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Study reveals the LDLR pathway as a ubiquitous metabolic vulnerability in high grade gliomas

New research has shown that the blood vessels that feed aggressive brain tumors have receptors that could allow a new type of drug-containing nanoparticle to be used to starve the tumors of the energy they use to grow and spread, and also cause other disruptions to their adapted existence, even killing themselves.

7 Mar 2023

Denosumab may benefit postmenopausal patients with hormone receptor-negative breast tumors and RANK protein expression

The drug denosumab is currently used to treat osteoporosis and bone metastases. For more than a decade, its potential therapeutic benefit in the treatment of breast cancer has also been studied.

7 Mar 2023

Common scientific method to analyze DNA in early human embryos fails to accurately reflect gene edits

A commonly used scientific method to analyze a tiny amount of DNA in early human embryos fails to accurately reflect gene edits, according to new research led by scientists at Oregon Health & Science University.

7 Mar 2023

The effect of strawberry, blueberry, and strawberry-blueberry blend decoction-based functional beverages on obesity-related metabolic alterations

Researchers evaluated whether polyphenol-rich strawberry and blueberry decoction-based functional beverages could prevent obesity or related metabolic alterations in high-fat and high-fructose diet-fed rats.

7 Mar 2023

Yale scientists seek to identify optimal sequential treatments for advanced cancer

A team of Yale scientists seeks to determine which treatment sequences produce the best results for people with advanced cancer while examining the cost of these treatments.

6 Mar 2023

Antibody levels from prime COVID-19 mRNA vaccine influences the efficacy of booster doses

Researchers evaluate the response of pre-existing immunity to booster doses of mRNA COVID-19 vaccines.

6 Mar 2023

Aggression neurons activate while watching fights

A recent study discusses the processes and changes in the brain that arise while fighting and watching intense fights.

6 Mar 2023

Researchers investigate the potential effect of folic acid supplementation on DNA mutation rates

It is well established that folic acid supplementation can significantly reduce the risk of birth defects, including neural tube defects like spina bifida, the most common birth defect of the central nervous system and the second most common of all structural birth defects.

6 Mar 2023

Evaluating how bacterial therapeutics may synergize with existing anti-cancer therapies

It may come as a surprise, but bacteria love to grow inside tumors. It's the environment - tumors are typically acidic, have low amounts of oxygen, and are filled with dead cells, which all facilitate bacterial growth.

6 Mar 2023

'Good autoantibodies' associated with a milder course and lower risk of long Covid

Sometimes in the laboratory there are unexpected results. "Previously it had been observed that autoantibodies are common in severe Covid patients, those who end up in intensive care," says Jonathan Muri, postdoctoral fellow at the Institute for Research in Biomedicine (IRB, affiliated with the Università della Svizzera italiana) and co-author of the study.

6 Mar 2023

New research pinpoints key culprit behind brain cancer metastasis in children

New research pinpoints a key cause of metastasis from an aggressive form of brain cancer in children and provides a potential new therapy for treating these tumors in the future.

6 Mar 2023

How does chronic HBV infection affect flu and COVID-19 vaccine responses?

The influenza season marks the beginning of a time of illness, sometimes serious or even fatal, in much of the world. For this reason, flu shots are recommended, especially for individuals with underlying diseases such as chronic hepatitis B (CHB) infection, since they are at higher risk for adverse outcomes.

6 Mar 2023

Fighting pancreatic cancer with gene and cell biotherapies

Pancreatic cancer is an incurable form of cancer, and gene therapies are currently in clinical testing to treat this deadly disease. A comprehensive review of the gene and cell biotherapies in development to combat pancreatic cancer is published in the peer-reviewed journal Human Gene Therapy.

6 Mar 2023

Clinical trial shows safety and immunogenicity of temperature-stable experimental TB vaccine

A clinical trial testing a freeze-dried, temperature-stable experimental tuberculosis (TB) vaccine in healthy adults found that it was safe and stimulated both antibodies and responses from the cellular arm of the immune system.

6 Mar 2023

Researchers show how CBD can reduce seizures in treatment-resistant forms of childhood epilepsy

Researchers at Aston University have contributed to the discovery of a previously unknown way in which cannabidiol (CBD), a non-psychoactive component of cannabis, can reduce seizures in many treatment-resistant forms of childhood epilepsy.

6 Mar 2023

New ablation technology successful at eliminating episodes of abnormal heart rhythms

A new ablation technology known as pulsed-field ablation was successful at eliminating episodes of abnormal heart rhythms for 12 months in up to two-thirds of patients, according to a study being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

People with atopy have lower prevalence of cancers in extracutaneous sites and reduced melanoma risk

Fewer cases of melanoma were observed in people with a history of atopic diseases, such as allergic asthma or rhinitis, than in nonatopic people.

6 Mar 2023

BioInfect: Bringing the best brains to the challenge of antimicrobial resistance

During the conference, we had the chance to catch up with some of the speakers to ask them about their work, as well as what they would be discussing at the 2023 BioInfet Conference.

6 Mar 2023

Researchers optically evoke tachycardia enhanced anxiety-like behaviour

In a recent study published in the journal Nature, researchers devised a non-invasive optogenetic and wearable cardiac pacemaker for accurate and specific control of cardiac rhythm for ≤900 beats per minute (bpm), enabled by micro-light-emitting display (LED) harness and systemic channelrhodopsin delivery.

6 Mar 2023

Study reveals a chemical compound for the treatment of autoimmune diseases

Scientists in Japan have revealed a chemical compound that could be used for the treatment of various autoimmune diseases like multiple sclerosis and rheumatoid arthritis.

5 Mar 2023

B Cell News and Research

Study reveals the LDLR pathway as a ubiquitous metabolic vulnerability in high grade gliomas

Denosumab may benefit postmenopausal patients with hormone receptor-negative breast tumors and RANK protein expression

Common scientific method to analyze DNA in early human embryos fails to accurately reflect gene edits

The effect of strawberry, blueberry, and strawberry-blueberry blend decoction-based functional beverages on obesity-related metabolic alterations

Yale scientists seek to identify optimal sequential treatments for advanced cancer

Antibody levels from prime COVID-19 mRNA vaccine influences the efficacy of booster doses

Aggression neurons activate while watching fights

Researchers investigate the potential effect of folic acid supplementation on DNA mutation rates

Evaluating how bacterial therapeutics may synergize with existing anti-cancer therapies

'Good autoantibodies' associated with a milder course and lower risk of long Covid

New research pinpoints key culprit behind brain cancer metastasis in children

How does chronic HBV infection affect flu and COVID-19 vaccine responses?

Fighting pancreatic cancer with gene and cell biotherapies

Clinical trial shows safety and immunogenicity of temperature-stable experimental TB vaccine

Researchers show how CBD can reduce seizures in treatment-resistant forms of childhood epilepsy

New ablation technology successful at eliminating episodes of abnormal heart rhythms

People with atopy have lower prevalence of cancers in extracutaneous sites and reduced melanoma risk

BioInfect: Bringing the best brains to the challenge of antimicrobial resistance

Researchers optically evoke tachycardia enhanced anxiety-like behaviour

Study reveals a chemical compound for the treatment of autoimmune diseases

Immunology eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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