Mutation News and Research

RSS

FDA grants Advaxis pre-IND meeting for ADXS-HER2 cancer immunotherapy

Advaxis, Inc., a leader in developing the next generation of immunotherapies for cancer and infectious diseases, has been granted a pre-Investigational New Drug meeting with the U.S. Food and Drug Administration on November 22nd, 2011 to discuss the initial clinical development plan for ADXS-HER2, a construct for the treatment of HER2 expressing cancers.

12 Oct 2011

NCCN Oncology Research Program wins two GSK grants

The National Comprehensive Cancer Network Oncology Research Program (ORP) has been awarded $4 million in the form of two research grants from GlaxoSmithKline (GSK) to develop studies to scientifically evaluate and define GSK2118436, a BRAF inhibitor, and GSK1120212, a MEK1 and MEK2 inhibitor. Previous research has indicated that BRAF mutations are strong targets for therapies in the treatment of advanced melanoma.

12 Oct 2011

Life Technologies launches Ion AmpliSeq Cancer Panel

Life Technologies Corporation today announced the launch of the Ion AmpliSeq Cancer Panel, enabling scientists to sequence dozens of genes in cancer research samples using a simple workflow.

12 Oct 2011

ASHG to honor U of U geneticist with William Allan Award

As a teenager just moved to Iowa from war-ravaged Germany in 1951, John M. Opitz, M.D., wanted to study developmental biology, but his "very Prussian" mother insisted he go to medical school instead.

12 Oct 2011

New robust technique holds promise for identifying trace mutant DNA sequences

Molecular DNA testing methods offer clinicians powerful tools that serve to confirm or identify disease diagnoses. High sensitivity and high specificity, however, are frequently a challenge to achieve with these methods. In a study scheduled for publication in the November issue of The Journal of Molecular Diagnostics, researchers describe a new, robust technique that holds promise for identifying trace mutant DNA sequences in an overwhelming population of unmutated DNA.

12 Oct 2011

Novel link between cell surface sugars, Darwinian sexual selection, and immune function

Researchers at the University of California, San Diego School of Medicine say that losing the ability to make a particular kind of sugar molecule boosted disease protection in early hominids, and may have directed the evolutionary emergence of our ancestors, the genus Homo.

11 Oct 2011

Receptor tyrosine kinases control PI3K signaling in human KRAS mutant colorectal cancers

Some cancers can be effectively treated with drugs inhibiting proteins known as receptor tyrosine kinases, but not those cancers caused by mutations in the KRAS gene. A team of researchers led by Jeffrey Engelman, at Massachusetts General Hospital Cancer Center, Boston, has now identified a potential way to effectively use receptor tyrosine kinases inhibitors to treat individuals with KRAS mutant colorectal cancers - combine them with inhibitors of the MEK/ERK signaling pathway.

11 Oct 2011

Rare and severe hypoglycemia could be genetic

The life-threatening condition depicts the fact that the body does not have enough energy to function. Scientists at the University of Cambridge say mutations in the AKT2 gene are to blame. Writing in the journal Science, they say there are already cancer drugs which target a similar process.

10 Oct 2011

Scientists identify 16M SNPs that associate with risk of gout, serum uric acid levels

Scientists at deCODE Genetics and academic collaborators from Iceland, Norway, Denmark, the Netherlands and the USA report the discovery of low frequency variants in the human genome that associate with risk of gout, a common inflammatory arthritis, and serum uric acid levels.

10 Oct 2011

Study identifies gene mutation responsible for higher frequency of Italian CDA II

Many of you might know that Congenital Dyserythropoietic Anemia type II (CDA II) is a rare blood disorder, due to a failure in final part of erythropoiesis. What will surprise you is the fact that some mutations responsible for the disease can be tracked 3.000 years back.

10 Oct 2011

Researchers identify gene responsible for aggressive, bold behavior in zebrafish

A gene responsible for aggressive and bold behavior has been identified in zebrafish by a team from CNRS/Laboratoire Neurobiologie et Développement.

