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Diabetes drug liraglutide ineffective in patients with advanced heart failure

In an attempt to correct defects in the energy generation that contributes to poor pump function among heart failure patients, researchers examined whether the diabetes drug liraglutide, could improve the condition of patients with advanced heart failure. Despite improvements in blood sugar control, the therapy did not improve the clinical stability or pumping action of the heart in patients with advanced heart failure.

9 Nov 2015

Scientists discover small molecule that can block growth of BRCA-deficient cancer cells

Cancer cells with mutations in BRCA1 or BRCA2 genes, which serve a vital role in preserving the integrity of the genetic code, are key targets for cancer therapeutics. Yet, few agents can selectively eliminate cells deficient in BRCA, and none can do so without the risk of inducing drug resistance.

6 Nov 2015

Main barriers to health coverage lie in perceived cost and knowledge gap, U-M study finds

If you need health care in rural Michigan, and you don't have insurance or money, you can turn to a free clinic -- like the one University of Michigan medical students run each Saturday in the tiny town of Pinckney. Fewer people need this kind of help these days, because of new insurance options made possible by the Affordable Care Act.

6 Nov 2015

UM SOM Dean E. Albert Reece to be honored with 2015 David E. Rogers Award

The Association of American Medical Colleges announced today that University of Maryland School of Medicine Dean E. Albert Reece, MD, PhD, MBA, will receive the 2015 David E. Rogers Award, which honors a medical school faculty member who has made major contributions to improving the health and health care of the American people. He will be presented the Award on November 8, 2015 at the AAMC's Annual Awards Event.

6 Nov 2015

Circulating protein predicts risk of chronic kidney disease

Make room, cholesterol. A new disease marker is entering the medical lexicon: suPAR, or soluble urokinase-type plasminogen activator receptor.

6 Nov 2015

Study suggests need for specific treatment options for adolescents with onset type 2 diabetes

New results from the Treatment Options for Type 2 Diabetes in Youth study (TODAY) examined predictors of the outcomes in youth with onset type 2 diabetes (T2D) based on early characteristics at diagnosis, and suggests the need for specific criteria for adolescents that are different from those in adults.

5 Nov 2015

JEDI T-cells provide unique technology to study, visualize immune responses and immunotherapies

When it comes to fending off disease and helping prevent people from falling ill, the body's immune system -- armed with T-cells that help eliminate cancer cells, virus-infected cells and more -- is second to none. But exactly how the immune system works remains, in many ways, a mystery, as there are numerous cell types whose functions and interactions with our immune systems have not been well understood.

5 Nov 2015

Hospital evidence-based practice centers can effectively inform decision-making in medical settings

Amid continued pressures to minimize errors and cut costs, hospitals are continuing to scramble to find solutions to problems plaguing health systems nationwide.

5 Nov 2015

Brain's hippocampus essential for recognizing previously encountered events

The hippocampus, a brain structure known to play a role in memory and spatial navigation, is essential to one's ability to recognize previously encountered events, objects, or people - a phenomenon known as recognition memory - according to new research from the departments of Neurosurgery and Psychology in the Perelman School of Medicine at the University of Pennsylvania.

4 Nov 2015

Denator forms a new Scientific Advisory Board

Denator AB has announced that a new external expert advisory board has been formed. Karsten Fjärstedt, recently appointed as CEO comments, “It is a great honor for me to be entrusted to lead Denator forward in this new phase of development. With a pipeline of new exciting business opportunities and a strong Scientific Advisory Board (SAB) I am looking forward to realizing the full potential of the company technology”.

3 Nov 2015

Alnylam presents positive ongoing phase 2 open-label extension data for Patisiran and Revusiran

Alnylam Pharmaceuticals, Inc. has announced new results from its ongoing Phase 2 open-label extension (OLE) studies with patisiran and revusiran, investigational RNAi therapeutics targeting transthyretin (TTR) for the treatment of TTR-mediated amyloidosis (ATTR amyloidosis).

3 Nov 2015

Researchers explore effects of hypoglycemia on cardiovascular autonomic control

Past studies have shown an association between strict control of blood sugar and increased mortality. These studies have also suggested that a consequence of this strict control is low blood sugar (called hypoglycemia), which may have adverse effects on the heart.

