered thus far.

22 Feb 2005

Project makes Europe a leader in biocrystallography

A project to create a common platform throughout Europe for researchers working in the field of ‘biological crystallography’ is underway thanks to a grant of 10 million euros from the EU’s 6th Framework Programme (FP6).

8 Feb 2005

New ideas for creating a new generation of oral medications to treat infertility

Researchers now have a much better picture of how follicle-stimulating hormone (FSH), one of the most frequently used fertility drugs, works, and with it new ideas for creating a new generation of oral medications to treat infertility.

20 Jan 2005

New protein discovered holds promise for use in medicine and nanoscience

Researchers at the Hebrew University of Jerusalem have succeeded in discovering and isolating a new protein from the poplar tree with special structural and qualitative characteristics that could have consequences for development of future nanocapsules for drug delivery to cancer cells.

5 Jan 2005

Wide angle X-ray scattering (WAXS) could help produce lead drugs for disease therapy

Structural changes in proteins can now be seen in increased detail, using a new application of an existing technique. The application, developed at the U.S. Department of Energy's Argonne National Laboratory, could help produce lead drugs for disease therapy.

8 Dec 2004

New research is allowing biochemists to understand a key hierarchy of protein interactions that occurs in DNA

"All cancers are marked by some form of DNA replication gone awry, so a basic understanding of DNA replication is of paramount importance to those designing cancer-fighting drugs,"

8 Dec 2004

Gene decoding revealed at atomic level

A recent finding by a North Carolina State University biochemist advances the fundamental biology of how genetic information, encoded in DNA, is decoded for the production of proteins.

4 Dec 2004

Crystals may help to revolutionise drug discovery

A groundbreaking technique developed at The University of Manchester, which uses crystals to map ‘invisible’ parts of molecules, is set to revolutionise drug discovery.

From The University of Manchester 24 Nov 2004

Scientists have determined the crystal structure of a protein kinase C (PKC) isozyme

This structure should prove extremely useful in the rational design of small molecule inhibitors of PKCÈ, which has been implicated in T-cell mediated disease processes including inflammation and autoimmunity.

19 Nov 2004

Important advance in understanding the structure of phage viruses

An important advance in understanding the structure of phage viruses, which infect and destroy bacteria, has been made by a team of scientists from Oxford and Finland, which could help develop new strategies to combat bacterial infections.

11 Nov 2004

Atomic switch capable of discriminating color in a bacterial membrane protein

Researchers using extremely high resolution imaging have found an atomic switch capable of discriminating color in a bacterial membrane protein.

5 Nov 2004

Protein points to anticancer drug targets

A unique tail at one end of a protein called Ubc12 stabilizes a molecular workshop that assembles the “on-switch cells” used to accelerate cell replication.

20 Sep 2004

Scientist rewarded for breaking down transplant rejection

A scientist from Australia's Monash University who has recently determined the structure of drug that is widely used as an immunosuppressant, will be presented the 2004 Science Minister's Prize for Life Scientist of the Year.

8 Sep 2004

Flaw in DNA helps explain cancers and aging

Their finding explains how oxidative DNA damage - a process long believed to underlie cancers and aging - can create permanent genetic damage.

30 Aug 2004