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SARS-CoV-2 nucleocapsid G215C variation may explain Delta severity

A new study shows that the SARS-CoV-2 nucleocapsid protein has unique properties that allow the virus to become more infective in the presence of certain mutations.

11 Feb 2022

Study investigates population immunity to SARS-CoV-2 through heterogenous pathways

A new study demonstrates COVID-19 vaccine-specific differences in the antibody responses and memory B-cell immunity in a sample population comprising of 197 vaccinated individuals in Mexico.

11 Feb 2022

New COVID-19 test can determine if individuals have been vaccinated, infected, both, or neither

Researchers have created a new T cell assay that allows discrimination of COVID-19 infection and vaccination, as well as the order in which these occurred.

11 Feb 2022

Scientists identify multi-kinase inhibitors that can effectively block SARS-CoV-2-mediated cytokine release

Researchers investigated the efficacy of two multi-kinase inhibitors, olverembatinib and ponatinib, in inhibiting SARS-CoV-2 omicron-mediated cytokine release in human peripheral blood mononuclear cells.

10 Feb 2022

Omicron resists antibodies, causes less severe disease than previous SARS-CoV-2variants

In two recent studies, researchers at Washington University School of Medicine in St. Louis found evidence that the omicron variant of the virus that causes COVID-19 causes less severe disease than previous variants — at least in rodents — but that many antibody-based therapies may not be effective against it.

10 Feb 2022

Measuring T cell responses to SARS-CoV-2 vaccination and infection in healthcare workers with two different assays

The purpose of this study was to compare the OI TSPOT with the in-house PITCH ELISpot for reporting T cell responses specific to SARS-CoV-2 spike and structural proteins.

10 Feb 2022

Super-resolution imaging of the human coronavirus genome during infection

Using high-throughput confocal super-resolution microscopy, scientists visualize the genomic material of the human coronavirus HCoV-229E.

9 Feb 2022

Newborn antibodies following maternal COVID-19 vaccination persist for up to six months

A new study compares antibody levels in newborns born from mothers vaccinated against COVID-19 and to maternal infection with SARS-CoV-2.

9 Feb 2022

Induction and stability of vaccine-specific antibodies in multiple sclerosis patients on different disease-modifying therapies

Researchers have investigated the lack of response to treatment in certain multiple sclerosis patients.

9 Feb 2022

The B and T cell responses to SARS-CoV-2

Researchers assess the correlation between humoral and cell-mediated responses to SARS-CoV-2 in symptomatic and asymptomatic individuals.

8 Feb 2022

Study identifies lower viral load in the nasopharyngeal samples of patients infected with SARS-CoV-2 Omicron variant

In a new study, researchers determined if the higher transmission rate of the SARS-CoV-2 Omicron variant is due to a higher viral load compared to the Delta variant.

8 Feb 2022

SARS-CoV-2 cytokine storm inhibited by curcumin nanoparticles

In a recent study published in the journal ACS Applied Bio Materials, researchers demonstrated the inhibitory potential of curcumin-encapsulated polysaccharide nanoparticles (CUR−PS-NPs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (CoV2-SP)-stimulated cytokine storm in lung and liver epithelial cells.

8 Feb 2022

Memory B cells induced by mRNA vaccine may help generate antibodies against Omicron

In a recent research article published in the journal of Science Immunology, a team of researchers from Japan performed longitudinal analysis on the cellular composition of receptor-binding domain (RBD) memory B cell subsets and its antibody binding and neutralizing activity against the Beta, Delta, and Omicron variants following the second dose of a messenger ribonucleic acid (mRNA) vaccine.

8 Feb 2022

Spike Protein News and Research

SARS-CoV-2 nucleocapsid G215C variation may explain Delta severity

Study investigates population immunity to SARS-CoV-2 through heterogenous pathways

New COVID-19 test can determine if individuals have been vaccinated, infected, both, or neither

Scientists identify multi-kinase inhibitors that can effectively block SARS-CoV-2-mediated cytokine release

Omicron resists antibodies, causes less severe disease than previous SARS-CoV-2variants

Measuring T cell responses to SARS-CoV-2 vaccination and infection in healthcare workers with two different assays

Super-resolution imaging of the human coronavirus genome during infection

Newborn antibodies following maternal COVID-19 vaccination persist for up to six months

Induction and stability of vaccine-specific antibodies in multiple sclerosis patients on different disease-modifying therapies

The B and T cell responses to SARS-CoV-2

Study identifies lower viral load in the nasopharyngeal samples of patients infected with SARS-CoV-2 Omicron variant

SARS-CoV-2 cytokine storm inhibited by curcumin nanoparticles

Memory B cells induced by mRNA vaccine may help generate antibodies against Omicron

mRNA-based COVID-19 booster vaccination shown to protect against severe omicron infection in macaques

Study explores omicron-reactive T- and B- cell responses in COVID-19 vaccine recipients

A novel approach to predict mutations within the SARS-CoV-2 spike

Exploring the comparative efficacy of booster vaccines against SARS-CoV-2 Omicron and Delta variants

Predicting immunity evasion of SARS-CoV-2 Omicron variant of concern

Evaluating effects of D614G and P681R/H mutations on SARS-CoV-2 VOCs

Global efforts to track COVID-19 variants grossly underreported a probable variant of concern in Nigeria

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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