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Research provides drug developers with much needed insight into serotonin receptor

Serotonin, known as the "happiness" neurotransmitter, is a chemical found in the body responsible for feelings of well-being. But serotonin isn't the only chemical that binds to the 13 serotonin receptors found on the surface of cells. Far from it. Many approved drugs also bind to serotonin receptors.

21 Aug 2018

Aravive Biologics gains Fast Track Designation for AVB-S6-500 from U.S. FDA

Aravive Biologics, Inc. announced today that the U.S. Food and Drug Administration has granted Fast Track Designation to AVB-S6-500 as a potential treatment for platinum-resistant recurrent ovarian cancer.

20 Aug 2018

Saliva could modify dietary choices

Saliva is crucial for tasting and digesting food, but scientists have now found that it may have another, more subtle role.

20 Aug 2018

Study compares survival outcomes in rural and urban cancer patients enrolled in clinical trials

When enrolled in a cancer clinical trial, the differences in survival rates between rural and urban patients are significantly reduced, SWOG study results show.

17 Aug 2018

Research uncovers miscarriage cause, identifies potential targets for treatment

Tragic miscarriages for a couple have led to a discovery with potentially broad implications for future disease treatments, according to a team of researchers at the University of North Carolina School of Medicine. They identified a previously undiscovered gene mutation underlying hydrops fetalis – a fatal condition to fetuses due to fluid buildup in the space between organs.

16 Aug 2018

Microscopic insect odour detecting mechanisms discovered

Researchers at Rockefeller have used an ultra sensitive device to detect the olfactory systems of insects that help them smell out food and danger. The study titled, “Cryo-EM structure of the insect olfactory receptor Orco,” on the ion channels that form the basis of the odour detecting systems of insects was published in the latest issue of the journal Nature.

16 Aug 2018

Trial shows PARP inhibitor as novel treatment option for patients with advanced breast cancers

In a randomized, Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, the PARP inhibitor talazoparib extended progression-free survival (PFS) and improved quality-of-life measures over available chemotherapies for patients with metastatic HER2-negative breast cancer and mutations in the BRCA1/2 genes.

16 Aug 2018

New HIV therapy suppresses viral replication and increases immune cells in drug-resistant patients

In a study, a new HIV drug reduced viral replication and increased immune cells in individuals with advanced, drug-resistant HIV infection. Used in combination with existing HIV medications, the drug is a promising strategy for patients who have run out of effective treatment options, the researchers said.

16 Aug 2018

Researchers discover new promising target point for cancer and diabetes therapies

If certain signaling cascades are misregulated, diseases like cancer, obesity and diabetes may occur. A mechanism recently discovered by scientists at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie in Berlin and at the University of Geneva has a crucial influence on such signaling cascades and may be an important key for the future development of therapies against these diseases.

15 Aug 2018

New research confirms link between DDT exposure and autism

The results of a national birth cohort study published today provide biomarker evidence that DDT increases the risk of autism.

15 Aug 2018

Cruciferous vegetables found to protect against colon cancer in mice

Researchers have revealed how vegetables such as broccoli, cabbage and kale help to maintain a healthy gut and protect against colon cancer.

15 Aug 2018

Male tobacco smokers have decreased number of cannabinoid CB1 receptors, study reveals

Chronic, frequent tobacco smokers have a decreased number of cannabinoid CB1 receptors, the "pot receptor", when compared with non-smokers, reports a study in Biological Psychiatry.

15 Aug 2018

New model of genetically engineered immune cells may help fight solid tumors

Scientists at Memorial Sloan Kettering Cancer Center announced that they have built a new model of genetically engineered immune cells in mice that may allow them to fight solid tumors.

15 Aug 2018

Clinical study suggests new treatment direction for head and neck cancer in heavy smokers

Patients with a greater than 10 pack/year history of smoking tend to develop an especially dangerous form of head and neck squamous cell cancer for which prognosis remains poor and treatments have changed little during the past two decades.

14 Aug 2018

Study: IgG3 antibody stops B cells from fighting pathogens in HIV patients

For the first time, scientists have shown that in certain people living with HIV, a type of antibody called immunoglobulin G3 stops the immune system's B cells from doing their normal job of fighting pathogens.

14 Aug 2018

Researchers show how specialized nucleic acid-based nanostructures could help target cancer cells

More than 100 years ago, German Nobel laureate Paul Ehrlich popularized the "magic bullet" concept -- a method that clinicians might one day use to target invading microbes without harming other parts of the body. Although chemotherapies have been highly useful as targeted treatments for cancer, unwanted side effects still plague patients.

14 Aug 2018

Duke researchers track missing T-cells in glioblastoma patients

Glioblastoma brain tumors can have an unusual effect on the body's immune system, often causing a dramatic drop in the number of circulating T-cells that help drive the body's defenses.

13 Aug 2018

Long-term cannabinoid exposure impairs memory, study shows

A new study led by Ana Sebastião, group leader at Instituto de Medicina Molecular João Lobo Antunes and Professor of Faculdade de Medicina of Universidade de Lisboa and her team in collaboration with researchers from the University of Lancaster, shows that the long-term use of either cannabis or cannabis-based drugs impairs memory.

13 Aug 2018

Discovery could lead to new drugs against infection and inflammation

Researchers at Lund University in Sweden, have in collaboration with colleagues in Copenhagen and Singapore, mapped how the body's own peptides act to reduce infection and inflammation by deactivating the toxic substances formed in the process.

13 Aug 2018

UAB study shows how ion channel differentiates newborn and mature neurons in the brain

The dentate gyrus of the hippocampus is part of the brain that helps form memories. It is also one of just two areas in the adult brain where new neurons are continuously formed.

13 Aug 2018

Receptor News and Research

Research provides drug developers with much needed insight into serotonin receptor

Aravive Biologics gains Fast Track Designation for AVB-S6-500 from U.S. FDA

Saliva could modify dietary choices

Study compares survival outcomes in rural and urban cancer patients enrolled in clinical trials

Research uncovers miscarriage cause, identifies potential targets for treatment

Microscopic insect odour detecting mechanisms discovered

Trial shows PARP inhibitor as novel treatment option for patients with advanced breast cancers

New HIV therapy suppresses viral replication and increases immune cells in drug-resistant patients

Researchers discover new promising target point for cancer and diabetes therapies

New research confirms link between DDT exposure and autism

Cruciferous vegetables found to protect against colon cancer in mice

Male tobacco smokers have decreased number of cannabinoid CB1 receptors, study reveals

New model of genetically engineered immune cells may help fight solid tumors

Clinical study suggests new treatment direction for head and neck cancer in heavy smokers

Study: IgG3 antibody stops B cells from fighting pathogens in HIV patients

Researchers show how specialized nucleic acid-based nanostructures could help target cancer cells

Duke researchers track missing T-cells in glioblastoma patients

Long-term cannabinoid exposure impairs memory, study shows

Discovery could lead to new drugs against infection and inflammation

UAB study shows how ion channel differentiates newborn and mature neurons in the brain

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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