Stem Cells News and Research

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Stem cells have the remarkable potential to develop into many different cell types in the body during early life and growth. In addition, in many tissues they serve as a sort of internal repair system, dividing essentially without limit to replenish other cells as long as the person or animal is still alive. When a stem cell divides, each new cell has the potential either to remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell.

Researchers reprogram human embryonic stem cells to iPS cells for use in regenerative medicine

Human embryonic stem (ES) cells and adult cells reprogrammed to an embryonic stem cell-like state-so-called induced pluripotent stem or iPS cells-exhibit very few differences in their gene expression signatures and are nearly indistinguishable in their chromatin state, according to Whitehead Institute researchers.The pluripotency of ES cells fueled excitement over their use in regenerative medicine. While ethical hurdles associated with the clinical application of human ES cells appeared to have been overcome with the development of methods to create iPS cells, some recent research has suggested that ES and iPS cells have substantial differences in which sets of genes they express.

6 Aug 2010

Helmsley Charitable Trust awards $3.15M grant to support UofL James Graham Brown Cancer Center

The University of Louisville has received a $3.15 million grant from the Leona M. and Harry B. Helmsley Charitable Trust to support the UofL James Graham Brown Cancer Center and cancer research taking place in Owensboro. The grant will be matched with state "Bucks for Brains" funding to bring more than $4.5 million to the Owensboro Cancer Research Program.

6 Aug 2010

Scientists find new way to make beating heart cells from body's own cells

Scientists at the Gladstone Institute of Cardiovascular Disease have found a new way to make beating heart cells from the body's own cells that could help regenerate damaged hearts. Over 5 million Americans suffer from heart failure because the heart has virtually no ability to repair itself after a heart attack.

6 Aug 2010

Scientists find molecular cocktail to transform non-muscle cells into cardiac muscle

In heart disease, cardiac muscle gradually dies off and, with little or no way to regenerate those cells, that can ultimately lead the heart to fail. But scientists reporting in the August 6th issue of Cell, a Cell Press publication, might have found a way to fix those losses. They've devised a three-ingredient molecular cocktail that transforms fibroblasts - structural cells that the heart is chock full of - directly into beating heart cells.

6 Aug 2010

Cord Blood America strengthens balance sheet by reducing financial obligations

Cord Blood America, Inc., the umbilical cord blood stem cell preservation company focused on bringing the life saving potential of stem cells, a biological insurance policy, to families nationwide and internationally, today said that it has had positive movement on two financial obligations that further strengthen its balance sheet.

5 Aug 2010

Jagged2 gene essential for healthy development of teeth: Study

No healthy teeth without this gene: if during tooth formation (odontogenesis) the so-called Jagged2 gene is inactivated, and hence the Notch signalling pathway interrupted, tooth crowns will be malformed and enamel will be lacking. As this signalling pathway is involved in the formation of all tissues and organs, the new insights from the University of Zurich research team have wider implications.

5 Aug 2010

New study on decision making for infants with complex life threatening illnesses

Sharron Docherty understands that medical care for a critically ill infant involves much more than treatments designed to bring about a cure.

5 Aug 2010

TCA Cellular Therapy enrolls first patient for adult stem cell clinical trial

TCA Cellular Therapy, LLC has enrolled its first patient to participate in the U.S. Food and Drug Administration (FDA) first adult stem cell clinical trial to treat spinal cord injuries. Enrollee and Marine Veteran, Matt Cole was paralyzed from the chest down in a 2005 insurgent attack in Iraq.

5 Aug 2010

Scientists identify tiny RNA molecule that increases blood stem cells

Investigators have identified a new mechanism that controls the number of hematopoietic stem cells - cells that give rise to all blood and immune system cells. In a report in the online Early Edition of Proceedings of the National Academy of Sciences, researchers from Massachusetts General Hospital (MGH) and the Harvard Stem Cell Institute identify a tiny RNA molecule that increases the number of these blood stem cells, an advance that may improve treatment of blood system cancers.

5 Aug 2010

Sigma-Aldrich, NHLBI and BU collaborate in atherosclerotic cardiovascular disease research

Sigma-Aldrich® today announced it has entered into an agreement with the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health, and Boston University (BU) to develop methods to measure several potential biomarkers of atherosclerotic cardiovascular disease (CVD) using plasma samples from the NHLBI's Framingham Heart Study (FHS), one of the most prestigious clinical studies in medicine. Funding for the project is provided by the NHLBI to Sigma-Aldrich under a research subaward agreement with BU.

5 Aug 2010

Certain human leukemias can be treated by targeting stem-cell microRNAs: Research

Hematopoietic stem cells provide the body with a constant supply of blood cells, including the red blood cells that deliver oxygen and the white blood cells that make up the immune system. Hematopoietic-or blood-stem cells must also make more copies of themselves to ensure that they are present in adequate numbers to provide blood throughout a person's lifetime, which means they need to strike a delicate balance between self-renewal and development into mature blood-cell lineages. Perturb that balance, and the result can be diseases such as leukemia and anemia.