3 Nov 2015

Microbiome researcher Martin J. Blaser earns GUMC's Cura Personalis Award

Georgetown University Medical Center will bestow its highest honor, the Cura Personalis Award, upon Martin J. Blaser, MD, a world-renowned microbiome researcher and clinician.

3 Nov 2015

Pediatricians send away families who refuse to vaccinate their children

One in five pediatricians dismiss families who refuse to vaccinate their children, according to findings published today in the journal Pediatrics and based on research by faculty from the University of Colorado School of Medicine on the Anschutz Medical Campus.

3 Nov 2015

Patients with Down syndrome face additional challenge of early-onset dementia

Individuals with Down syndrome who survive into adulthood face the additional challenge of early-onset dementia, in which toxic amyloid plaques build up in the brain. The condition is strikingly similar to Alzheimer's disease, and as new work led by researchers at the Lewis Katz School of Medicine at Temple University shows, dementia in Down syndrome involves defects in a regulatory enzyme known as γ-secretase activating protein (GSAP), which also happens to malfunction in Alzheimer's disease.

3 Nov 2015

Findings suggest potential metabolic pathway against cancer

When cancer cells compete with immune cells for glucose, the cancer wins. As a result, the immune T cells are not healthy and don't have the weapons to kill the cancer.

3 Nov 2015

Discovery offers promising alternative to current therapies for AMD and ROP

A research team led by scientists at Beth Israel Deaconess Medical Center and the University of New Mexico School of Medicine has identified a small molecule that treats animal models of aged macular degeneration (AMD) and retinopathy of prematurity (ROP) by preventing the overgrowth of blood vessels that are characteristic of these two retinal diseases.

3 Nov 2015

Rheumatoid arthritis significantly increases risk of death due to cardiovascular causes

Rheumatoid arthritis (RA) has been associated with increased risk of death in the past, but a new study by investigators from Brigham and Women's Hospital brings that risk into sharper focus. Using data from the Nurses' Health Study, which has followed more than 100,000 female registered nurses since 1976, researchers found that rheumatoid arthritis significantly increased participants' overall risk of death, especially risk of death due to respiratory or cardiovascular causes.

3 Nov 2015

Key protein controls stem cell properties that could make them useful in regenerative medicine

A key protein controls stem cell properties that could make them more useful in regenerative medicine, according to a study led by Mount Sinai researchers and published online today in the journal Cell Stem Cell.

31 Oct 2015

Students introduced to da Vinci Robotic Surgical System at Saint Francis Memorial Hospital

On Tuesday, Oct. 27, fourth-through seventh-grade students from De Marillac Academy experienced first-hand what it is like to be a surgeon, thanks to the surgeons and operating room staff from Dignity Health Saint Francis Memorial Hospital.

31 Oct 2015

Medical School News and Research

Diabetes drug liraglutide ineffective in patients with advanced heart failure

Scientists discover small molecule that can block growth of BRCA-deficient cancer cells

Main barriers to health coverage lie in perceived cost and knowledge gap, U-M study finds

UM SOM Dean E. Albert Reece to be honored with 2015 David E. Rogers Award

Circulating protein predicts risk of chronic kidney disease

Study suggests need for specific treatment options for adolescents with onset type 2 diabetes

JEDI T-cells provide unique technology to study, visualize immune responses and immunotherapies

Hospital evidence-based practice centers can effectively inform decision-making in medical settings

Brain's hippocampus essential for recognizing previously encountered events

Denator forms a new Scientific Advisory Board

Alnylam presents positive ongoing phase 2 open-label extension data for Patisiran and Revusiran

Researchers explore effects of hypoglycemia on cardiovascular autonomic control

Microbiome researcher Martin J. Blaser earns GUMC's Cura Personalis Award

Pediatricians send away families who refuse to vaccinate their children

Patients with Down syndrome face additional challenge of early-onset dementia

Findings suggest potential metabolic pathway against cancer

Discovery offers promising alternative to current therapies for AMD and ROP

Rheumatoid arthritis significantly increases risk of death due to cardiovascular causes

Key protein controls stem cell properties that could make them useful in regenerative medicine

Students introduced to da Vinci Robotic Surgical System at Saint Francis Memorial Hospital

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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