Genome-based monitoring of multi-resistant pathogen can help improve infection control

S. maltophilia strains occur in several natural and human associated ecosystems. The bacterium was long regarded as relatively unproblematic but is now considered to be one of the most feared hospital pathogens, as it frequently causes infections and is resistant to a number of antibiotics.

This can be particularly dangerous for immune-compromised patients or for patients with underlying inflammatory lung diseases such as cystic fibrosis. Although almost any organ can be affected, infections of the respiratory tract, bacteraemia or catheter-related infections of the bloodstream are the most common.

In view of the increasing importance of this pathogen and the often-severe clinical consequences of an infection, knowledge about the virulence factors and about the local and global transmission of S. maltophilia bacteria is urgently needed.

Scientists from a total of eight countries initially established a genotyping method that enables the standardized analysis of the different genomes of S. maltophilia strains.

The DZIF teams around Prof. Stefan Niemann (FZB), Prof. Jan Rupp, (Clinic of Infectiology and Microbiology, Campus Lübeck) and Prof. Ulrich Nübel from the Leibniz Institute DSMZ (German Collection of Microorganisms and Cell Cultures GmbH ) in Braunschweig were involved.

The scientists found that the S. maltophilia complex can be divided into a total of 23 lineages with different prevalence levels. One particular line of descent appeared worldwide and had the highest rate of human-associated strains.

This "Sm6" strain was also characterized by the presence of key virulence genes and resistance genes.

This suggests that a specific gene configuration may promote the spread of different S. maltophilia subtypes in the hospital setting, i.e. under antimicrobial treatment."

Matthias Gröschel, Study Lead Author

Transmission analysis also identified several potential outbreak events of genetically closely related strains that were isolated within days or weeks in the same hospitals.

"Combined with studies on other pathogens, our results show how systematic genome-based monitoring of S. maltophilia and other pathogens in hospital settings can help detect transmission pathways and improve infection control," Thomas Kohl, senior author of the study at FZ Borstel, adds.

Source:
Journal reference:

Gröschel, M. I. The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia. Nature Communications. doi.org/10.1038/s41467-020-15123-0.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
You might also like... ×
Faulty immune response to SARS-CoV-2 one of the main causes of death