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Rare and classic EGFR mutations have different impacts on NSCLC outcome

Certain rare epidermal growth factor receptor (EGFR) mutations are associated with tobacco smoking, worse prognosis and poor response to EGFR tyrosine kinase inhibitor (TKI) therapy compared to the more common "classical" EGFR mutations.

12 Feb 2015

Oral pathogen protects different tumor cells from being killed by immune cells

Bacteria that are commonly found in the mouth are often abundant in patients with colon cancer, but the potential role these microbes play in tumor development has not been clear. A study published by Cell Press February 18th in the journal Immunity reveals that the oral pathogen Fusobacterium nucleatum protects a variety of tumor cells from being killed by immune cells.

12 Feb 2015

Cumberland initiates clinical development of Boxaban (ifetroban) oral capsule for AERD treatment

Cumberland Pharmaceuticals Inc. today announced an expansion of its pipeline with a new Phase II development program. The Company has initiated the clinical development of Boxaban (ifetroban) oral capsule for the treatment of aspirin-exacerbated respiratory disease (AERD).

11 Feb 2015

Researchers close to novel therapy to treat levodopa-induced dyskinesia

Involuntary dyskinetic movements induced by treatment with levodopa (L-dopa) are a common problem for people with Parkinson's disease. Now, however, researchers at Karolinska Institutet and Lund University in Sweden seem to be close to a novel therapy to this distressing side effect.

11 Feb 2015

University of Tokyo researchers reveal how TLR9 binds to pathogen DNA

University of Tokyo researchers have elucidated how Toll-like receptor 9 (TLR9) binds to pathogen DNA, activating the innate immune system. This discovery is vital for the design of new antiviral, antibacterial, allergy and other drugs targeting TLR9.

10 Feb 2015

Psychedelic drug prevents allergic asthma in mouse model

Research led by Charles Nichols, PhD, Associate Professor of Pharmacology and Experimental Therapeutics at the LSU Health New Orleans School of Medicine, has found that a psychedelic drug, (R)-DOI, prevents the development of allergic asthma in a mouse model.

10 Feb 2015

Mice genetically deficient in serotonin are more vulnerable to social stressors

Mice genetically deficient in serotonin -- a crucial brain chemical implicated in clinical depression -- are more vulnerable than their normal littermates to social stressors, according to a Duke study appearing this week in the Proceedings of the National Academy of Sciences.

10 Feb 2015

Chili peppers show promise as diet-based supplement

Don't go chomping on a handful of chili peppers just yet, but there may be help for hopeful dieters in those fiery little Native American fruits.

9 Feb 2015

Helsinn begins elsiglutide Phase IIB trial for prevention of chemotherapy-induced diarrhea

Helsinn Healthcare S.A. and Zealand Pharma A/S jointly announce that Helsinn has started a Phase IIB clinical dose-finding trial of elsiglutide for the prevention of chemotherapy-induced diarrhea (CID). The first patients out of a planned total of 600 patients with colorectal cancer treated with chemotherapy have been dosed in the trial.

8 Feb 2015

Chinese researchers achieve major breakthrough in nano-carrier drugs for pancreatic cancer

At the "Symposium on the Application of Genetic Testing in Individualized Diagnosis and Treatment of Tumor" recently held in Tianjin, the research team led by Professor Hao Jihui of the Pancreas Oncology Department of Tianjin Medical University Cancer Hospital announced that they had achieved a major breakthrough in the field of nano-carrier drugs for pancreatic cancer.

6 Feb 2015

Recipients of The 2015 Protein Society Awards announced

The Protein Society, the premiere international society dedicated to supporting protein research, announces the winners of The 2015 Protein Society Awards. The awards will be conferred at the 29th Annual Symposium of The Protein Society (July 22-25, 2015, Barcelona, Spain).

5 Feb 2015

Study could lead to potential drug treatment for fighting addiction

A research team led by the University of Colorado Boulder has discovered a mechanism in the brain that is key to making cocaine seem pleasurable, a finding that could lead to a drug treatment for fighting addiction.

