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Super-immunity in a camelid extensively immunized with the SARS-CoV-2 receptor-binding domain

A recent study published in Cell Reports reported the development of pan-sarbecovirus nanobodies (psNbs).

10 Jun 2022

First-in-class, anti-cancer mitochondrial drug found to be effective against most carcinoma cell lines

A study of the lead agent (CPI-613) in a class of anticancer drugs undergoing Food and Drug Administration (FDA) approved clinical trials reveals that CPI-613 is effective against most carcinoma cell lines, and, used in combination, could have efficacy against reducing some tumors.

9 Jun 2022

Cryo-EM helps scientists to decipher the structure of a key part of RNA degradation machinery

In biology, getting rid of stuff can be just as important as making it. A buildup of cells, proteins, or other molecules that are no longer needed can cause problems, so living things have evolved several ways to clean house.

9 Jun 2022

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

In a recent study posted to the bioRxiv* pre-print server, researchers examined how the interaction of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 8 (ORF8) protein with host dendritic cells (DCs) induced cytokine storm.

8 Jun 2022

Advanced microscopy techniques offer detailed insight into inner workings of cells' powerhouses

Using advanced microscopy techniques, researchers at Karolinska Institutet and Stockholm University in Sweden have visualized in unprecedented detail the machinery that the cells' powerhouses, the mitochondria, use to form their proteins.

8 Jun 2022

Discovery of small protein’s structure could lead to new therapies for neurological disorders

Scientists have, for the first time, revealed at the atomic level the structure of a protein that carries one of the body's most important neurotransmitters into neurons.

8 Jun 2022

New technology may enable rapid diagnosis of Ebola virus

A new tool can quickly and reliably identify the presence of Ebola virus in blood samples, according to a study by researchers at Washington University School of Medicine in St. Louis and colleagues at other institutions.

8 Jun 2022

New diagnostic procedure could help start optimal stroke treatment in a timely manner

A blood clot in the brain that blocks the supply of oxygen can cause an acute stroke. In this case, every minute counts.

8 Jun 2022

Open multiplexing with Cell DIVE offers cancer researchers more choices

Leica has introduced a new generation of its multiplexed imaging solution, Cell DIVE, including software and hardware improvements. The more scalable and efficient multiplexing platform addresses spatial cell biology and function within the tissue microenvironment

From Leica Microsystems GmbH 8 Jun 2022

Study offers clues about the shift of harmless environmental bacterium to a dreaded pathogen

Hospital-acquired infections (HAIs) are often particularly difficult to treat because the pathogens have developed resistance to common antibiotics.

3 Jun 2022

Immune modulator drugs improved clinical status, reduced deaths among patients hospitalized with COVID-19

A large randomized, placebo-controlled clinical trial led by the National Institutes of Health shows that treating adults hospitalized with COVID-19 with infliximab or abatacept - drugs widely used to treat certain autoimmune diseases - did not significantly shorten time to recovery but did substantially improve clinical status and reduce deaths.

2 Jun 2022

Scientists characterize a novel zoonotic coronavirus in humans

Scientists characterize the spike protein structure, entry receptors, and antigenicity of the newly emerged CCoV-HuPn-2018.

2 Jun 2022

Genetically modified herpes virus can be used in the fight against cancer

Viruses can make animals and humans sick - or healthy: Researchers at the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB have succeeded in genetically modifying the herpes simplex virus type 1, which triggers painful cold sores, in such a way that it can be used in the fight against cancer in the future.

1 Jun 2022

Combination bNAb therapy may offer a future alternative to daily ART for people living with HIV

Individuals with HIV who began taking antiretroviral therapy (ART) in the early stages of infection achieved a lengthy period of HIV suppression without ART after receiving two broadly neutralizing anti-HIV antibodies (bNAbs), according to a small study published today in the journal Nature.

1 Jun 2022

People with food allergies less likely to become infected with SARS-CoV-2, study finds

A National Institutes of Health-funded study has found that people with food allergies are less likely to become infected with SARS-CoV-2, the virus that causes COVID-19, than people without them. In addition, while previous research identified obesity as a risk factor for severe COVID-19, the new study has identified obesity and high body mass index (BMI) as associated with increased risk for SARS-CoV-2 infection.

1 Jun 2022

Researchers identify a human monoclonal antibody that could broadly neutralize several variants of SARS-CoV-2, SARS-CoV, and other coronaviruses

Researchers identified 10-40, a human monoclonal antibody with potent neutralizing activity against SARS-CoV, SARS-CoV-2, and related sarbecoviruses.

30 May 2022

Gene linked to severe learning disabilities plays a key role in cells' response to environmental stress

A gene that has been associated with severe learning disabilities in humans has been found to also play a vital role in cells' response to environmental stress, according to a Duke University study appearing May 24 in the journal Cell Reports.

27 May 2022

Understanding transposons provides a new starting point to generate more powerful gene editing tools

CRISPR has ushered in the era of genomic medicine. A line of powerful tools has been developed from the popular CRISPR-Cas9 to cure genetic diseases.

27 May 2022

Cryogenic electron microscopy used to determine the structure of fungal ribosome

Most people carry the fungus Candida albicans on their bodies, without this causing many problems. However, a systemic infection with this fungus is dangerous and difficult to treat.

25 May 2022

New imaging approach helps scientists build a complete picture of brain networks

Researchers at the Francis Crick Institute have developed an imaging technique to capture information about the structure and function of brain tissue at subcellular level – a few billionth of a metre, while also capturing information about the surrounding environment.

25 May 2022

Electron News and Research

Super-immunity in a camelid extensively immunized with the SARS-CoV-2 receptor-binding domain

First-in-class, anti-cancer mitochondrial drug found to be effective against most carcinoma cell lines

Cryo-EM helps scientists to decipher the structure of a key part of RNA degradation machinery

SARS-CoV-2 ORF8 protein binds to dendritic cells and induces a hyper-inflammatory cytokine storm

Advanced microscopy techniques offer detailed insight into inner workings of cells' powerhouses

Discovery of small protein’s structure could lead to new therapies for neurological disorders

New technology may enable rapid diagnosis of Ebola virus

New diagnostic procedure could help start optimal stroke treatment in a timely manner

Open multiplexing with Cell DIVE offers cancer researchers more choices

Study offers clues about the shift of harmless environmental bacterium to a dreaded pathogen

Immune modulator drugs improved clinical status, reduced deaths among patients hospitalized with COVID-19

Scientists characterize a novel zoonotic coronavirus in humans

Genetically modified herpes virus can be used in the fight against cancer

Combination bNAb therapy may offer a future alternative to daily ART for people living with HIV

People with food allergies less likely to become infected with SARS-CoV-2, study finds

Researchers identify a human monoclonal antibody that could broadly neutralize several variants of SARS-CoV-2, SARS-CoV, and other coronaviruses

Gene linked to severe learning disabilities plays a key role in cells' response to environmental stress

Understanding transposons provides a new starting point to generate more powerful gene editing tools

Cryogenic electron microscopy used to determine the structure of fungal ribosome

New imaging approach helps scientists build a complete picture of brain networks

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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