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Cocoa extract supplements linked to reduced inflammation in older adults

Could cocoa extract supplements rich in cocoa flavanols reduce inflammation and, in turn, prevent age-related chronic diseases? In a new study from the COcoa Supplement and Multivitamin Outcomes Study (COSMOS), investigators from Mass General Brigham and their colleagues looked at changes in five age-related markers of inflammation among participants who received daily cocoa supplements over several years.

17 Sep 2025

Can changing food texture reduce how much we eat? Dutch study investigates

A new randomized controlled trial protocol from the Netherlands will test whether altering the texture, and thus the eating rate, of ultra-processed foods can reduce daily energy intake. The study will investigate how sensory properties, such as food hardness, affect metabolism, appetite, and microbiome composition.

16 Sep 2025

Stem cell therapy restores brain function after stroke

Stem cell transplantation can reverse stroke damage, researchers at the University of Zurich report. Its beneficial effects include regeneration of neurons and restoration of motor functions, marking a milestone in the treatment of brain disorders.

16 Sep 2025

Survey shows high levels of mental health difficulties among young adults

The majority (64%) of young adults in Britain say they have experienced mental health difficulties, with a third (32%) expecting to need support in the coming year, according to polling commissioned from YouGov by UCL's Grand Challenge of Mental Health & Wellbeing.

16 Sep 2025

Foods taste sweeter or saltier than before for some people taking Ozempic, Wegovy or Mounjaro

New research being presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September) shows that some individuals who are taking Ozempic, Wegovy or Mounjaro find that foods taste sweeter or saltier than before.

16 Sep 2025

Personalized risk information does not increase colorectal cancer screening rates

A new Indiana University School of Medicine clinical trial - the largest of its kind to date - found that providing personalized colorectal cancer risk information to patients and their health care providers did not improve screening rates for the deadly ailment.

16 Sep 2025

Trauma-focused CBT could offer hope for young PTSD sufferers

A specialist form of therapy could offer hope for some of the most vulnerable young PTSD sufferers – according to a University of East Anglia study.

15 Sep 2025

Acupuncture improves pain and function in older adults with chronic low back pain

According to a study funded by the National Institutes of Health (NIH), older Americans with chronic low back pain who received acupuncture had greater improvement in physical function and reduced pain than those who received usual medical care only, generally prescribed medications or physical therapy.

13 Sep 2025

UCL launches landmark trial of Alzheimer’s blood test

A major UCL-led clinical trial, aiming to transform the diagnosis of Alzheimer's disease through a simple blood test, is now welcoming its first participants who will be recruited via memory clinics across the UK.

11 Sep 2025

Faster and cheaper MRI proves effective in detecting prostate cancer

A quicker, cheaper MRI scan was just as accurate at diagnosing prostate cancer as the current 30-40 minute scan and should be rolled out to make MRI scans more accessible to men who need one, according to clinical trial results led by UCL, UCLH and the University of Birmingham.

11 Sep 2025

Personalized form of electric brain stimulation shows promise for treating depression

A more precise and personalized form of electric brain stimulation may be a more effective and faster treatment for people with moderate to major depression compared to other similar treatments, according to a UCLA Health study.

11 Sep 2025

New care program aims to improve cancer treatment access for Indigenous patients

Researchers from the University of Oklahoma Health Campus have published an article in the New England Journal of Medicine describing a novel care coordination and communication program and its potential for helping Indigenous people access the lifesaving cancer care that they need.

11 Sep 2025

Driving performance unaffected in regular cannabis users after 48 hours of abstinence

Scientists from the Center for Medicinal Cannabis Research (CMCR) at the University of California San Diego School of Medicine found that, in the largest such study to date, frequent cannabis users did not display impairments in driving performance after at least 48 hours of abstinence.

11 Sep 2025

CRISPR-based therapeutic approach designed to treat fatal pediatric disease

Multisystemic smooth muscle dysfunction syndrome (MSMDS) is a rare condition associated with stroke, aortic dissection (tearing) and death in childhood.

11 Sep 2025

Elinzanetant reduces hot flashes in menopause

The OASIS-3 trial demonstrates elinzanetant's effectiveness in alleviating menopausal symptoms, reducing hot flashes significantly over a year-long study.

11 Sep 2025

GABA identified as key blocker of neural repair in spinal cord injury

Spinal cord injuries caused by external trauma, such as traffic accidents or falls, often lead to the permanent loss of motor and sensory functions.

10 Sep 2025

Rare ABCA7 gene variants linked to Alzheimer’s risk

A new study from MIT neuroscientists reveals how rare variants of a gene called ABCA7 may contribute to the development of Alzheimer's in some of the people who carry it.

10 Sep 2025

Subcutaneous amivantamab plus lazertinib yields high response in EGFR-mutant lung cancer

A new analysis from the PALOMA-2 study presented today shows that subcutaneous administration of amivantamab every four weeks (Q4W), in combination with daily oral lazertinib, yields a high objective response rate in patients with previously untreated EGFR-mutated advanced non-small cell lung cancer (NSCLC).

10 Sep 2025

Infant neurodevelopment not affected by brief inhaled anesthesia during surgery

Preliminary findings from a new clinical trial show no adverse neurodevelopmental effects after brief inhaled anesthesia and surgery in infants and young children, reports the Online First edition of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists.

10 Sep 2025

Combination immunotherapy prior to surgery shows encouraging results in mesothelioma

Results from an early phase clinical trial presented this week at the World Conference on Lung Cancer Meeting in Barcelona, Spain, and published in the Nature Medicine journal today [Monday, 8th September 2025] show that patients with mesothelioma - a rare cancer of the lining of the lung that may be caused by exposure to asbestos - who received a combination of two immunotherapy drugs, nivolumab and ipilimumab, before surgery had successful surgeries and encouraging early outcomes.

9 Sep 2025

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Clinical Trial News and Research

Cocoa extract supplements linked to reduced inflammation in older adults

Can changing food texture reduce how much we eat? Dutch study investigates

Stem cell therapy restores brain function after stroke

Survey shows high levels of mental health difficulties among young adults

Foods taste sweeter or saltier than before for some people taking Ozempic, Wegovy or Mounjaro

Personalized risk information does not increase colorectal cancer screening rates

Trauma-focused CBT could offer hope for young PTSD sufferers

Acupuncture improves pain and function in older adults with chronic low back pain

UCL launches landmark trial of Alzheimer’s blood test

Faster and cheaper MRI proves effective in detecting prostate cancer

Personalized form of electric brain stimulation shows promise for treating depression

New care program aims to improve cancer treatment access for Indigenous patients

Driving performance unaffected in regular cannabis users after 48 hours of abstinence

CRISPR-based therapeutic approach designed to treat fatal pediatric disease

Elinzanetant reduces hot flashes in menopause

GABA identified as key blocker of neural repair in spinal cord injury

Rare ABCA7 gene variants linked to Alzheimer’s risk

Subcutaneous amivantamab plus lazertinib yields high response in EGFR-mutant lung cancer

Infant neurodevelopment not affected by brief inhaled anesthesia during surgery

Combination immunotherapy prior to surgery shows encouraging results in mesothelioma

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