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Early promise for pulmonary artery denervation in PAH patients

Pulmonary artery denervation is feasible and may reduce pulmonary arterial pressure in patients with pulmonary arterial hypertension, phase II findings suggest.

11 Dec 2015

Mount Sinai scientists develop new tool to determine global role of microRNAs

As microRNA biology has been implicated in everything from the development of cancer to virus infections, a new tool developed by scientists at the Icahn School of Medicine at Mount Sinai holds tremendous potential to develop new therapies that involve these small regulatory fragments of RNA.

11 Dec 2015

Pathologic complete response after presurgery chemotherapy increases overall survival for TNBC patients

Patients with stage 2 or stage 3 triple-negative breast cancer (TNBC) who had a pathologic complete response (pCR) after presurgery chemotherapy had increased event-free and overall survival compared with those who had more than minimal residual invasive disease at surgery following presurgery chemotherapy, according to results from the randomized phase II CALGB/Alliance 40603 clinical trial presented at the 2015 San Antonio Breast Cancer Symposium, held Dec. 8-12.

11 Dec 2015

UC San Diego's Comprehensive Stroke Center receives Gold Plus Award

When someone experiences a major stroke, almost two million nerve cells in the brain die each minute, emphasizing the need for rapid treatment. Stroke patients who receive life-saving interventions more quickly have a higher chance of recovery. A recent data analysis showed the Comprehensive Stroke Center at UC San Diego Medical Center exceeded national average treatment times, and as a result, has received a "Get With The Guidelines-Stroke Gold Plus Quality Achievement Award" from The American Heart Association and American Stroke Association.

11 Dec 2015

Rowan University partners with DMHAS to provide treatment services for people with substance abuse disorders

The Department of Family Medicine at the Rowan University School of Osteopathic Medicine has entered into a two-year $973,000 agreement with the New Jersey Department of Human Services Division of Mental Health Addiction Services to provide early intervention and treatment services for individuals who have, or are at risk for, substance abuse disorders.

11 Dec 2015

Specific deep-brain circuit's firing frequency can alter forebrain activity, alertness levels

Adjusting a specific deep-brain circuit's firing frequency immediately and dramatically alters rats' forebrain activity and alertness levels, Stanford University School of Medicine investigators have shown.

11 Dec 2015

New heart failure drug may increase patients' risk of Alzheimer's disease, macular degeneration

Patients with mild heart failure stand to benefit from a new drug that can halt the progression of their disease and reduce their risk of cardiovascular-related death. But the drug -- a tablet that combines the agents valsartan and sacubitril, sold under the trade name Entresto by drugmaker Novartis -- may be too good to be true, according to Arthur M. Feldman, MD, PhD, Executive Dean of the Lewis Katz School of Medicine at Temple University, Chief Academic Officer of the Temple University Health System, and Laura H. Carnell Professor of Medicine at LKSOM.

10 Dec 2015

More than half of U.S. hospitals don't require flu shots for staff, new study finds

Within weeks, flu will start spreading across North America, sickening millions of people. It will hit people with health problems and weak immune systems hardest, and may kill tens of thousands of them.

10 Dec 2015

Study finds link between congenital heart disease and neurodevelopmental disorders

Researchers from Columbia University Medical Center, NewYork-Presbyterian, the Pediatric Cardiac Genetics Consortium, and the Pediatric Heart Network have found a number of genetic mutations that explain why many children with congenital heart disease also have other significant health challenges, including neurodevelopmental disorders and other congenital problems.

9 Dec 2015

Specific unmet socioeconomic needs can hamper quality of care patients receive, MGH study finds

A study of patients seen at two primary care practices at Massachusetts General Hospital has identified specific unmet socioeconomic needs that can interfere with the quality of care patients receive.

9 Dec 2015

Economic and racial barriers impact treatment of moderate to severe psoriasis

In the first known study to examine the prevalence and treatment of psoriasis in older Americans, experts from the Perelman School of Medicine at the University of Pennsylvania have found that black patients receiving Medicare are less likely to receive biologic therapies -medications derived from human or animal cells or tissues - for the treatment of moderate to severe psoriasis than white patients.

9 Dec 2015

Aspirin does not improve survival among breast cancer patients with aggressive disease

Whether aspirin may help prevent or reduce the risk of breast cancer remains a hotly debated research question. While past studies have indicated a potential benefit, most recently in hormone receptor-positive breast cancers, one new study from Penn Medicine suggests otherwise.

