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FDA grants orphan drug designation to Ultragenyx UX003 for treatment of MPS 7

Ultragenyx Pharmaceutical Inc., a biotechnology company focused on developing treatments for rare and ultra-rare genetic disorders, today announced that the FDA Office of Orphan Products Development has granted orphan drug designation for UX003 for the treatment of MPS 7.

28 Feb 2012

External cooling to achieve normothermia in patients with septic shock found safe

Fever control using external cooling in sedated patients with septic shock is safe and decreases vasopressor requirements and early mortality, according to a new study from researchers in France.

18 Feb 2012

FDA grants orphan drug designation to CSL Behring's rVIIa-FP

CSL Behring announced today that the company has been granted orphan drug designation by the U.S. Food and Drug Administration (FDA) for its novel recombinant fusion protein linking coagulation factor VIIa with albumin.

16 Feb 2012

UofL to receive Grand Challenges tuberculosis biomarkers grant

The University of Louisville announced today that it will receive a tuberculosis (TB) biomarkers grant through the Bill & Melinda Gates Foundation's Grand Challenges in Global Health program, an initiative which seeks to overcome persistent bottlenecks in creating new tools that can radically improve health in the developing world. James E. Graham, Ph.D., associate professor of microbiology and immunology at the UofL School of Medicine, will pursue an innovative research project to identify and validate TB biomarkers, titled "Disposable Sampling Plate and Breath Test to Identify Patients with Active Tuberculosis."

10 Feb 2012

Asthmatic mothers encouraged to breastfeed without fear as it boosts baby’s lung power: Study

In their study published in the American Journal of Respiratory and Critical Care Medicine they looked at nearly 1,500 children from birth to ages eight to 14. Parents provided information on breastfeeding history when their children were 12 months old, and the children had a series of tests to assess lung function between the ages of 8 and 14.

7 Feb 2012

Asian bird flu update for Ferbruary 2012

Health workers in Nepal are to cull thousands of chickens following the discovery of the H5N1 strain of bird flu in the southeastern part of the Himalayan country.

6 Feb 2012

Breastfeeding associated with improved lung function in children of asthmatic mothers

Breastfeeding is associated with improved lung function at school age, particularly in children of asthmatic mothers, according to a new study from researchers in Switzerland and the UK.

3 Feb 2012

Breastfeeding may improve lung function in school age children of asthmatic mothers

Breastfeeding is associated with improved lung function at school age, particularly in children of asthmatic mothers, according to a new study from researchers in Switzerland and the UK.

3 Feb 2012

CAT can assess exacerbation severity in patients with COPD

Exacerbation severity in patients with chronic obstructive pulmonary disease (COPD) can be reliably assessed with the COPD Assessment Test- (CAT), according to a new study from the UK.

27 Jan 2012

LCI feasible, sensitive non-invasive marker of early lung disease in young children with CF

The lung clearance index (LCI) is a sensitive non-invasive marker of early lung disease in young children with cystic fibrosis (CF), according to a new study from Australian researchers.

27 Jan 2012

RBC storage duration not associated with transfusion-related pulmonary complications

There is no difference in early measures of pulmonary function, immunologic status or coagulation status after fresh versus standard issue single-unit red blood cell (RBC) transfusion, according to a new study from the Mayo Clinic.

21 Jan 2012

Awake ECMO may be an effective bridging strategy for lung transplantation candidates

Extracorporeal membrane oxygenation (ECMO) support in awake, non-intubated patients may be an effective strategy for bridging patients to lung transplantation, according to a new study from Germany.

21 Jan 2012

Accelerated growth may increase risk of asthma symptoms in young children

Accelerated growth in the first three months of life, but not fetal growth, is associated with an increased risk of asthma symptoms in young children, according to a new study from The Generation R Study Group at Erasmus Medical Center in the Netherlands.

20 Jan 2012

First study to examine years of life lost in Brisbane climate change

Queensland University of Technology (QUT), in collaboration with CSIRO, has conducted a world-first study into the potential impact climate change will have on 'years of life lost' in Brisbane.

19 Jan 2012

Positive topline results from Civitas' CVT-301 Phase 1 trial on PD

Civitas Therapeutics, Inc., a privately-held pharmaceutical company developing transformative therapeutics using the ARCUS(TM) respiratory delivery platform, announced today positive topline results from a Phase 1 clinical trial for CVT-301, an inhaled formulation of levodopa (L-dopa) for the rapid relief from motor fluctuations associated with Parkinson's disease.

7 Jan 2012

Non-eosinophilic disease more prevalent in patients with mild-to-moderate asthma

A large percentage of patients with mild-to-moderate asthma have persistently non-eosinophilic disease which may not respond to currently available anti-inflammatory treatments, according to a new study.

6 Jan 2012

Statin use may influence susceptibility to ILD in smokers

Use of statins may influence susceptibility to or the progression of interstitial lung disease (ILD) in smokers, according to a new study.

6 Jan 2012

Task force identifies key themes and challenges in critical care research

To reduce mortality and improve patient care in the nation's ICUs, a task force formed by the Critical Care Societies Collaborative (CCSC), in conjunction with the US Critical Illness and Injury Trials Group (USCIITG) has recommended that research in the field become less fragmented and better account for patient heterogeneity and the complexity of critical illness.

4 Jan 2012

Truths and myths about pregnancy, obesity

Ironically, despite excessive caloric intake, many obese women are deficient in vitamins vital to a healthy pregnancy. This and other startling statistics abound when obesity and pregnancy collide. Together, they present a unique set of challenges that women and their doctors must tackle in order to achieve the best possible outcome for mom and baby.

22 Dec 2011

Second-hand smoke exposure during childhood associated with aspirin-exacerbated respiratory disease

Need another reason to keep your New Year's resolution to stop smoking? A first-of-its-kind study found adults with aspirin-exacerbated respiratory disease were more than three times as likely to have been exposed to second-hand smoke during childhood as those without the condition.

19 Dec 2011