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Developing a virtual twin for personalized cancer treatment with CAR-T cell therapy

In recent years, cancer immunotherapies have established themselves as a further pillar of medical oncology alongside traditional treatment options (surgery, radiotherapy and chemotherapy).

13 Dec 2023

Understanding why cutting-edge cell therapies cause an increased risk of heart rhythm disorders

A type of cell that plays a crucial role in tissue repair after a heart attack may also inadvertently be why cutting-edge cell therapies cause an increased risk of rhythm disorders, according to a new study from the Universities of Surrey and Oxford.

13 Dec 2023

Glycan analysis holds promise for early diagnosis of various cancers

In the future, a little saliva may be enough to detect an incipient cancer. Researchers at the University of Gothenburg have developed an effective way to interpret the changes in sugar molecules that occur in cancer cells.

13 Dec 2023

Organoid study opens new avenues in pulmonary neuroendocrine cancer therapy

Researchers performed a molecular analysis of neuroendocrine neoplasm (NEN) patient-derived tumor organoids (PDTOs) and their parental neoplasms.

13 Dec 2023

OHSU study sheds light on ubiquitin modification during bacterial infection

New research from Oregon Health & Science University could one day lead to therapies that prevent or treat diseases and infections tied to a protein that's found in all human cells.

12 Dec 2023

Stem cell therapy trial shows promise for regenerative treatment of heart failure

Stem cell-based therapy improved quality of life for patients with advanced heart failure, Mayo Clinic researchers and international collaborators discovered in a late-stage multinational clinical trial.

12 Dec 2023

Researchers find powerful combo weapon against aggressive lymphoma

The targeted therapy combination of ibrutinib and venetoclax significantly improved progression-free survival (PFS) and achieved an overall remission rate in 82% of patients with relapsed/refractory mantle cell lymphoma (MCL), according to researchers at The University of Texas MD Anderson Cancer Center. Results from the Phase III SYMPATICO trial were presented at the 2023 American Society of Hematology (ASH) Annual Meeting.

12 Dec 2023

Brainoware: A breakthrough AI approach using brain organoids for advanced computation

Study in Nature Electronics introduces "Brainoware," an innovative AI hardware approach using brain organoid neural networks for complex tasks like speech recognition and nonlinear dynamic predictions, demonstrating significant potential in AI development.

12 Dec 2023

Tat-heat shock protein 10 could rejuvenate aging brains

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 22, entitled, "Tat-heat shock protein 10 ameliorates age-related phenotypes by facilitating neuronal plasticity and reducing age-related genes in the hippocampus."

12 Dec 2023

Liquid biopsy may offer new tools for personalized immunotherapy in lung cancer

Using a "liquid biopsy" to study genetic material from tumors shed into the bloodstream together with immune cells could help clinicians predict which patients with advanced lung cancers are responding to immunotherapies and which patients may develop immune-related side effects several months later, according to research directed by investigators at the Johns Hopkins Kimmel Cancer Center, the Bloomberg~Kimmel Institute for Cancer Immunotherapy and Allegheny Health Network Cancer Institute in Pittsburgh.

12 Dec 2023

Daily consumption of prunes may reduce inflammation markers and bone loss effects

A new study published in The Journal of Nutrition shows daily consumption of prunes may reduce inflammation markers connected to bone signaling pathways and reduce the effects of bone loss among postmenopausal women.

12 Dec 2023

Scientists develop new system to display epitopes in mammal cells for immunization studies

A new paper in Biology Methods & Protocols, published by Oxford University Press, indicates that researchers in Germany have developed a new system to display epitopes in mammal cells for immunization studies.

12 Dec 2023

Study unlocks protein clues to aggressive lymphoma transformation

Researchers have come one step closer to answering why, in some patients, a type of lymphoma changes from indolent to aggressive, and in particular they are closer to identifying which patients are at high risk of this change happening.

12 Dec 2023

UVA atlas unveils cellular blueprint of atherosclerosis

University of Virginia School of Medicine researchers have created an "atlas of atherosclerosis" that reveals, at the level of individual cells, critical processes responsible for forming the harmful plaque buildup that causes heart attacks, strokes and coronary artery disease.

12 Dec 2023

New study unlocks hope for immunotherapy in metastatic prostate cancer

Immunotherapy has been disappointing as a prostate cancer treatment, but a new Columbia study suggests that the powerful treatments have potential when the disease starts to spread.

12 Dec 2023

Evaluation of immunogenicity-induced DNA vaccines against different SARS-CoV-2 variants

Five DNA vaccine candidates based on different SARS-CoV-2 strains.

12 Dec 2023

New optimized vaccine approach targets Hepatitis C virus variability

A method to design vaccines for highly variable viruses like the hepatitis C virus.

12 Dec 2023

Gene therapy shows promise for arrhythmogenic cardiomyopathy

Researchers evaluated the effectiveness of adeno-associated virus (AAV)-mediated Plakophilin 2 (PKP2) delivery in treating arrhythmogenic cardiomyopathy (ACM).

12 Dec 2023

Revolutionizing diabetes care: tPBM therapy proves effective in restoring microglial health

Transcranial photobiomodulation (tPBM) treatment affected insulin therapy on microglial function.

12 Dec 2023

New combination treatment offers hope for older patients with mantle cell lymphoma

The phase 2 trial PrE0405 met its primary endpoint, achieving a complete response (CR) rate of 85% in 33 patients over the age of 60 with mantle cell lymphoma (MCL) who received bendamustine and rituximab, a standard chemo-immunotherapy treatment, along with venetoclax, which is investigational in this setting.

11 Dec 2023

Cell News and Research

Developing a virtual twin for personalized cancer treatment with CAR-T cell therapy

Understanding why cutting-edge cell therapies cause an increased risk of heart rhythm disorders

Glycan analysis holds promise for early diagnosis of various cancers

Organoid study opens new avenues in pulmonary neuroendocrine cancer therapy

OHSU study sheds light on ubiquitin modification during bacterial infection

Stem cell therapy trial shows promise for regenerative treatment of heart failure

Researchers find powerful combo weapon against aggressive lymphoma

Brainoware: A breakthrough AI approach using brain organoids for advanced computation

Tat-heat shock protein 10 could rejuvenate aging brains

Liquid biopsy may offer new tools for personalized immunotherapy in lung cancer

Daily consumption of prunes may reduce inflammation markers and bone loss effects

Scientists develop new system to display epitopes in mammal cells for immunization studies

Study unlocks protein clues to aggressive lymphoma transformation

UVA atlas unveils cellular blueprint of atherosclerosis

New study unlocks hope for immunotherapy in metastatic prostate cancer

Evaluation of immunogenicity-induced DNA vaccines against different SARS-CoV-2 variants

New optimized vaccine approach targets Hepatitis C virus variability

Gene therapy shows promise for arrhythmogenic cardiomyopathy

Revolutionizing diabetes care: tPBM therapy proves effective in restoring microglial health

New combination treatment offers hope for older patients with mantle cell lymphoma

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