5 Aug 2010

Cardiogenesis second-quarter 2010 revenue increases 9% to $2.43 million

Cardiogenesis Corporation, a leading developer of surgical products used to treat cardiac patients suffering from severe angina, today reported financial results for its second quarter and first half ended June 30, 2010.

5 Aug 2010

New MIC platform measures cell-signaling pathways in brain tumor samples at single-cell level

New technologies for the diagnosis of cancer are rapidly changing the clinical practice of oncology. As scientists learn more about the molecular basis of cancer, the development of new tools capable of multiple, inexpensive biomarker measurements on small samples of clinical tissue will become essential to the success of genetically informed and personalized cancer therapies.

4 Aug 2010

Special issue on new developments in vestibular rehabilitation

Rehabilitation is essential for patients with disabling symptoms of dizziness, vertigo, and unsteadiness caused by disorders of the vestibular system. A special issue of The Journal of Neurologic Physical Therapy (JNPT) presents an update on new and emerging vestibular rehabilitation techniques, highlighting the physical therapist's role on the multidisciplinary teams providing patient care and research.

4 Aug 2010

Caliper Life Sciences second-quarter GAAP revenue decreases 10% to $29.0 million

Caliper Life Sciences, Inc., today reported results for its second quarter ended June 30, 2010. Second quarter GAAP revenue decreased 10% to $29.0 million from $32.1 million in the same period in 2009 as a result of divestitures in 2010 and 2009. Revenue from on-going business increased 4% on a reported basis and 6% on an organic basis (which assumes constant currency).

3 Aug 2010

Axiogenesis signs non-exclusive license agreement with iPS Academia

Axiogenesis AG and iPS Academia Japan Inc. (Kyoto, Japan) announced that they have executed a non-exclusive agreement with iPS Academia (Kyoto, Japan) through which Axiogenesis obtains worldwide access to the extensive portfolio of induced pluripotent stem cell technology for iPSC-derived cardiomyocytes and other cell types, pioneered by Professor Shinya Yamanaka, Center for iPS Cell Research and Application at the University of Kyoto, Japan.

3 Aug 2010

U.S. clinical trials provide further evidence of importance of storing umbilical cord blood

Cord Blood America, Inc., the umbilical cord blood stem cell preservation company focused on bringing the life saving potential of stem cells, a biological insurance policy, to families nationwide and internationally, today said that clinical trials ongoing in the U.S. using umbilical cord blood in the treatment of cerebral palsy, high-risk hematologic cancer, injured spinal cords and Type 1 diabetes provide significant further evidence of the importance of storing umbilical cord blood at the time of birth.

3 Aug 2010

Mount Sinai joins MMRC to develop new treatments for multiple myeloma

The Multiple Myeloma Research Consortium (MMRC) and Mount Sinai School of Medicine today announced that Mount Sinai has become the newest Member Institution to join the MMRC to accelerate the development of new treatments for multiple myeloma.

3 Aug 2010

Biomaterials-based bone grafts can manipulate cell behavior to repair injury

Scientists have developed a material for bone grafts that could one day replace the 'gold standard' natural bone implants.A new study shows how particles of a ceramic called calcium phosphate have the ability to stimulate promising bone regrowth by attracting stem cells and 'growth factors' to promote healing and the integration of the grafted tissue.

3 Aug 2010

New fat cell with potentially harmful characteristics: Study

The new fat cells arise from stem cells in the bone marrow that travel through the blood stream to fat tissue. They are termed bone marrow progenitor-derived adipocytes. The discovery also revealed that male and female subjects accumulate the new fat cells differently. The research also may help to explain the link between types of obesity and heart disease and other illnesses.

3 Aug 2010

Stem Cells News and Research

Further Reading

Researchers reprogram human embryonic stem cells to iPS cells for use in regenerative medicine

Helmsley Charitable Trust awards $3.15M grant to support UofL James Graham Brown Cancer Center

Scientists find new way to make beating heart cells from body's own cells

Scientists find molecular cocktail to transform non-muscle cells into cardiac muscle

Cord Blood America strengthens balance sheet by reducing financial obligations

Jagged2 gene essential for healthy development of teeth: Study

New study on decision making for infants with complex life threatening illnesses

TCA Cellular Therapy enrolls first patient for adult stem cell clinical trial

Scientists identify tiny RNA molecule that increases blood stem cells

Sigma-Aldrich, NHLBI and BU collaborate in atherosclerotic cardiovascular disease research

Certain human leukemias can be treated by targeting stem-cell microRNAs: Research

Cardiogenesis second-quarter 2010 revenue increases 9% to $2.43 million

New MIC platform measures cell-signaling pathways in brain tumor samples at single-cell level

Special issue on new developments in vestibular rehabilitation

Caliper Life Sciences second-quarter GAAP revenue decreases 10% to $29.0 million

Axiogenesis signs non-exclusive license agreement with iPS Academia

U.S. clinical trials provide further evidence of importance of storing umbilical cord blood

Mount Sinai joins MMRC to develop new treatments for multiple myeloma

Biomaterials-based bone grafts can manipulate cell behavior to repair injury

New fat cell with potentially harmful characteristics: Study

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