Genes News and Research

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Host-virus interaction drives adaptive mutation in bat CoV related to SARS-CoVs

Virus and receptor diversity is shaped by the need to evolve advanced weaponry to facilitate virus entry and infection, on the one hand, and host resistance, on the other. A new paper published on the preprint server bioRxiv* shows how this mechanism operates in a bat coronavirus, which is related to the earlier SARS coronavirus.

17 May 2020

Study shows human monoclonal antibodies can effectively neutralize SARS-CoV-2

US researchers have published a proof of concept on the efficacy of human monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in laboratory conditions, as well as their pioneering use in a mouse model. The study is available on the preprint server bioRxiv*.

17 May 2020

New algorithm could help investigate the genetic clues behind immunity

Scientists with UC San Diego's Jacobs School of Engineering and the Qualcomm Institute have developed a new gene prediction algorithm, called MINING-D, that could help researchers investigate the genetic clues behind the variation of symptoms shown in COVID-19 patients - information that is key to creating a versatile and effective vaccine.

15 May 2020

Genome-wide pattern found in glioblastoma tumors predicts patients' life expectancy

For the past 70 years, the best indicator of life expectancy for a patient with glioblastoma (GBM) -- the most common and the most aggressive brain cancer -- has simply been age at diagnosis.

15 May 2020

Study shows the combined effect of inherited and acquired mutations on cancer development

The common belief that tumors arise via activation of a few genes that "drive" cancer development is unsupported by a widespread investigation into those genes and others in three large patient genetic databases, according to a study led by Yale Cancer Center researchers.

15 May 2020

Mouse model helps track organism’s development from embryonic stage to adulthood

Scientists at the Stem Cell Research program at Boston Children's Hospital and Dana-Farber Cancer Institute/Harvard Medical School have devised a mouse model that lets researchers track every cell in the body, from the embryonic stage until adulthood.

15 May 2020

Activity of malaria-causing parasite is driven by the parasite's own inherent clocks

The activity of the parasite that causes malaria is driven by the parasite's own inherent clock, new research led by UT Southwestern scientists suggests. The findings, published this week in Science, could lead to new ways to fight this pervasive and deadly disease.

15 May 2020

Viral shedding seen in plasma donors who have recovered from COVID-19

Researchers from the University of Wisconsin-Madison have found that plasma donors who have recovered from the deadly COVID-19 infection were still shedding viral RNA. This could be significant they write in their article titled, “Prolonged viral RNA shedding after COVID-19 symptom resolution in older convalescent plasma donors,” that is published on the preprint server Medrxiv* prior to peer review.

15 May 2020

Malaria's characteristic cycle of fever and chills is a result of parasite's own influence

Scientists from the Walter Reed Army Institute of Research joined partners at Duke University, Florida Atlantic University and Montana State University to publish a study providing clear evidence that malaria's characteristic cycle of fever and chills is a result of the parasite's own influence--not factors from the host.

15 May 2020

First detailed study of the epigenetic landscape of human tumor organoids

The researcher Manel Esteller performs the first massive epigenetic characterization in organoids or 3D cancer cultures and makes the data available to the research community to facilitate new findings on tumor development and progression.

15 May 2020

Genome-based monitoring of multi-resistant pathogen can help improve infection control

S. maltophilia strains occur in several natural and human associated ecosystems. The bacterium was long regarded as relatively unproblematic but is now considered to be one of the most feared hospital pathogens, as it frequently causes infections and is resistant to a number of antibiotics.

15 May 2020

Reductive stress is intolerable, can induce heart failure

Many heart diseases are linked to oxidative stress, an overabundance of reactive oxygen species. The body reacts to reduce oxidative stress -- where the redox teeter-totter has gone too far up -- through production of endogenous antioxidants that reduce the reactive oxygen species.

14 May 2020

Researchers identify new breast cancer gene in young women

Over the past 20 years, our knowledge of hereditary diseases has taken a quantum leap, and several hereditary gene variants have been found that may predispose to the development of cancer.

14 May 2020

Researchers identify a group of dysregulated genes in autism

Autism has long been associated only with behavioral and environmental factors, but the role of genetics in its development is now increasingly evident. Some 100 genes have been found to play a role in autism spectrum disorder, and another thousand are being studied to the same end.

14 May 2020

Study provides new insights on mechanisms that promote cancer

Like subway com muters on a crowded train, cells generally prefer not to be packed in too tightly. In fact, they have set up mechanisms to avoid this, a phenomenon called "contact inhibition." A hallmark of cancer cells is that they lack this contact inhibition, and instead become pushy, facilitating their spread.

14 May 2020

Variations in genome’s 'dark matter' region can make patients susceptible to inflammatory diseases

A study led by researchers at the Babraham Institute in collaboration with the Wellcome Sanger Institute has uncovered how variations in a non-protein coding 'dark matter' region of the genome could make patients susceptible to complex autoimmune and allergic diseases such as inflammatory bowel disease.

14 May 2020

Study: Neurons expressing dopamine D2 receptors have different molecular features, functions

An international collaboration, which included the involvement of the research team from the Institut de Neurociències of the UAB (INC-UAB), has shown that neurons expressing dopamine D2 receptors have different molecular features and functions, depending on their anatomical localization within the striatum.

14 May 2020

A deep look into hormone-producing cells of the gut

Researchers from the Hubrecht Institute and Utrecht University generated an in-depth description of the human hormone-producing cells of the gut, in a large collaborative effort with other research teams. The results are presented in the scientific journal Cell on the 13th of May.

13 May 2020

U of A researchers and Tonix Pharmaceuticals join forces to develop, test COVID-19 vaccine

University of Alberta researchers launched a joint effort with U.S.-based Tonix Pharmaceuticals to develop and test a vaccine against COVID-19.

13 May 2020

First detailed study of the epigenetic landscape of human tumor organoids

Frequently, promising cancer therapies fail when applied to patients in the real clinical setting. This occurs despite many of these new treatments demonstrating promising results at the preclinical stage in the lab.

13 May 2020

Genes News and Research

Host-virus interaction drives adaptive mutation in bat CoV related to SARS-CoVs

Study shows human monoclonal antibodies can effectively neutralize SARS-CoV-2

New algorithm could help investigate the genetic clues behind immunity

Genome-wide pattern found in glioblastoma tumors predicts patients' life expectancy

Study shows the combined effect of inherited and acquired mutations on cancer development

Mouse model helps track organism’s development from embryonic stage to adulthood

Activity of malaria-causing parasite is driven by the parasite's own inherent clocks

Viral shedding seen in plasma donors who have recovered from COVID-19

Malaria's characteristic cycle of fever and chills is a result of parasite's own influence

First detailed study of the epigenetic landscape of human tumor organoids

Genome-based monitoring of multi-resistant pathogen can help improve infection control

Reductive stress is intolerable, can induce heart failure

Researchers identify new breast cancer gene in young women

Researchers identify a group of dysregulated genes in autism

Study provides new insights on mechanisms that promote cancer

Variations in genome’s 'dark matter' region can make patients susceptible to inflammatory diseases

Study: Neurons expressing dopamine D2 receptors have different molecular features, functions

A deep look into hormone-producing cells of the gut

U of A researchers and Tonix Pharmaceuticals join forces to develop, test COVID-19 vaccine

First detailed study of the epigenetic landscape of human tumor organoids

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