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Discovering a new gene in monkeys that could help to develop new antivirals

We spoke to Dr. Nels Elde about his latest research that led to the discovery of a new gene in monkeys that could help to develop new antivirals.

26 Nov 2021

Immune response to influenza virus influenced by genetic ancestry

New research at the University of Chicago has found differences in immune pathway activation to influenza infection between individuals of European and African genetic ancestry.

25 Nov 2021

New mechanism involved in early melanoma metastasis discovered

How tumors manipulate their environment to advance is one of the big questions that Peinado has been trying to answer for years.

25 Nov 2021

Combination of two targeted drugs shows "clinically meaningful" activity in some malignant brain tumors

A combination of two targeted cancer drugs showed unprecedented, "clinically meaningful" activity in patients with highly malignant brain tumors that carried a rare genetic mutation, according to a clinical trial report by investigators from Dana-Farber Cancer Institute.

25 Nov 2021

International collaboration secures €1M grant to investigate new treatment target for lymphoma

An international collaboration involving researchers from Queen Mary University of London, Memorial Sloan Kettering Cancer Center, New York and Dana-Farber Cancer Institute, Boston has secured a €1M research grant from Dutch blood cancer charity, Lymph&Co, to investigate a new treatment target for lymphoma.

25 Nov 2021

Mtb's exotoxin secretion and trafficking mechanism revealed

Six years ago, Michael Niederweis, Ph.D., described the first known toxin of the deadly pathogen Mycobacterium tuberculosis (Mtb), an exotoxin that had gone undetected for 132 years.

25 Nov 2021

What may the future hold in terms of SARS-CoV-2 variants?

Researchers fit data on SARS-CoV-2 variants by exploiting a function that depends on the global number of infected cases since the start of the pandemic.

25 Nov 2021

MIT scientists discover how molecular clusters interact with chromosomes in the nucleus

A cell stores all of its genetic material in its nucleus, in the form of chromosomes, but that's not all that's tucked away in there. The nucleus is also home to small bodies called nucleoli - clusters of proteins and RNA that help build ribosomes.

25 Nov 2021

Scientists link increased air pollution to an uptick in cases of lung cancer

An international team of scientists, led by Nanyang Technological University, Singapore (NTU Singapore), has linked increased air pollution to an uptick in cases of lung adenocarcinoma (LADC) worldwide.

25 Nov 2021

Breakthrough infections from SARS-CoV-2 Delta variant among vaccinated healthcare workers

A new study published on the medRxiv* preprint server employed in-silico techniques, combining genomic and epidemiological data, to determine possible Delta-variant transmission events between vaccinated healthcare workers (HCWs) in Indian hospitals.

25 Nov 2021

Impeding SARS‑CoV‑2 evolution by targeting low-probability stochastic events

Researchers explore the emergence of more fit SARS-CoV-2 variants using a stochastic evolutionary modeling framework during long-term infections.

24 Nov 2021

Treatment with antihistamines associated with improved responses to immunotherapy

New research from The University of Texas MD Anderson Cancer Center found that treatment with antihistamines, a commonly used allergy medication, was associated with improved responses to immune checkpoint inhibitors.

24 Nov 2021

Study uncovers important genetic predispositions for acute myeloid leukemia

The National Center for Tumor Diseases Dresden is a joint institution of the German Cancer Research Center, the University Hospital Carl Gustav Carus Dresden, Carl Gustav Carus Faculty of Medicine at TU Dresden and the Helmholtz-Zentrum Dresden-Rossendorf.

24 Nov 2021

An assessment of potential epitopes in SARS-CoV-2 structural proteins

Researchers utilized multiple bioinformatics resources to identify potent T- and B-cell epitopes of four SARS-CoV-2 structural proteins.

24 Nov 2021

Finding potential biomarkers to predict response to immunotherapy in nonhypermutated cancers

Scientists have discovered a potential biomarker that could more accurately identify which patients with non-hypermutated cancers will respond to specialized immunotherapy drugs called immune checkpoint inhibitors, according to findings published in Science Translational Medicine.

24 Nov 2021

Experimental compound reduces diabetic complications in mice

An experimental compound reduced complications of type 1 and type 2 diabetes in mice—not by lowering blood sugar—but by countering its consequences of cell death, inflammation, and organ damage.

24 Nov 2021

Bat coronavirus ecology, evolution, and spillover

In a review published in Nature Reviews Microbiology, the authors collate information about the ecology and evolution of bat coronaviruses.

24 Nov 2021

Spread and evolution of SARS-CoV-2 lineages with possible recombination events

Researchers examined the dissemination and evolution of four SARS-CoV-2 lineages as well as the potential that one or more recombination events played a role in their evolution.

24 Nov 2021

Study explains why moles can change into melanoma

Moles and melanomas are both skin tumors that come from the same cell called melanocytes. The difference is that moles are usually harmless, while melanomas are cancerous and often deadly without treatment.

23 Nov 2021

Novel protein regulator of tumor angiogenesis may be a therapeutic target for difficult-to-treat cancers

A novel protein regulator of tumor angiogenesis, TMEM230, was recently characterized by researchers to have a role in tumor development and vascularization, with potential as a target for anti-tumor therapy in difficult-to-treat cancers such as glioblastoma.

23 Nov 2021