9 Dec 2015

Providing cancer patients with counseling before and after testing for genetic mutations decreases anxiety

Many BRCA 1/2-negative patients choose to proceed with comprehensive testing for genetic mutations that increase cancer risk, and when presented with counseling before and after testing, most make informed decisions and experience decreased levels of anxiety, according to new research from the Perelman School of Medicine at the University of Pennsylvania and the Basser Center for BRCA in Penn's Abramson Cancer Center.

9 Dec 2015

Palbociclib and paclitaxel combination shrinks tumors in patient with ER positive breast cancer

Combining the new breast cancer drug palbociclib with paclitaxel (Taxol) shrank tumors in nearly half of patient with estrogen-receptor (ER) positive breast cancer, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

9 Dec 2015

Treatment with antiplatelet therapy does not reduce pain crises in children with sickle cell disease

Treatment with the antiplatelet agent prasugrel does not significantly reduce the rate of pain crises or severe lung complications in children with sickle cell disease, according to a report published in the New England Journal of Medicine describing one of the largest and most geographically diverse international clinical trials on sickle cell disease to date.

9 Dec 2015

Novel antidepressant appears to be safe, effective against depression in clinical trial

A small clinical trial of a novel antidepressant that stimulates neurogenesis - the production of new brain cells - shows that the compound appears to be safe and may be effective against depression.

9 Dec 2015

Harvard's Kevin Staley honored with AES Research Recognition Award for Basic Science

The American Epilepsy Society announces that Kevin Staley, M.D., professor of child neurology and mental retardation at Harvard Medical School and chief of pediatric neurology at Massachusetts General Hospital, is being honored with the AES Research Recognition Award for Basic Science at the Society's 69th annual meeting in Philadelphia.

8 Dec 2015

Testing for developmental delay through an app? An interview with Dr. Clara Lajonchere

Cognoa's app helps every parent find out if their child’s development is on track and, if not, get their child the right help as early as possible.

8 Dec 2015

UB researchers develop a way to ramp up conversion of skin cells into dopamine neurons

For decades, the elusive holy grail in Parkinson's disease research has been finding a way to repair faulty dopamine neurons and put them back into patients, where they will start producing dopamine again. Researchers have used fetal material, which is difficult to obtain and of variable quality. Embryonic stem cells represented a tremendous innovation, but making dopamine neurons from stem cells is a long process with a low yield.

8 Dec 2015

Scientists reveal why loss of CD73 enzyme in human cancer promotes tumor progression

Scientists have shown for the first time why loss of the enzyme CD73 in human cancer promotes tumor progression.

8 Dec 2015

Medical School News and Research

Early promise for pulmonary artery denervation in PAH patients

Mount Sinai scientists develop new tool to determine global role of microRNAs

Pathologic complete response after presurgery chemotherapy increases overall survival for TNBC patients

UC San Diego's Comprehensive Stroke Center receives Gold Plus Award

Rowan University partners with DMHAS to provide treatment services for people with substance abuse disorders

Specific deep-brain circuit's firing frequency can alter forebrain activity, alertness levels

New heart failure drug may increase patients' risk of Alzheimer's disease, macular degeneration

More than half of U.S. hospitals don't require flu shots for staff, new study finds

Study finds link between congenital heart disease and neurodevelopmental disorders

Specific unmet socioeconomic needs can hamper quality of care patients receive, MGH study finds

Economic and racial barriers impact treatment of moderate to severe psoriasis

Aspirin does not improve survival among breast cancer patients with aggressive disease

Providing cancer patients with counseling before and after testing for genetic mutations decreases anxiety

Palbociclib and paclitaxel combination shrinks tumors in patient with ER positive breast cancer

Treatment with antiplatelet therapy does not reduce pain crises in children with sickle cell disease

Novel antidepressant appears to be safe, effective against depression in clinical trial

Harvard's Kevin Staley honored with AES Research Recognition Award for Basic Science

Testing for developmental delay through an app? An interview with Dr. Clara Lajonchere

UB researchers develop a way to ramp up conversion of skin cells into dopamine neurons

Scientists reveal why loss of CD73 enzyme in human cancer promotes tumor progression

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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