5 Feb 2015

Diplomat to dispense FDA-approved IBRANCE (palbociclib) to treat metastatic breast cancer

Diplomat Pharmacy, Inc., the nation's largest independent specialty pharmacy, announced today it will dispense Pfizer's new breakthrough medication, IBRANCE (palbociclib), starting tomorrow, Feb. 5.

4 Feb 2015

Cooking foods at high temperatures increases Alzheimer's risk

Our new paper published in the Journal of Alzheimer's Disease provides evidence that cooking foods at high temperatures increases the risk of Alzheimer's disease. This study looked at the content of advanced glycation end products (AGEs) in national diets and clinical studies comparing and compared total AGEs to Alzheimer's disease rates.

4 Feb 2015

New drug gets FDA approval for treatment of women with advanced breast cancer

The U.S. Food and Drug Administration today approved a potentially groundbreaking new drug to treat women with advanced breast cancer, signaling a new treatment strategy to arrest tumor growth and extend the time before the cancer worsens.

4 Feb 2015

Merck announces US availability of BELSOMRA (suvorexant) for treatment of insomnia

Merck, known as MSD outside the United States and Canada, today announced that BELSOMRA (suvorexant) is now available at pharmacies in the United States for the treatment of insomnia in adults who have difficulty falling asleep and/or staying asleep.

4 Feb 2015

New study helps explain how booster shots trigger immune 'memory' to improve

The last time you were in the doctor's office for a vaccine booster shot, did you wonder why you needed one? Exactly how booster shots offer long-term protection from viruses has long been a mystery to scientists.

3 Feb 2015

Not all ARB drugs are equally effective at treating heart failure, reveals NSU researcher

Millions of people take angiotensin receptor blockers (ARBs) to help treat heart failure. But it turns out not all ARBs are created equally, according to one Nova Southeastern University researcher's findings.

3 Feb 2015

Research shows olfactory proxy detection is a phenomenon in both insects and humans

Antioxidants are natural food ingredients that protect cells from harmful influences. Their main task is to neutralize so-called "free radicals" which are produced in the process of oxidation and which are responsible for cell degeneration.

2 Feb 2015

Researchers reveal why many African-American women are diagnosed with deadly forms of breast cancer

Researchers have uncovered new information that may begin to explain why many African-American women are more likely to be diagnosed with aggressive, often deadly forms of breast cancer, which strengthens the evidence that increased dietary folate intake may prove to be an effective strategy for reducing risk for the disease in African-American women.

31 Jan 2015

Receptor News and Research

Rare and classic EGFR mutations have different impacts on NSCLC outcome

Oral pathogen protects different tumor cells from being killed by immune cells

Cumberland initiates clinical development of Boxaban (ifetroban) oral capsule for AERD treatment

Researchers close to novel therapy to treat levodopa-induced dyskinesia

University of Tokyo researchers reveal how TLR9 binds to pathogen DNA

Psychedelic drug prevents allergic asthma in mouse model

Mice genetically deficient in serotonin are more vulnerable to social stressors

Chili peppers show promise as diet-based supplement

Helsinn begins elsiglutide Phase IIB trial for prevention of chemotherapy-induced diarrhea

Chinese researchers achieve major breakthrough in nano-carrier drugs for pancreatic cancer

Recipients of The 2015 Protein Society Awards announced

Study could lead to potential drug treatment for fighting addiction

Diplomat to dispense FDA-approved IBRANCE (palbociclib) to treat metastatic breast cancer

Cooking foods at high temperatures increases Alzheimer's risk

New drug gets FDA approval for treatment of women with advanced breast cancer

Merck announces US availability of BELSOMRA (suvorexant) for treatment of insomnia

New study helps explain how booster shots trigger immune 'memory' to improve

Not all ARB drugs are equally effective at treating heart failure, reveals NSU researcher

Research shows olfactory proxy detection is a phenomenon in both insects and humans

Researchers reveal why many African-American women are diagnosed with deadly forms of breast cancer

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

Breathing New Life into Diagnostics: Plasmion's SICRIT Technology

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