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Researchers highlight the extent to which NAFLD and diabetes jointly occur worldwide

Non-alcoholic fatty liver disease (NAFLD) has become an epidemic, similar to the non-communicable diseases cancer, obesity, cardiovascular disease and diabetes.

18 Feb 2022

Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

Codiak BioSciences, Inc., a clinical-stage biopharmaceutical company pioneering the development of exosome-based therapeutics as a new class of medicines, today announced the online publication of a new manuscript, Exosome mediated genetic reprogramming of tumor associated macrophages by exoASO-STAT6 leads to potent monotherapy anti-tumor efficacy, in the American Association for the Advancement of Science's journal, Science Advances.

18 Feb 2022

Novel approach pinpoints genetic variants involved in congenital heart disease

Nearly 1 percent of all children are born with congenital heart disease - a range of potentially life-threatening problems with the structure and function of their hearts. For most children, the precise causes of these frightening defects are unknown.

18 Feb 2022

Study reports a highly attenuated SARS-CoV-2 that could serve as a live-attenuated vaccine platform

The research showed a highly attenuated SARS-CoV-2 strain that might be used as a live-attenuated vaccine platform and a BSL-2 experimental system.

18 Feb 2022

Impact of several ACE2 coding missense variants and their effect on ACE2 protein subcellular localization and trafficking

Researchers investigated the connecting link between viral genetic variability and clinical heterogeneity of COVID-19 by analyzing the effect of several missense mutations on the ACE2 receptor coding sequence.

18 Feb 2022

Novel blood biomarkers can potentially predict melanoma patients' response to immunotherapy

Melanoma, a type of skin cancer, is often curable when detected and treated in its early stages. However, the disease can rapidly spread to other organs in the body and become deadly. According to the American Cancer Society, more than 7,600 people die of the disease each year in the United States.

17 Feb 2022

Research shows alterations in transfer RNAs at the epigenetic level in cancer

A recently published paper in the journal Molecular Cancer by the group of Dr. Manel Esteller, Director of the Josep Carreras Leukaemia Research Institute, ICREA Research Professor and Genetics Chairman at the University of Barcelona, shows that transfer RNAs for certain amino acids are altered at the epigenetic level in some types of cancer, expressing it in an exaggerated manner in some cases and being deficient in others.

17 Feb 2022

New research shines light on mysterious dynamics that define the interplay between nerves and muscle

New research co-led by a University of Ottawa Faculty of Medicine professor is shedding light on some of the mysterious dynamics that define the interplay between nerves and muscle.

17 Feb 2022

New finding may aid in development of vaccines against future animal-to-human viral diseases

A future vaccine providing protection against a wide range of coronaviruses that jump from their original animal hosts to humans - including SARS-CoV-2, the cause of COVID-19 - may be possible, say Johns Hopkins Medicine researchers, based on findings from their recent study.

17 Feb 2022

New open-source software tool could accelerate genetic discoveries

Commercially viable biofuel crops are vital to reducing greenhouse gas emissions, and a new tool developed by the Center for Advanced Bioenergy and Bioproducts Innovation should accelerate their development - as well as genetic editing advances overall.

17 Feb 2022

New mutation may define a high-risk subtype of pediatric acute myeloid leukemia

A new mutation was identified in 9 percent of relapsed cases of pediatric acute myeloid leukemia (AML) that may define a new subtype of the disease.

17 Feb 2022

MRI screenings may reduce breast-cancer mortality in women with 3 pathogenic gene variants

Annual MRI screenings starting at ages 30 to 35 may reduce breast-cancer mortality by more than 50% among women who carry certain genetic changes in three genes, according to a comparative modeling analysis to be published Feb. 17, 2022, in JAMA Oncology.

17 Feb 2022

New high-risk subtype of relapsed pediatric AML revealed

When acute myeloid leukemia (AML) relapses, it is more difficult to treat and outcomes are dismal. Scientists at St. Jude Children's Research Hospital have discovered a mutation in pediatric AML that physicians can use to identify high-risk patients and better guide treatment.

17 Feb 2022

Optical genome mapping holds potential to become an important component of leukemia diagnostics

Optical genome mapping involves the extraction of very long DNA molecules, for example routinely collected blood samples or bone marrow material from patients.

17 Feb 2022

Search for a treatment to stop nerve cell degeneration yields promising results

Researchers at the University of Illinois Chicago found promising results in their search for a treatment to stop nerve cell degeneration that happens in some types of disorders, such as hereditary spastic paraplegia and Parkinson's disease, which can cause significant disability.

17 Feb 2022

Study shows how some cancer cells immobilize T cells

Our immune systems have the potential to find and destroy cancer cells. But cancer cells can be clever and develop tricks to evade the immune system.

16 Feb 2022

Study investigates what causes blood malignancies linked to gene therapy for sickle cell disease

Gene therapy trials for sickle cell disease have been showing great promise, even offering hope of a cure. But in early 2021, the trials ground to a halt after reports of blood malignancies in two people in a trial sponsored by bluebird bio.

16 Feb 2022

New insights into why women develop Alzheimer's symptoms earlier and exhibit faster memory decline

A joint study by Nanyang Technological University, Singapore and National University of Singapore (NUS) scientists has examined why, in mice, female brains are more predisposed to Alzheimer's disease and other neurodegenerative diseases.

16 Feb 2022

Twin study identifies the influence of environment and genetics in multiple sclerosis

Researchers at the University of Zurich and Munich's LMU Klinikum hospital have studied the immune system of pairs of monozygotic twins to identify the influence of the environment and of genetics in cases of multiple sclerosis.

16 Feb 2022

Study helps understand actionable genetic variation affecting drugs in the Middle East population

A group of researchers at Qatar Foundation have reported the first comprehensive study of the distribution of actionable genetic variation affecting drugs in any Middle Eastern population, with potential implications for preemptive pharmacogenomic implementation in the region.

16 Feb 2022

Genetic News and Research

Researchers highlight the extent to which NAFLD and diabetes jointly occur worldwide

Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

Novel approach pinpoints genetic variants involved in congenital heart disease

Study reports a highly attenuated SARS-CoV-2 that could serve as a live-attenuated vaccine platform

Impact of several ACE2 coding missense variants and their effect on ACE2 protein subcellular localization and trafficking

Novel blood biomarkers can potentially predict melanoma patients' response to immunotherapy

Research shows alterations in transfer RNAs at the epigenetic level in cancer

New research shines light on mysterious dynamics that define the interplay between nerves and muscle

New finding may aid in development of vaccines against future animal-to-human viral diseases

New open-source software tool could accelerate genetic discoveries

New mutation may define a high-risk subtype of pediatric acute myeloid leukemia

MRI screenings may reduce breast-cancer mortality in women with 3 pathogenic gene variants

New high-risk subtype of relapsed pediatric AML revealed

Optical genome mapping holds potential to become an important component of leukemia diagnostics

Search for a treatment to stop nerve cell degeneration yields promising results

Study shows how some cancer cells immobilize T cells

Study investigates what causes blood malignancies linked to gene therapy for sickle cell disease

New insights into why women develop Alzheimer's symptoms earlier and exhibit faster memory decline

Twin study identifies the influence of environment and genetics in multiple sclerosis

Study helps understand actionable genetic variation affecting drugs in the Middle East population

Sequencing & Genomics: Elevating Science and Healthcare eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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