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Metabolic syndrome found to increase risk of breast cancer recurrence and death

New research to be presented at this year's European Congress on Obesity (ECO 2025, Malaga, Spain, 11-14 May) and published in The Journal of Internal Medicine shows that, in survivors of breast cancer, having an unhealthy metabolic profile or so called 'metabolic syndrome' increases the risk of breast cancer recurrence by 69%, and subsequent breast cancer mortality by 83%.

16 Apr 2025

Researchers simulate protein structures behind learning and memory

Our brain's remarkable ability to form and store memories has long fascinated scientists, yet most of the microscopic mechanisms behind memory and learning processes remain a mystery.

16 Apr 2025

Nasal protein levels may predict COVID-19 risk

Higher nasal expression of ACE2 and TMPRSS2 proteins can predict future SARS-CoV-2 infection.

16 Apr 2025

Understanding the natural history of SCN8A-related epilepsy disorders

Researchers from the Epilepsy Neurogenetics Initiative (ENGIN) at Children's Hospital of Philadelphia (CHOP) have completed a comprehensive natural history study of SCN8A-related disorders, which represent a spectrum of neurological symptoms.

15 Apr 2025

Multidimensional sleep health linked to better cardiometabolic outcomes

Healthy sleep includes multiple components, such as number of hours of sleep per night, how long it takes to fall asleep, daytime functioning and self-reported sleep satisfaction, and addressing these different dimensions of sleep may help to reduce cardiometabolic health and related risk factors, according to a new American Heart Association scientific statement published today in Circulation: Cardiovascular Quality and Outcomes.

14 Apr 2025

Weight-loss lifestyle changes slow bone loss in older adults

Researchers evaluate the effects of a weight-loss lifestyle intervention on age-related bone deterioration.

14 Apr 2025

Adolescent obesity in England rises by 50% over 15 years

New research to be presented at this year's European Congress on Obesity (ECO 2025, Malaga, Spain, 11-14 May) shows that the proportion of adolescents living with overweight or obesity in England has increased by 50% from 2008-2010 (22%) to 2021-2023 (33%).

12 Apr 2025

IL-6 emerges as early sepsis indicator in high risk groups

A pioneering study presented today at ESCMID Global 2025 has uncovered the potential of interleukin-6 (IL-6) as a powerful diagnostic biomarker for the early detection of sepsis in high-risk patient groups, including neonates, children and pregnant women.

11 Apr 2025

Understanding the complex spectrum of Castleman disease

Castleman disease (CD) is a rare, non-clonal lymphoproliferative disorder that manifests with a wide range of histologic and clinical features.

11 Apr 2025

UQ's new research center aims to improve lives of people living with pain

One of the world's foremost pain experts has highlighted the risks of bypassing established processes for assessing the safety and effectiveness of medicines at the launch of a research center at the University of Queensland.

10 Apr 2025

Refining the diagnosis of large granular lymphocytic leukemias and their mimics

Large granular lymphocytic leukemias (LGLLs) are a heterogeneous group of rare chronic lymphoproliferative disorders characterized by the clonal proliferation of cytotoxic lymphocytes. Among them, T-cell LGLL (T-LGLL) and NK-cell LGLL (NK-LGLL) are the most prominent.

10 Apr 2025

Survey reveals diverse practices in thoracic sympathetic surgery across Europe

Thoracic autonomic nervous system surgery is mainly used for hyperhidrosis/facial flushing, whereas cardiac and vascular indications are limited.

10 Apr 2025

Researchers uncover a new genetic cause of neurodevelopmental disorders

A seminal study from researchers at the Icahn School of Medicine at Mount Sinai and their collaborators in the United Kingdom, Belgium, Spain, the Netherlands, and Iceland has uncovered a new genetic cause of neurodevelopmental disorders (NDDs).

10 Apr 2025

New quinoline-based antiviral shows strong promise against SARS-CoV-2

Researchers develop quinoline-based drug with inhibitory activity against the SARS-CoV-2 papain-like protease (PLpro).

10 Apr 2025

AI-driven personalized nutrition shows promise in improving gut health

Researchers examine the impact of AI-based personalized nutrition programs on the gut microbiome of healthy individuals.

10 Apr 2025

Calibr-Skaggs receives FDA approval to test sCAR-T therapy in patients with autoimmune diseases

Calibr-Skaggs Institute for Innovative Medicines, the drug discovery division of Scripps Research, announced today that the FDA has cleared their investigational new drug (IND) application to study switchable chimeric antigen receptor T cell (sCAR-T) therapy (CLBR001 + SWI019) in patients with autoimmune conditions.

9 Apr 2025

Gut microbes and metabolites reveal how lifestyle changes help prevent type 2 diabetes

Researchers identified 502 blood metabolites linked to prediabetes and type 2 diabetes, with 143 tied to the gut microbiome. The study shows how lifestyle interventions like diet and exercise can modify metabolomic profiles to support glucose control.

9 Apr 2025

Oklahoma Children's Hospital improves care for babies with neonatal abstinence syndrome

In years past, health care providers took a punitive stance toward women giving birth to babies exposed to substances like opioids in the womb.

9 Apr 2025

Scientists stop long-COVID symptoms in mice using a new antiviral compound

Australian scientists developed a novel antiviral that targets the SARS-CoV-2 PLpro enzyme, showing strong preclinical efficacy in reducing both acute and long COVID symptoms in mice.

9 Apr 2025

Genetic breakthrough in psychiatry using long-read genomic sequencing

In a manuscript published today in the American Journal of Psychiatry titled Long-Read Genome Sequencing in Clinical Psychiatry: RFX3 Haploinsufficiency in a Hospitalized Adolescent With Autism, Intellectual Disability, and Behavioral Decompensation, authors describe how they leveraged long-read genomic sequencing (LRS) to make a genetic diagnosis in a17-year-old male with autism spectrum disorder, intellectual disability, and acute behavioral decompensation that would not have been possible by standard methods.

9 Apr 2025