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Researchers describe key cellular receptor involved in ovarian cancer metastasis

Researchers of the Molecular Signaling in Cancer group of the Oncobell program - proCURE Program have described a key cellular receptor in the processes of metastasis in ovarian cancer.

4 Jan 2018

Study reveals a loophole in treatment of chronic lymphocytic leukemia

A team of researchers in Italy and Austria has determined that a drug approved to treat chronic lymphocytic leukemia (CLL) may be less effective in a particular subset of patients.

4 Jan 2018

Newly solved glucagon receptor structure provides most accurate template for drug design

Class B G protein-coupled receptors (GPCRs) exert essential action in hormonal homeostasis and are important therapeutic targets for a variety of diseases including metabolic disorders such as type 2 diabetes.

4 Jan 2018

'Thunder' protein activity may be associated with behavioral disorders like schizophrenia

Researchers at Johns Hopkins Medicine report they have identified rare genetic variations in a protein called Thorase, which is responsible for breaking down receptors at the connections between neurons in the brain.

3 Jan 2018

Researchers discover novel genes responsible for Alzheimer's disease

Researchers have identified several new genes responsible for Alzheimer's disease (AD) including those leading to functional and structural changes in the brain and elevated levels of AD proteins in cerebrospinal fluid (CSF).

3 Jan 2018

Experimental diabetes drugs can make cancer cells vulnerable to chemotherapy agents

Scientists at Dana-Farber Cancer Institute have shown that experimental diabetes drugs can make cancer cells more vulnerable to traditional chemotherapy agents, and they say such combinations should be explored to potentially improve outcomes for cancer patients.

2 Jan 2018

Arterial stiffness improves with high doses of vitamin D supplementation, study finds

In just four months, high-doses of vitamin D reduce arterial stiffness in young, overweight/obese, vitamin-deficient, but otherwise still healthy African-Americans, researchers say.

2 Jan 2018

Diabetes drug holds promise of being developed into new treatment for Alzheimer's

A drug developed for diabetes could be used to treat Alzheimer's after scientists found it "significantly reversed memory loss" in mice through a triple method of action.

2 Jan 2018

Gene therapy with CAR T-cells could create long-term immunity from HIV

Through gene therapy, researchers engineered blood-forming stem cells (hematopoietic stem/progenitor cells, or HSPCs) to carry chimeric antigen receptor (CAR) genes to make cells that can detect and destroy HIV-infected cells.

29 Dec 2017

Discovery of key protein’s structure may help improve drug design

Scientists at The Scripps Research Institute have peered deep into the heart of a key protein used in drug design and discovered dynamic structural features that may lead to new ways to target diseases.

29 Dec 2017

UCLA study reveals positive effects of estrogen treatment in people with MS

A study by UCLA researchers reveals the cellular basis for how the hormone estrogen protects against damage to the central nervous system in people with multiple sclerosis (MS).

28 Dec 2017

Innovative skin patch to reduce bulging tummy fats could help address obesity problem

It combines a new way to deliver drugs, via a micro-needle patch, with drugs that are known to turn energy-storing white fat into energy-burning brown fat.

28 Dec 2017

Nanobiotix receives FDA approval for first immuno-oncology trial

NANOBIOTIX, a late clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, today announced the U.S. Food and Drug Administration has approved its Investigational New Drug Application for NBTXR3, a first-in-class nanoparticle designed for direct injection into cancerous tumors, activated by stereotactic ablative radiotherapy (SABR) and administered in combination with an anti-PD1 antibody (nivolumab or pembrolizumab).

26 Dec 2017

Study finds role of ligands in allergic sensitization phase

Researchers from Universidad Politécnica de Madrid find direct evidence that the ligands, compounds carried by allergens, are actively involved in the allergic sensitization phase.

26 Dec 2017

New method sifts through millions of molecular targets to find precise tumor beacon

By screening millions of molecular targets, researchers have uncovered a tumor beacon detected by the immune cells of two patients with colorectal cancer.

22 Dec 2017

Hormone therapy combination may improve metabolism without increasing risk of reproductive cancer

Treating ovariectomized mice with a combination of conjugated estrogens and the drug bazedoxifene triggers the expression of genes that improve metabolism and prevent weight gain - without stimulating the uterus and increasing risks of reproductive cancer, a new study suggests.

22 Dec 2017

Study suggests new target to treat prostate cancer

Hokkaido University researchers have uncovered a cellular protein that stabilizes a tumor promoting signaling pathway, suggesting a new target to treat prostate cancer.

22 Dec 2017

Ability to defend against environmental stress may affect longevity

A shorter life may be the price an organism pays for coping with the natural assaults of daily living, according to researchers at the National Institutes of Health and their colleagues in Japan.

21 Dec 2017

Researchers discover gene that influences how sleep-deprived people perform mental tasks

Washington State University researchers have discovered a genetic variation that predicts how well people perform certain mental tasks when they are sleep deprived.

21 Dec 2017

Findings provide better understanding of thyroid hormones' role in mammalian seasonal changes

Researchers now have a better understanding of the role that thyroid hormones, the tissues that produce them, and the biochemical pathways on which they act have in driving seasonal reproduction in some mammals, and how this new information may help explain seasonal changes in metabolism and mood that affect humans.

21 Dec 2017

Receptor News and Research

Researchers describe key cellular receptor involved in ovarian cancer metastasis

Study reveals a loophole in treatment of chronic lymphocytic leukemia

Newly solved glucagon receptor structure provides most accurate template for drug design

'Thunder' protein activity may be associated with behavioral disorders like schizophrenia

Researchers discover novel genes responsible for Alzheimer's disease

Experimental diabetes drugs can make cancer cells vulnerable to chemotherapy agents

Arterial stiffness improves with high doses of vitamin D supplementation, study finds

Diabetes drug holds promise of being developed into new treatment for Alzheimer's

Gene therapy with CAR T-cells could create long-term immunity from HIV

Discovery of key protein’s structure may help improve drug design

UCLA study reveals positive effects of estrogen treatment in people with MS

Innovative skin patch to reduce bulging tummy fats could help address obesity problem

Nanobiotix receives FDA approval for first immuno-oncology trial

Study finds role of ligands in allergic sensitization phase

New method sifts through millions of molecular targets to find precise tumor beacon

Hormone therapy combination may improve metabolism without increasing risk of reproductive cancer

Study suggests new target to treat prostate cancer

Ability to defend against environmental stress may affect longevity

Researchers discover gene that influences how sleep-deprived people perform mental tasks

Findings provide better understanding of thyroid hormones' role in mammalian seasonal changes

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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