7 Oct 2011

Strain echocardiography can help physicians detect early signs of cardiac toxicity in cancer patients

There is good news for cancer patients whose medical treatments put them at risk for future cardiac problems: using strain echocardiography can help physicians detect early signs of cardiac toxicity.

7 Oct 2011

Herceptin chemo combination could mean longer survival and lower side effects in breast cancer patients: Study

A new study released this Wednesday revealed that breast cancer that is highly aggressive but caught early could be best treated with a combination of Herceptin and chemotherapy.

6 Oct 2011

Researchers gain insight on how roundworm's brain operates as it moves

Using new optical equipment, a team of 11 researchers put roundworms into a world of virtual reality, monitored both their behavior and brain activity and gained unexpected information on how the organism's brain operates as it moves.

4 Oct 2011

Many average-risk women receive genetic testing for hereditary breast, ovarian cancers

Too many average-risk women and too few high-risk women receive genetic counseling and testing for hereditary breast and ovarian cancers, research shows. Experts at The University of Texas MD Anderson Cancer Center share advice to help patients and their doctors better evaluate family history and make more sound decisions about who should be tested.

4 Oct 2011

Three Penn labs receive NIH grant to speed translation of medical research into patient care

Three labs from the University of Pennsylvania have received $12.5 million from the National Institutes of Health (NIH) as part of its $143.8 million national grant program to challenge the scientific status quo with innovative ideas that have the potential to speed the translation of medical research into improved health for the American public.

4 Oct 2011

Complete Genomics, Scripps collaborate to unlock genetic secrets of lifelong health

Complete Genomics Inc., the whole human genome sequencing company, and the not-for-profit Scripps Health system today announced a major collaboration that will help further the Wellderly Study, a landmark scientific research initiative aimed at unlocking the genetic secrets of lifelong health.

4 Oct 2011

Researchers identify new enzyme function that may protect against anemia

Researchers at St. Michael's Hospital have discovered a new function for an enzyme that may protect against organ injury and death from anemia.

4 Oct 2011

Adaptimmune announces new board appointments as clinical programmes get underway

Adaptimmune, the T cell therapy company pioneering enhanced T cell receptor-driven T cells for the treatment of cancer and infectious disease, announces two new Board appointments with immediate effect. Dr Jonathan Knowles joins the Board as a non-executive director and Dr Helen Tayton-Martin, Adaptimmune’s Chief Operating Officer, becomes an executive director.

3 Oct 2011

New research uses Tilman model to study metastasis of prostate cells into bone

The invasion of a new species into an established ecosystem can be directly compared to the steps involved in cancer metastasis. New research published in BioMed Central's open access journal Theoretical Biology and Medical Modelling uses the Tilman model of competition between invasive species to study the metastasis of prostate cells into bone.

3 Oct 2011

Mutation News and Research

FDA grants Advaxis pre-IND meeting for ADXS-HER2 cancer immunotherapy

NCCN Oncology Research Program wins two GSK grants

Life Technologies launches Ion AmpliSeq Cancer Panel

ASHG to honor U of U geneticist with William Allan Award

New robust technique holds promise for identifying trace mutant DNA sequences

Novel link between cell surface sugars, Darwinian sexual selection, and immune function

Receptor tyrosine kinases control PI3K signaling in human KRAS mutant colorectal cancers

Rare and severe hypoglycemia could be genetic

Scientists identify 16M SNPs that associate with risk of gout, serum uric acid levels

Study identifies gene mutation responsible for higher frequency of Italian CDA II

Researchers identify gene responsible for aggressive, bold behavior in zebrafish

Strain echocardiography can help physicians detect early signs of cardiac toxicity in cancer patients

Herceptin chemo combination could mean longer survival and lower side effects in breast cancer patients: Study

Researchers gain insight on how roundworm's brain operates as it moves

Many average-risk women receive genetic testing for hereditary breast, ovarian cancers

Three Penn labs receive NIH grant to speed translation of medical research into patient care

Complete Genomics, Scripps collaborate to unlock genetic secrets of lifelong health

Researchers identify new enzyme function that may protect against anemia

Adaptimmune announces new board appointments as clinical programmes get underway

New research uses Tilman model to study metastasis of prostate cells into bone

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

Latest News