RNA Sequencing News and Research

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Study highlights role of tumor-infiltrating B cells, plasma cells in cancer development and treatment outcomes

Through extensive single-cell analysis, researchers at The University of Texas MD Anderson Cancer Center have created a spatial map of tumor-infiltrating B cells and plasma cells in early-stage lung cancers, highlighting previously unappreciated roles these immune cells play in tumor development and treatment outcomes.

13 Sep 2022

N-dihydrogalactochitosan shows promise as a mucosal vaccine adjuvant against SARS-CoV-2

In a recent study posted to the bioRxiv* server, researchers in the United States demonstrated the efficacy of a novel biopolymer, N-dihydrogalactochitosan (GC), as an adjuvant for next-generation mucosal coronavirus disease 2019 (COVID-19) vaccine.

12 Sep 2022

Small molecule inhibitor found to be effective against SARS-CoV-2 variants

In a new study, researchers developed RK-33, a small molecule inhibitor of DDX3, and evaluated its efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs).

12 Sep 2022

Techniques used for SARS-CoV-2 detection in body fluids

In a recent review published in the journal Trends in Analytical Chemistry, researchers provided a comprehensive overview of the current techniques used for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection in bodily fluids.

7 Sep 2022

Low-dose ketamine is safe and effective to treat children with ADNP syndrome, study suggests

Results of a small, but unique research study, led by researchers from the Seaver Autism Center for Research and Treatment at Mount Sinai and published online in Human Genetics and Genomic Advances, suggest that low-dose ketamine is generally safe, well-tolerated and effective to treat clinical symptoms in children diagnosed with ADNP syndrome (also known as Helsmoortel-VanDerAa syndrome), a rare neurodevelopmental disorder caused by mutations in the activity dependent neuroprotective protein (ADNP) gene.

6 Sep 2022

Lactate may have a previously unrecognized role in fighting cancer

A new study by UT Southwestern's Simmons Cancer Center scientists suggests that lactate, a metabolic byproduct produced by cells during strenuous exercise, can rejuvenate immune cells that fight cancer.

6 Sep 2022

Transcriptomic approach reveals shared classes of neuron types in reptilian and mammalian brains

These days, dragons are keeping Game of Thrones fans on their toes. But they are also providing important insights into vertebrate brain evolution, as revealed by the work of Max Planck scientists on the brain of the Australian bearded dragon Pogona vitticeps.

2 Sep 2022

Understanding how microglia change their states to adapt to different areas of the brain

In this interview, News Medical speaks to Jeffrey Stogsdill, Ph.D., about his latest research exploring how microglia change their state to adapt to different areas of the brain.

2 Sep 2022

Researchers discover new therapeutic target for triple-negative breast cancer

Breast cancer is categorized into three major subtypes: hormone receptor-positive, HER2-positive, and triple-negative.

29 Aug 2022

Study reveals clues what makes the human brain distinct from others

What makes the human brain distinct from that of all other animals - including even our closest primate relatives? In an analysis of cell types in the prefrontal cortex of four primate species, Yale researchers identified species-specific - particularly human-specific - features, they report Aug. 25 in the journal Science.

26 Aug 2022

Chinese researchers identify a new molecular mechanism of NASH pathogenesis

Nonalcoholic steatohepatitis (NASH), characterized by liver steatosis, inflammation and injury, has emerged as one of major causes for end-stage liver disease like hepatocellular carcinoma. However, what drives its progression?

25 Aug 2022

Researchers identify a potential new therapeutic approach to fight angioimmunoblastic T-cell lymphoma

A type of blood cell cancer called angioimmunoblastic T-cell lymphoma (AITL) can develop as mutations accumulate with age in the stem cells from which the T cells in the blood develop.

24 Aug 2022

How could SARS-CoV-2 viral infection modulate the immune landscape during the active infection phase and recovery in pregnant females?

Researchers examined immune reflexes towards SARS-CoV-2 infection among pregnant women.

24 Aug 2022

Host anti-viral factors and pathways regulating SARS-CoV-2 infection

In a new study, researchers identified host anti-viral factors and pathways regulating SARS-CoV-2 infection.

18 Aug 2022

Eating grapes may reduce the risk of fatty liver disease

In a recent study published in the journal Foods, eating grapes can extend life expectancy by five years and reduce non-alcoholic fatty liver disease risk in mice fed high-fat diets.

17 Aug 2022

New technique keeps the cells alive during RNA extraction

RNA sequencing allows scientists to study the expression of genes in a cell. Since messenger RNA (mRNA) is generated from a DNA gene, that information can be used to identify the original gene sequence and thus measure the activity of thousands of genes (i.e. the transcriptome) in these cells.

17 Aug 2022

Genetic variant associated with Alzheimer's disease plays a role in protecting against glaucoma

New research led by scientists at Mass Eye and Ear and Brigham and Women's Hospital, member hospitals of Mass General Brigham, reveals the role that a genetic variant associated with Alzheimer's disease, APOE4, plays in protecting against glaucoma.

16 Aug 2022

KAUST bioscientists develop new method to study the bone marrow microenvironment in greater detail

Deep molecular analysis of the bone marrow microenvironment reveals that the cells regulating blood stem cell maintenance are more diverse than expected and have features likely to be conserved between species.

16 Aug 2022

Researchers develop Cluster-Wells to facilitate the study of circulating tumor cells

Cancer spreads via circulating tumor cells (CTCs) that travel through the blood to other organs, and they are nearly impossible to track. Now, researchers at the Georgia Institute of Technology have found a detection method that could revolutionize cancer treatment by showing how cancers metastasize and what stage they are. This could lead to earlier and more targeted treatment, beginning with a simple blood test.

16 Aug 2022

PET imaging could help measure the pharmacodynamic effects of using STING-activating drugs

Stimulator of interferon genes, or STING, helps regulate immune activation. Thus, drugs that activate STING are being tested as a form of cancer immunotherapy and for treating certain infections.

11 Aug 2022

RNA Sequencing News and Research

Study highlights role of tumor-infiltrating B cells, plasma cells in cancer development and treatment outcomes

N-dihydrogalactochitosan shows promise as a mucosal vaccine adjuvant against SARS-CoV-2

Small molecule inhibitor found to be effective against SARS-CoV-2 variants

Techniques used for SARS-CoV-2 detection in body fluids

Low-dose ketamine is safe and effective to treat children with ADNP syndrome, study suggests

Lactate may have a previously unrecognized role in fighting cancer

Transcriptomic approach reveals shared classes of neuron types in reptilian and mammalian brains

Understanding how microglia change their states to adapt to different areas of the brain

Researchers discover new therapeutic target for triple-negative breast cancer

Study reveals clues what makes the human brain distinct from others

Chinese researchers identify a new molecular mechanism of NASH pathogenesis

Researchers identify a potential new therapeutic approach to fight angioimmunoblastic T-cell lymphoma

How could SARS-CoV-2 viral infection modulate the immune landscape during the active infection phase and recovery in pregnant females?

Host anti-viral factors and pathways regulating SARS-CoV-2 infection

Eating grapes may reduce the risk of fatty liver disease

New technique keeps the cells alive during RNA extraction

Genetic variant associated with Alzheimer's disease plays a role in protecting against glaucoma

KAUST bioscientists develop new method to study the bone marrow microenvironment in greater detail

Researchers develop Cluster-Wells to facilitate the study of circulating tumor cells

PET imaging could help measure the pharmacodynamic effects of using STING-activating drugs

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