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Biomarker study reveals the effects of astrocyte reactivity in preclinical Alzheimer's disease

Evidence supports a close link between Aβ, astrocyte reactivity, and tau pathology in preclinical AD.

31 May 2023

Link confirmed: Infant RSV infections increase likelihood of childhood asthma

Research investigates the association between early-life respiratory syncytial virus (RSV) infection and the development of childhood asthma. It aims to assess the impact of RSV infection during infancy on the onset of wheezing illnesses and asthma in children.

30 May 2023

Artificial intelligence in sperm selection for assisted reproduction

Researchers summarize available evidence on the application of artificial intelligence and machine learning in sperm selection.

29 May 2023

Novel assay for identifying individuals with synucleinopathies using serum samples

Synucleinopathies are a group of neurodegenerative diseases caused by the abnormal accumulation α-synuclein, a protein normally found in the brain and neurons. Incorrect folding of α-synuclein leads to formation of 'seeds', which attract more α-synuclein proteins to form larger clumps.

29 May 2023

Gut bacteria toxins: A hidden trigger for Parkinson's disease?

Gut dysfunction and the presence of lipopolysaccharide (LPS) endotoxins contribute to the pathogenesis of Parkinson's disease (PD), leading to neuroinflammation and neurodegeneration. Modulating the gut microbiome and reducing LPS levels may hold potential as treatment strategies for PD.

24 May 2023

Surviving without glucose: uridine-derived ribose as an alternative energy source

Researchers attempted to identify new genes and molecular pathways that might supply energy when the availability of glucose or other nutrients is limited.

22 May 2023

Study shows the potential of TAp63 as a new therapeutic target for rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint deterioration. The clinical outcomes of patients with active RA can be improved using anti-rheumatic medications, such as methotrexate (MTX).

22 May 2023

Cross-reactivity between Epstein-Barr virus and protein in multiple sclerosis sheds light on disease development

Research uncovers the association between multiple sclerosis (MS) and antibody reactivity to specific amino acids in CRYAB, along with the increased risk when combined with high EBNA1 responses. The study provides evidence of antibody and T cell cross-reactivity between EBNA1 and CRYAB, highlighting the role of EBV adaptive immune responses in MS development.

21 May 2023

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Research describes the development of a synthetic delivery vector called STxB for mucosal vaccination. It induces mucosal immunity, including resident memory CD8+ T cells and IgA antibodies, against antigens derived from mucosal viruses when administered intranasally in mice.

21 May 2023

Efficient assay system aids rapid genetic diagnosis of mitochondrial diseases

The gene ECHS1 encodes for enoyl-CoA hydratase short-chain 1, a mitochondrial enzyme involved in branched-chain amino acid and fatty acid metabolism.

18 May 2023

Using synthetic peptides for inflammatory disease diagnosis

Scientists have developed a peptide that binds to the protein calprotectin, a marker of major inflammatory disorders, and shown that it is suitable for diagnostic tests.

17 May 2023

Ticks found to harbor and release prions of chronic wasting disease

Researchers determined whether ticks contain transmission-relevant amounts of chronic wasting disease.

17 May 2023

Novel antibodies target human receptors to neutralize SARS-CoV-2 variants and future sarbecoviruses

Researchers generated six human monoclonal antibodies that prevented infection.

17 May 2023

New process for automated and highly accurate reporting of NGS-based clonality testing

A new research paper was published in Oncotarget's Volume 14 on May 12, 2023, entitled, "Development and implementation of an automated and highly accurate reporting process for NGS-based clonality testing."

16 May 2023

HER2-TPMC proves to be a reasonable alternative for HER2-positive cancer chemotherapeutics

Announcing a new article publication for BIO Integration journal. Antibody-drug conjugates (ADCs) have the following advantages: target specificity; wide therapeutic index; and prolonged circulation half-life.

15 May 2023

Nanoparticles take aim at COVID-19 with lysosome-targeted delivery

Researchers discuss the use of endo-lysosome-targeted nanoparticles for delivering antiviral therapy to treat coronavirus infections.

15 May 2023

Swiss researchers identify plastic-degrading microbial strains in the Alps and Arctic region

Finding, cultivating, and bioengineering organisms that can digest plastic not only aids in the removal of pollution, but is now also big business.

13 May 2023

Could personalized neoantigen vaccines prevent the recurrence of pancreatic cancer and increase patient survival?

Researchers conducted a phase I clinical trial of a personalized mRNA neoantigen vaccine.

12 May 2023

COVID-19 that occurs after vaccination carries a much lower risk of severe illness

COVID-19 vaccination associated with lower rates of ICU admission and in-hospital mortality during the dominance of the Delta and Omicron variants.

11 May 2023

Extracellular chaperones mediate the lysosomal degradation of misfolded proteins

When exposed to stressful conditions, several proteins tend to misfold and form aggregates inside or outside cells.

11 May 2023

Assay News and Research

Biomarker study reveals the effects of astrocyte reactivity in preclinical Alzheimer's disease

Link confirmed: Infant RSV infections increase likelihood of childhood asthma

Artificial intelligence in sperm selection for assisted reproduction

Novel assay for identifying individuals with synucleinopathies using serum samples

Gut bacteria toxins: A hidden trigger for Parkinson's disease?

Surviving without glucose: uridine-derived ribose as an alternative energy source

Study shows the potential of TAp63 as a new therapeutic target for rheumatoid arthritis

Cross-reactivity between Epstein-Barr virus and protein in multiple sclerosis sheds light on disease development

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Efficient assay system aids rapid genetic diagnosis of mitochondrial diseases

Using synthetic peptides for inflammatory disease diagnosis

Ticks found to harbor and release prions of chronic wasting disease

Novel antibodies target human receptors to neutralize SARS-CoV-2 variants and future sarbecoviruses

New process for automated and highly accurate reporting of NGS-based clonality testing

HER2-TPMC proves to be a reasonable alternative for HER2-positive cancer chemotherapeutics

Nanoparticles take aim at COVID-19 with lysosome-targeted delivery

Swiss researchers identify plastic-degrading microbial strains in the Alps and Arctic region

Could personalized neoantigen vaccines prevent the recurrence of pancreatic cancer and increase patient survival?

COVID-19 that occurs after vaccination carries a much lower risk of severe illness

Extracellular chaperones mediate the lysosomal degradation of misfolded proteins

eBook: Using iPSCs models for human disease research and drug discovery eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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